Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Taylor S. Mills"'
Autor:
James S. Chavez, Jennifer L. Rabe, Katia E. Niño, Harrison H. Wells, Rachel L. Gessner, Taylor S. Mills, Giovanny Hernandez, Eric M. Pietras
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Chronic inflammation is a common feature of aging and numerous diseases such as diabetes, obesity, and autoimmune syndromes and has been linked to the development of hematological malignancy. Blood-forming hematopoietic stem cells (HSC) can contribut
Externí odkaz:
https://doaj.org/article/95336b6d9bfa4ee79efcfe80a9a8020f
Autor:
Alberto Dinarello, Taylor S. Mills, Isak W. Tengesdal, Nicholas E. Powers, Tania Azam, Charles A. Dinarello
Publikováno v:
Cells, Vol 12, Iss 2, p 294 (2023)
The NLRP3 inflammasome is a multimolecular complex that processes inactive IL-1β and IL-18 into proinflammatory cytokines. OLT1177 is an orally active small compound that specifically inhibits NLRP3. Here, B16F10 melanoma were implanted in mice and
Externí odkaz:
https://doaj.org/article/abd15eeebeaa438fbc479ff0c62ae5a3
Autor:
Giulio Cavalli, Isak W. Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez-Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor S. Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A.B. Joosten, Mihai G. Netea, Charles A. Dinarello
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108955- (2021)
Summary: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histon
Externí odkaz:
https://doaj.org/article/090779f385b2426584b8720869662ba6
Autor:
James S. Chavez, Jennifer L. Rabe, Giovanny Hernandez, Taylor S. Mills, Katia E. Niño, Pavel Davizon-Castillo, Eric M. Pietras
Publikováno v:
Cells, Vol 11, Iss 4, p 680 (2022)
The transcription factor PU.1 is a critical regulator of lineage fate in blood-forming hematopoietic stem cells (HSC). In response to pro-inflammatory signals, such as the cytokine IL-1β, PU.1 expression is increased in HSC and is associated with my
Externí odkaz:
https://doaj.org/article/b3e5fe7c3d834606a607973c9699bafb
Autor:
Giovanny Hernandez, Taylor S. Mills, Jennifer L. Rabe, James S. Chavez, Susan Kuldanek, Gregory Kirkpatrick, Leila Noetzli, Widian K. Jubair, Michelle Zanche, Jason R. Myers, Brett M. Stevens, Courtney J. Fleenor, Biniam Adane, Charles A. Dinarello, John Ashton, Craig T. Jordan, Jorge Di Paola, James R. Hagman, V. Michael Holers, Kristine A. Kuhn, Eric M. Pietras
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also characterized by aberrant blood phenotypes including anemia and suppressed lymphopoiesis that
Externí odkaz:
https://doaj.org/article/eca59744a0444860b5057f8bf06972fb
Autor:
Taylor S Mills, Tatiana Eliseeva, Stephanie M Bersie, Grace Randazzo, Jhenya Nahreini, Ko Uoon Park, Joseph A Brzezinski
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0176905 (2017)
The mouse retina comprises seven major cell types that exist in differing proportions. They are generated from multipotent progenitors in a stochastic manner, such that the relative frequency of any given type generated changes over time. The mechani
Externí odkaz:
https://doaj.org/article/2d62ab9324ca4622a34e3484f4a7d17d
Autor:
Pavel Davizon-Castillo, Eric M. Pietras, Taylor S. Mills, Jennifer L. Rabe, Katia E. Niño, Giovanny Hernandez, James S. Chavez
The transcription factor PU.1 is a critical regulator of lineage fate in blood-forming hematopoietic stem cells (HSC). In response to inflammatory signals, PU.1 expression is increased in HSC, activating myeloid differentiation genes while repressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4acd997f6bffc0de5a3ed53c88c39f5e
https://doi.org/10.1101/2021.10.25.465758
https://doi.org/10.1101/2021.10.25.465758
Autor:
Jason R. Myers, Eric M. Pietras, Rachel L Gessner, Katia E. Niño, James DeGregori, Nouraiz Ahmed, Pavel Davizon-Castillo, James S. Chavez, Hyunmin Kim, Taylor S. Mills, Zhonghe Ke, Robert S. Welner, Brett M. Stevens, Timm Schroeder, Beau M Idler, Dirk Loeffler, Giovanny Hernandez, Kelly C. Higa, John M. Ashton, Craig T. Jordan, Hideaki Nakajima, Jennifer L. Rabe
Publikováno v:
Journal of Experimental Medicine, 218 (6)
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Hematopoietic stem cells (HSCs) are capable of entering the cell cycle to replenish the blood system in response to inflammatory cues; however, excessive proliferation in response to chronic inflammation can lead to either HSC attrition or expansion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c5f0deeced3592614adf5e265ef87c
https://hdl.handle.net/20.500.11850/480362
https://hdl.handle.net/20.500.11850/480362
Autor:
Carlo Marchetti, Charles A. Dinarello, Douglas G. Osborne, Charles Preston Neff, Beat Vögeli, Morkos A. Henen, Nicholas E. Powers, Adolfo G Mauro, Eric M. Pietras, Angelo D'Alessandro, Fabia Gamboni, Leo A. B. Joosten, Brent E. Palmer, Tania Azam, Mayumi Fujita, Taylor S. Mills, Dennis M. de Graaf, Davide Stefanoni, Dinoop Ravindran Menon, James DeGregori, Isak W. Tengesdal, Aik Choon Tan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences USA, 118
Proceedings of the National Academy of Sciences USA, 118, 10
Proceedings of the National Academy of Sciences USA, 118
Proceedings of the National Academy of Sciences USA, 118, 10
Significance The nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 (NLRP3) inflammasome, an intracellular complex that regulates maturation and release of interleukin (IL)-1β, is active in biopsies of metastatic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ce371aacf6f09b53e1fd04dd31ce69
https://doi.org/10.1073/pnas.2000915118
https://doi.org/10.1073/pnas.2000915118
Autor:
Davide Stefanoni, Silvia Giugliano, Eleonora Cantoni, Giulio Cavalli, Elan Z. Eisenmensser, Isak W. Tengesdal, Kiki Schraa, Lorenzo Dagna, Mihai G. Netea, Laura Cassina, Angelo D'Alessandro, Travis Nemkov, Leo A. B. Joosten, Eric M. Pietras, Jorge Domínguez-Andrés, Mark S. Gresnigt, Rob J.W. Arts, Taylor S. Mills, Raffaella Molteni, Alessandra Boletta, Charles A. Dinarello
Publikováno v:
Cell Reports, 35, 1
Cell Reports, 35
Cell Reports, Vol 35, Iss 1, Pp 108955-(2021)
Cell Reports
Cell Reports, 35
Cell Reports, Vol 35, Iss 1, Pp 108955-(2021)
Cell Reports
Summary Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821f395481082ca79f147c5d9ab4a39d