Analysis of CDK12 alterations in a pan‐cancer database

Autor: Elizabeth Pan, Angelo Cabal, Juan Javier‐DesLoges, Devin Patel, Justine Panian, Suzanna Lee, Justin Shaya, Taylor Nonato, Xiaojun Xu, Tyler Stewart, Brent Rose, Ahmed Shabaik, Ezra Cohen, Razelle Kurzrock, Pablo Tamayo, Rana R. McKay

Publikováno v: Cancer Medicine, Vol 11, Iss 3, Pp 753-763 (2022)

Abstract Background CDK12 inactivation leading to increased neoantigen burden has been hypothesized to sensitize tumors to immune checkpoint inhibition. Pan‐cancer data regarding the frequency of CDK12 alterations are limited. We aimed to character

Externí odkaz: https://doaj.org/article/d6e00a346dab47b4a990756e8c90935e

Safety and Activity of Immune Checkpoint Inhibitors in People Living With HIV and Cancer: A Real-World Report From the Cancer Therapy Using Checkpoint Inhibitors in People Living With HIV-International (CATCH-IT) Consortium

Autor: Talal El Zarif, Amin H. Nassar, Elio Adib, Bailey G. Fitzgerald, Jiaming Huang, Tarek H. Mouhieddine, Paul G. Rubinstein, Taylor Nonato, Rana R. McKay, Mingjia Li, Arjun Mittra, Dwight H. Owen, Robert A. Baiocchi, Michael Lorentsen, Christopher Dittus, Nazli Dizman, Adewunmi Falohun, Noha Abdel-Wahab, Adi Diab, Anand Bankapur, Alexandra Reed, Chul Kim, Aakriti Arora, Neil J. Shah, Edward El-Am, Elie Kozaily, Wassim Abdallah, Ahmad Al-Hader, Batool Abu Ghazal, Anwaar Saeed, Claire Drolen, Melissa G. Lechner, Alexandra Drakaki, Javier Baena, Caroline A. Nebhan, Tarek Haykal, Michael A. Morse, Alessio Cortellini, David J. Pinato, Alessia Dalla Pria, Evan Hall, Veli Bakalov, Nathan Bahary, Aarthi Rajkumar, Ankit Mangla, Vishal Shah, Parminder Singh, Frank Aboubakar Nana, Nerea Lopetegui-Lia, Danai Dima, Ryan W. Dobbs, Pauline Funchain, Rabia Saleem, Rachel Woodford, Georgina V. Long, Alexander M. Menzies, Carlo Genova, Giulia Barletta, Sonam Puri, Vaia Florou, Dame Idossa, Maristella Saponara, Paola Queirolo, Giuseppe Lamberti, Alfredo Addeo, Melissa Bersanelli, Dory Freeman, Wanling Xie, Erin G. Reid, Elizabeth Y. Chiao, Elad Sharon, Douglas B. Johnson, Ramya Ramaswami, Mark Bower, Brinda Emu, Thomas U. Marron, Toni K. Choueiri, Lindsey R. Baden, Kathryn Lurain, Guru P. Sonpavde, Abdul Rafeh Naqash

Publikováno v: Journal of Clinical Oncology.

PURPOSE Compared with people living without HIV (PWOH), people living with HIV (PWH) and cancer have traditionally been excluded from immune checkpoint inhibitor (ICI) trials. Furthermore, there is a paucity of real-world data on the use of ICIs in P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dd2df1f220f7a099fa94544d9c68975
https://doi.org/10.1200/jco.22.02459

Asymptomatic detection of SARS‐CoV‐2 among cancer patients receiving infusional anti‐cancer therapy

Autor: Scott M. Lippman, Taylor Nonato, Assuntina G. Sacco, Joseph A. Califano, Rana R. McKay, Justin Shaya, Francesca J. Torriani, Angelo Cabal

Publikováno v: Cancer Medicine
Cancer Medicine, Vol 10, Iss 24, Pp 8763-8767 (2021)

Background Little is known regarding the rate and clinical outcomes of asymptomatic carriers of SARS‐CoV‐2 among patients with cancer. Detection of asymptomatic carriers is important in this population given the use of myelosuppressive and immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969f7e76b389686f39f28cd14ac7a528
https://doi.org/10.1002/cam4.4373

The Prognostic Significance of Homologous Recombination Repair Pathway Alterations in Metastatic Hormone Sensitive Prostate Cancer

Autor: Aaron M. Lee, Ava Saidian, Justin Shaya, Taylor Nonato, Angelo Cabal, J. Michael Randall, Frederick Millard, Tyler Stewart, Brent Rose, Pablo Tamayo, Rana R. McKay

Publikováno v: Clin Genitourin Cancer

Data regarding the clinical outcomes of men with metastatic hormone sensitive prostate cancer (mHSPC) who harbor homologous recombination repair (HRR) gene alterations have not been fully characterized. Here, we examine a cohort of mHSPC patients who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cfd569e7501ba09a905254939c0573
https://europepmc.org/articles/PMC10257153/

Analysis of the Prognostic Significance of Circulating Tumor DNA in Metastatic Castrate Resistant Prostate Cancer

Autor: Tyler F. Stewart, Angelo Cabal, Justin Shaya, Frederick Millard, Taylor Nonato, James Michael Randall, Rana R. McKay

Publikováno v: Clinical genitourinary cancer. 19(6)

There has been considerable interest in ctDNA next generation sequencing platforms to assess genomic alterations in mCRPC given its accessibility and identification of temporal genomic data.In this retrospective analysis, we analyzed 63 patients who

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8672ca174da1255a3bc99c0f1d37f8
https://pubmed.ncbi.nlm.nih.gov/34452870