Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Taylor R Cushman"'
Autor:
Hari Menon, Dawei Chen, Rishab Ramapriyan, Maria Angelica Cortez, Hampartsoum B Barsoumian, Ahmed I Younes, Quynh-Nhu Nguyen, Nathan I Comeaux, Mauricio S Caetano, Taylor R Cushman, Jonathan E Schoenhals, Timothy P Reilly, Fatemeh Masrorpour, Ailin Li, Stephen G Chun
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Despite some successes with checkpoint inhibitors for treating cancer, most patients remain refractory to treatment, possibly due to the inhibitory nature of the tumor stroma that impedes the function and entry of effector cells. We devise
Externí odkaz:
https://doaj.org/article/a6974833715940429eb0dcc8b93bbb3f
Autor:
Hari Menon, Dawei Chen, Rishab Ramapriyan, Vivek Verma, Hampartsoum B. Barsoumian, Taylor R. Cushman, Ahmed I. Younes, Maria A. Cortez, Jeremy J. Erasmus, Patricia de Groot, Brett W. Carter, David S. Hong, Isabella C. Glitza, Renata Ferrarotto, Mehmet Altan, Adi Diab, Stephen G. Chun, John V. Heymach, Chad Tang, Quynh N. Nguyen, James W. Welsh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019)
Abstract Background Preclinical evidence suggests that low-dose radiation may overcome the inhibitory effects of the tumor stroma and improve a tumor’s response to immunotherapy, when combined with high-dose radiation to another tumor. The aim of t
Externí odkaz:
https://doaj.org/article/981dd3b90cab4db297a9281eb4151cb1
Publikováno v:
Advances in Radiation Oncology, Vol 3, Iss 4, Pp 506-511 (2018)
Purpose: Although immunotherapy is a rapidly emerging modality for cancer care, there have been multiple reports of fatal toxicities. There have also been cases of treatment-related deaths with combined non-immunotherapeutic biologic compounds with r
Externí odkaz:
https://doaj.org/article/87d33d4553a64736a6236e0033a196ab
Autor:
Hari Menon, Rishab Ramapriyan, Taylor R. Cushman, Vivek Verma, Hans H. Kim, Jonathan E. Schoenhals, Cemre Atalar, Ugur Selek, Stephen G. Chun, Joe Y. Chang, Hampartsoum B. Barsoumian, Quynh-Nhu Nguyen, Mehmet Altan, Maria A. Cortez, Stephen M. Hahn, James W. Welsh
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
In recent decades, there has been substantial growth in our understanding of the immune system and its role in tumor growth and overall survival. A central finding has been the cross-talk between tumor cells and the surrounding environment or stroma.
Externí odkaz:
https://doaj.org/article/6fd0a56ff7ea49729ffe0f89fbcc8886
Autor:
David S. Hong, Ritsuko Komaki, Stephen Hahn, Daniel R. Gomez, Clark Anderson, Kelvin Wang, Maria E. Cabanillas, Ramona Dadu, Sherif G. Shaaban, Uma Raju, Vivek Verma, Adi Diab, James P. Allison, Padmanee Sharma, Quynh Nguyen, Erminia Massarelli, Maria Angelica Cortez, Hari Menon, Hampartsoum B. Barsoumian, Rishab Ramapriyan, George R. Simon, Joe Y. Chang, Vivek Subbiah, Taylor R. Cushman, Vassiliki A. Papadimitrakopoulou, John V. Heymach, Kenneth R. Hess, Aung Naing, Patricia de Groot, Chad Tang, James W. Welsh
Supplementary Figure S1. CONSORT flow diagram for patient selection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f72a991e3621a846e33408375d809be
https://doi.org/10.1158/2326-6066.22542834
https://doi.org/10.1158/2326-6066.22542834
Autor:
David S. Hong, Ritsuko Komaki, Stephen Hahn, Daniel R. Gomez, Clark Anderson, Kelvin Wang, Maria E. Cabanillas, Ramona Dadu, Sherif G. Shaaban, Uma Raju, Vivek Verma, Adi Diab, James P. Allison, Padmanee Sharma, Quynh Nguyen, Erminia Massarelli, Maria Angelica Cortez, Hari Menon, Hampartsoum B. Barsoumian, Rishab Ramapriyan, George R. Simon, Joe Y. Chang, Vivek Subbiah, Taylor R. Cushman, Vassiliki A. Papadimitrakopoulou, John V. Heymach, Kenneth R. Hess, Aung Naing, Patricia de Groot, Chad Tang, James W. Welsh
Patient characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df75acf44fcc9316a609c9fe858423b
https://doi.org/10.1158/2326-6066.22542831.v1
https://doi.org/10.1158/2326-6066.22542831.v1
Autor:
David S. Hong, Ritsuko Komaki, Stephen Hahn, Daniel R. Gomez, Clark Anderson, Kelvin Wang, Maria E. Cabanillas, Ramona Dadu, Sherif G. Shaaban, Uma Raju, Vivek Verma, Adi Diab, James P. Allison, Padmanee Sharma, Quynh Nguyen, Erminia Massarelli, Maria Angelica Cortez, Hari Menon, Hampartsoum B. Barsoumian, Rishab Ramapriyan, George R. Simon, Joe Y. Chang, Vivek Subbiah, Taylor R. Cushman, Vassiliki A. Papadimitrakopoulou, John V. Heymach, Kenneth R. Hess, Aung Naing, Patricia de Groot, Chad Tang, James W. Welsh
Ipilimumab is effective for patients with melanoma, but not for those with less immunogenic tumors. We report a phase II trial of ipilimumab with concurrent or sequential stereotactic ablative radiotherapy to metastatic lesions in the liver or lung (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb57f416f97b220707b2187174809e3
https://doi.org/10.1158/2326-6066.c.6550050.v1
https://doi.org/10.1158/2326-6066.c.6550050.v1
Autor:
James W. Welsh, Maria Angelica Cortez, Patrick Hwu, John V. Heymach, Adi Diab, Daniel R. Gomez, Quynh N. Nguyen, Joe Y. Chang, Taylor R. Cushman, Alexandra Cadena, Ahmed I. Younes, Ailin Li, Mauricio S. Caetano, Niranjan Yanamandra, Heather L. Jackson, Jonathan E. Schoenhals, Hampartsoum B. Barsoumian, Sharareh Niknam
Purpose: Radiation is used extensively to treat localized cancer, but improved understanding of its effects on the immune system has increased interest in its potential systemic (abscopal) effects, particularly in combination with checkpoint inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e2d4a46daee3e5098ca546aae756b7
https://doi.org/10.1158/1078-0432.c.6527274
https://doi.org/10.1158/1078-0432.c.6527274
Autor:
James W. Welsh, Maria Angelica Cortez, Quynh-Nhu Nguyen, Ailin Li, Jonathan E. Schoenhals, Taylor R. Cushman, Alexandra P. Cadena, Timothy P. Reilly, Thomas Spires, Chan Gao, Hari Menon, Michael Quigley, Hampartsoum B. Barsoumian, Ahmed I. Younes, Mauricio S. Caetano
CD8+ CD103+ TRM cells express high levels of PD1. Flow cytometric analysis for TILs on day 29 from the triple therapy group (RT + α-PD1 + α-MerTK). Cells were gated on CD45 population then on CD4 and CD8, followed by CD8 and CD103 to check for PD1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469c4c8c8de32c487bd3edd568a855f7
https://doi.org/10.1158/1078-0432.22472610
https://doi.org/10.1158/1078-0432.22472610
Autor:
James W. Welsh, Maria Angelica Cortez, Quynh-Nhu Nguyen, Ailin Li, Jonathan E. Schoenhals, Taylor R. Cushman, Alexandra P. Cadena, Timothy P. Reilly, Thomas Spires, Chan Gao, Hari Menon, Michael Quigley, Hampartsoum B. Barsoumian, Ahmed I. Younes, Mauricio S. Caetano
Purpose:Radiotherapy (RT) traditionally has been used for local tumor control in the treatment of cancer. The recent discovery that radiotherapy can have anticancer effects on the immune system has led to recognition of its ability to sensitize the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bbe8833f9b7b78380ce1989729c620
https://doi.org/10.1158/1078-0432.c.6528273
https://doi.org/10.1158/1078-0432.c.6528273