Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Taylor R. Nicholas"'
Autor:
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Siegen A. McKellar, Taylor R. Nicholas, Toshihiro Banjo, Edie I. Crosse, Robert K. Bradley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Alternative polyadenylation (APA) is strikingly dysregulated in many cancers. Although global APA dysregulation is frequently associated with poor prognosis, the importance of most individual APA events is controversial simply because few ha
Externí odkaz:
https://doaj.org/article/38f1b82c8b184f27a198e5de36ed4995
Autor:
Taylor R. Nicholas, Jingwei Meng, Benjamin M. Greulich, Teresa Stevie Morris, Peter C. Hollenhorst, Irina U. Agoulnik
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Aberrant expression of the transcription factor ERG is a key driving event in approximately one-half of all of prostate cancers. Lacking an enzymatic pocket and mainly disordered, the structure of ERG is difficult to exploit for therapeutic design. W
Externí odkaz:
https://doaj.org/article/146c60cf558e4120a356be6f78bdb5ab
Autor:
Vivekananda Kedage, Nagarathinam Selvaraj, Taylor R. Nicholas, Justin A. Budka, Joshua P. Plotnik, Travis J. Jerde, Peter C. Hollenhorst
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1289-1301 (2016)
Summary: More than 50% of prostate tumors have a chromosomal rearrangement resulting in aberrant expression of an oncogenic ETS family transcription factor. However, mechanisms that differentiate the function of oncogenic ETS factors expressed in pro
Externí odkaz:
https://doaj.org/article/875f7987522647da9e3288a80e15b123
Publikováno v:
NAR Cancer
Ewing sarcoma breakpoint region 1 (EWSR1) encodes a multifunctional protein that can cooperate with the transcription factor ERG to promote prostate cancer. The EWSR1 gene is also commonly involved in oncogenic gene rearrangements in Ewing sarcoma. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c7a86fa23c454a162f293c05fc4817
http://europepmc.org/articles/PMC8364332
http://europepmc.org/articles/PMC8364332
SummaryEwing sarcoma breakpoint region 1 (EWSR1) encodes a multifunctional protein that can cooperate with the transcription factor ERG to promote prostate cancer. The EWSR1 gene is also commonly involved in oncogenic gene rearrangements in Ewing sar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13940743aac2bbe64d2b9292e899aaff
https://doi.org/10.1101/2020.03.25.008391
https://doi.org/10.1101/2020.03.25.008391
Publikováno v:
Advances in experimental medicine and biology. 1210
Prostate cancer is unique among carcinomas in that a fusion gene created by a chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG rearrangement drives aberrant expression of the ETS family transcription factor ERG in 50% of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5280e35a54ea297f599eb54a5fb74321
https://pubmed.ncbi.nlm.nih.gov/31900919
https://pubmed.ncbi.nlm.nih.gov/31900919
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030326555
Prostate cancer is unique among carcinomas in that a fusion gene created by a chromosomal rearrangement is a common driver of the disease. The TMPRSS2/ERG rearrangement drives aberrant expression of the ETS family transcription factor ERG in 50% of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4905ee2fd2f65f73a1125ec79f7cf55
https://doi.org/10.1007/978-3-030-32656-2_18
https://doi.org/10.1007/978-3-030-32656-2_18
Autor:
Nagarathinam Selvaraj, Vivekananda Kedage, Justin A. Budka, Taylor R. Nicholas, Joshua P. Plotnik, Travis J. Jerde, Peter C. Hollenhorst
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1289-1301 (2016)
Summary: More than 50% of prostate tumors have a chromosomal rearrangement resulting in aberrant expression of an oncogenic ETS family transcription factor. However, mechanisms that differentiate the function of oncogenic ETS factors expressed in pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156b9932ab77ef5e20e454c0074bcaeb
https://doi.org/10.1016/j.celrep.2016.10.001
https://doi.org/10.1016/j.celrep.2016.10.001
Autor:
Peter C. Hollenhorst, Vivekananda Kedage, Brady G. Strittmatter, Taylor R. Nicholas, Travis J. Jerde, Nagarathinam Selvaraj, Justin A. Budka
Publikováno v:
Cancer Research. 78:A023-A023
More than one-half of prostate tumors have a chromosomal rearrangement that results in the overexpression of an oncogenic ETS family transcription factor. The most common fusion, TMPRSS2/ERG, results in expression of ERG, a protein that is not normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::901fb9fe8813bec80bd420a1b0569feb
https://doi.org/10.1158/1538-7445.prca2017-a023
https://doi.org/10.1158/1538-7445.prca2017-a023