Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Taylor M. Courtney"'
Autor:
Taylor M. Courtney, Alexander Deiters
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Protein phosphatases play an essential role in signal transduction, but are understudied due to the difficulties in detecting phosphate removal and the lack of good inhibitors. Here the authors develop a light-activated protein phosphatase using phot
Externí odkaz:
https://doaj.org/article/27c7f695325c479fbb77f72e954f51e9
Publikováno v:
Biochemistry. 61:2687-2697
Signal transduction pathways are responsible for maintaining cellular functions, including proliferation, differentiation, apoptosis, and cell cycle progression. These pathways are maintained through the propagation of phosphorylation signals by prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9179baab7d26b4808cbc99d46cbe1d8f
https://doi.org/10.1021/acs.biochem.2c00387
https://doi.org/10.1021/acs.biochem.2c00387
Publikováno v:
ACS Chemical Biology. 16:2434-2443
Rapamycin-induced dimerization of FKBP and FRB is the most commonly utilized chemically induced protein dimerization system. It has been extensively used to conditionally control protein localization, split-enzyme activity, and protein-protein intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1438b466a40e92aaaca9ed6d454cd0
https://doi.org/10.1021/acschembio.1c00547
https://doi.org/10.1021/acschembio.1c00547
Publikováno v:
Chemical Science
Chemically induced dimerization of FKBP and FRB using rapamycin and rapamycin analogs has been utilized in a variety of biological applications. Formation of the FKBP-rapamycin-FRB ternary complex is typically used to activate a biological process an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb14d77da75e1f669f9bf9fa59caaf6a
http://europepmc.org/articles/PMC8528027
http://europepmc.org/articles/PMC8528027
Autor:
Amy Ryan, Wenyuan Zhou, Karsen E. Shoger, Taylor M. Courtney, Rachel A. Gottschalk, Alexander Deiters
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40c9170428d016d80b6c22a655d339f8
https://doi.org/10.1096/fasebj.2022.36.s1.l7510
https://doi.org/10.1096/fasebj.2022.36.s1.l7510
Autor:
Taylor M. Courtney, Alexander Deiters
Publikováno v:
SLAS Discovery. 25:957-960
Protein phosphatases play an essential role in cell signaling; however, they remain understudied compared with protein kinases, in part due to a lack of appropriate tools. In order to provide conditional control over phosphatase function, we develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d648ef94539b750ac174ab9d124cb7cf
https://doi.org/10.1177/2472555220918519
https://doi.org/10.1177/2472555220918519
Autor:
Alexander Deiters, Taylor M. Courtney
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Protein phosphatases are involved in embryonic development, metabolic homeostasis, stress response, cell cycle transitions, and many other essential biological mechanisms. Unlike kinases, protein phosphatases remain understudied and less characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9399956157e0ac07c47421b0fd7f0f10
https://doaj.org/article/27c7f695325c479fbb77f72e954f51e9
https://doaj.org/article/27c7f695325c479fbb77f72e954f51e9
Publikováno v:
Organic & Biomolecular Chemistry. 17:8348-8353
Rapamycin-induced dimerization of FKBP and FRB has been utilized as a tool for co-localizing two proteins of interest in numerous applications. Due to the tight binding interaction of rapamycin with FKBP and FRB, the ternary complex formation is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e8bf63e5e218905b97ce62466fae70
https://doi.org/10.1039/c9ob01719d
https://doi.org/10.1039/c9ob01719d
Autor:
Taylor M. Courtney, Alexander Deiters
Publikováno v:
Current Opinion in Chemical Biology. 46:99-107
In nature, biological processes are regulated with precise spatial and temporal resolution at the molecular, cellular, and organismal levels. In order to perturb and manipulate these processes, optically controlled chemical tools have been developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223f6e4f24caaf55c342b11cde3433c5
https://doi.org/10.1016/j.cbpa.2018.07.011
https://doi.org/10.1016/j.cbpa.2018.07.011
Publikováno v:
Angewandte Chemie International Edition. 57:2768-2798
Biological processes are naturally regulated with high spatial and temporal control, as is perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively utilized in cell and developmental biology to investigate cellular process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930e7ad6148fb864301b7118f1aa8cd5
https://doi.org/10.1002/anie.201700171
https://doi.org/10.1002/anie.201700171