Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Taylor McClatchie"'
Publikováno v:
Cells, Vol 12, Iss 20, p 2500 (2023)
Early preimplantation mouse embryos are sensitive to increased osmolarity, which can block their development. To overcome this, they accumulate organic osmolytes to maintain cell volume. The main organic osmolyte used by early mouse embryos is glycin
Externí odkaz:
https://doaj.org/article/bde4555eb1b24d27a5aa92e13c11bff3
Autor:
Kyla Young, Allison K. Tscherner, Baohua Zhang, Megan Meredith, Taylor McClatchie, Jacquetta M. Trasler, Jay M. Baltz
Publikováno v:
Zygote. 30:674-688
SummaryThe enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) links the folate cycle that produces one-carbon units with the methionine cycle that converts these into S-adenosylmethionine (SAM), the universal methyl donor for almost all methyltr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a47e866a840bb42dff0c8e8feed602c
https://doi.org/10.1017/s0967199422000156
https://doi.org/10.1017/s0967199422000156
Autor:
Gurbet Karahan, Kenjiro Shirane, Jay M. Baltz, Matthew C. Lorincz, Taylor McClatchie, Sanne M. Janssen, Jacquetta M. Trasler, Donovan Chan
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimuta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0c3b783c67ef5dfe7337c62b41c51f
http://europepmc.org/articles/PMC8276981
http://europepmc.org/articles/PMC8276981
Autor:
Taylor McClatchie, Megan Meredith, Mariame O. Ouédraogo, Sandy Slow, Michael Lever, Mellissa R.W. Mann, Steven H. Zeisel, Jacquetta M. Trasler, Jay M. Baltz
Publikováno v:
The Journal of biological chemistry. 295(31)
Betaine (N,N,N-trimethylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of cell volume regulation and second as a major methyl donor in blastocysts, but its origin is unknown. Here, we determined that end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07672e5a9aa7a9bf490ee7e09d1f1fc2
https://pubmed.ncbi.nlm.nih.gov/28663368
https://pubmed.ncbi.nlm.nih.gov/28663368
Publikováno v:
Journal of cellular physiologyREFERENCES. 235(11)
Serine has roles in cell metabolism besides protein synthesis including providing one-carbon units to the folate cycle. Since growing mouse oocytes undergo a burst of folate accumulation as they near full size, we have investigated whether oocytes tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6616a45a2b2f306a6e9ac55e6eb3237
https://pubmed.ncbi.nlm.nih.gov/32329057
https://pubmed.ncbi.nlm.nih.gov/32329057
Autor:
Taylor McClatchie, Jay M. Baltz, Megan Meredith, Michael Lever, Sandy Slow, Jacquetta M. Trasler, Steven H. Zeisel, Mariame Ouedraogo, Mellissa R.W. Mann
Publikováno v:
J Biol Chem
Betaine (N,N,N-trimethylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of cell volume regulation and second as a major methyl donor in blastocysts, but its origin is unknown. Here, we determined that end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1604fe42f0a90408689b161660fa21ce
https://doi.org/10.1074/jbc.m117.803080
https://doi.org/10.1074/jbc.m117.803080