Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Taylor L Graham"'
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti
Externí odkaz:
https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
Autor:
Xin Zeng, Robert Kirkpatrick, Glenn Hofmann, Didier Grillot, Valerie Linhart, Fabrice Viviani, Joseph Marino, Joseph Boyer, Taylor L Graham, Quinn Lu, Zining Wu, Andrew Benowitz, Rick Cousins
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0207140 (2018)
Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestina
Externí odkaz:
https://doaj.org/article/656109b149fa41a9b622668bf276f068
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu
Externí odkaz:
https://doaj.org/article/ee8d0f7b2ad14f48b638c180d558c296
Autor:
Jeffrey A. Messer, Yun Ding, Jianghe Deng, Paolo A. Centrella, Todd L. Graybill, Jean Zhang, Patti McCormick, Carl A. Machutta, Robert H. Bates, John Martin, Joël Lelièvre, Quinn Lu, Jingye Zhou, Alfonso Mendoza-Losana, Xiaopeng Bai, Christopher S. Kollmann, David J. Holmes, Keith Rafferty, Christina S. Pao, Christopher C. Arico-Muendel, Heather O’Keefe, Aaron Coffin, Taylor L. Graham, David Barros-Aguirre, Sandy Chang, Christopher P. Davie, Hongwei Qi, Flora S. Sundersingh, Minghui Wang, Karen A. Ingraham, Jing Chai, Thomas O’Keeffe, Juan Wang, Gang Yao, Lluis Ballell, Jianzhong Huang, Anthony E. Choudhry, Bryan W. King, Andrew J. Pope, Ghotas Evindar, Xiaorong Liu, May Fern Toh, Christine Patricia Donahue, Jeffrey W. Gross, Pan F. Chan, Walter P. Johnson, Ruth Lehr, Hongfeng Deng, Kenneth E Lind, Matt S. Steiginga, Jason W. Dodson, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Yue Li, Lawrence M. Szewczuk, Svetlana L. Belyanskaya, Genaro S. Scavello, Sharon Sweitzer, Christopher R. Kwiatkowski, Lynn McCloskey, Bing Xia, Enoch Gao, Christopher B. Phelps, David T. Fosbenner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87eaf46a6638b2650fa3a4f95e4cf2b
https://doi.org/10.1038/ncomms16227
https://doi.org/10.1038/ncomms16227
Autor:
Fabrice Viviani, Glenn A. Hofmann, Joseph P. Marino, Valerie Linhart, Didier Grillot, Quinn Lu, Zining Wu, Robert B. Kirkpatrick, Taylor L. Graham, Rick P. C. Cousins, Xin Zeng, Joseph Boyer, Andrew B. Benowitz
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0207140 (2018)
PLoS ONE, Vol 13, Iss 12, p e0207140 (2018)
Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78adafc9a1df20231b02a72be255f50a
https://pubmed.ncbi.nlm.nih.gov/30540745
https://pubmed.ncbi.nlm.nih.gov/30540745
Autor:
Thomas D. Sweitzer, Ed Dul, Quinn Lu, Robert S. Ames, Wensheng Xie, Hu Li, Christina S. Pao, Taylor L. Graham
Publikováno v:
ASSAY and Drug Development Technologies. 10:514-524
Nuclear-factor-E2-related transcription factor 2 (Nrf2) regulates a large panel of Phase II genes and plays an important role in cell survival. Nrf2 activation has been shown as preventing cigarette smoke-induced alveolar enlargement in mice. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d29ad14aabc3578c876f193c95e77a
https://doi.org/10.1089/adt.2011.436
https://doi.org/10.1089/adt.2011.436
Autor:
Todd L. Graybill, John D. Martin, Jason W. Dodson, Hongfeng Deng, Christopher P. Davie, Christopher C. Arico-Muendel, Minghui Wang, Hongwei Qi, Sandy S. Chang, David J. Holmes, Karen A. Ingraham, Kenneth E Lind, Heather O’Keefe, Carl A. Machutta, David Barros-Aguirre, Christine Patricia Donahue, Christina S. Pao, Jeffrey W. Gross, Ghotas Evindar, Jean Zhang, Bing Xia, Juan Wang, Patti McCormick, Xiaorong Liu, Jianzhong Huang, Joël Lelièvre, Quinn Lu, Pan F. Chan, Matt S. Steiginga, Lynn McCloskey, Christopher S. Kollmann, Taylor L. Graham, Xiaopeng Bai, Jing Chai, Yue Li, Walter P. Johnson, Ruth Lehr, Lawrence M. Szewczuk, Jingye Zhou, Lluis Ballell, Genaro S. Scavello, Robert H. Bates, Anthony E. Choudhry, Aaron Coffin, Sharon Sweitzer, Christopher R. Kwiatkowski, Andrew J. Pope, Enoch Gao, Christopher B. Phelps, David T. Fosbenner, Keith Rafferty, Thomas O’Keeffe, Gang Yao, Bryan W. King, Svetlana L. Belyanskaya, May Fern Toh, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Alfonso Mendoza-Losana, Paolo A. Centrella, Flora S. Sundersingh, Jeffrey A. Messer, Yun Ding, Jianghe Deng
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd5399c3ed244a244dc84c19085f169
https://pubmed.ncbi.nlm.nih.gov/30004092
https://pubmed.ncbi.nlm.nih.gov/30004092
Autor:
Thomas D. Meek, Frank M. Raushel, Hongwei Qi, Huizhen Zhao, Joseph Boyer, Benjamin Schwartz, Taylor L. Graham, Howard J. Williams, Fan Fan, Ruth Lehr
Publikováno v:
Biochemistry. 51:5198-5211
ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA). Studies were performed with recombinant human ACL to ascertain the nature of the catalytic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1648ad6d4adae85b07ae570f71bdd887
https://doi.org/10.1021/bi300611s
https://doi.org/10.1021/bi300611s
Autor:
John J. Kerrigan, Dulcie B. Schmidt, James J. Foley, Abby J. Sukman, Tia Lewis, Patrick McDevitt, Kathleen T. Gallagher, Kyung O. Johanson, Robert S. Ames, James A. Fornwald, Taylor L. Graham, Matthew C. Burns, Quinn Lu, Xiaoyan Tang, Gerald E. Hunsberger
Publikováno v:
Protein Expression and Purification. 65:251-260
We describe here two strategies to produce biologically active chemokines with authentic N-terminal amino acid residues. The first involves producing the target chemokine with an N-terminal 6×His-SUMO tag in Escherichia coli as inclusion bodies. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951418dee127686dd1f484c032678731
https://doi.org/10.1016/j.pep.2009.01.017
https://doi.org/10.1016/j.pep.2009.01.017
Autor:
Lisa A. Payne, Nambi V. Aiyar, Zhaohui Ao, Douglas G. Johns, Quinn Lu, Nabil Elshourbagy, Taylor L. Graham, Bradley J. Heidrich, Stephen A. Douglas, Gerald E. Hunsberger
Publikováno v:
Biochemical and Biophysical Research Communications. 358:145-149
Dendroaspis natriuretic peptide (DNP) is a newly-described natriuretic peptide which lowers blood pressure via vasodilation. The natriuretic peptide clearance receptor (NPR-C) removes natriuretic peptides from the circulation, but whether DNP interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c319378bc978f812c096a063293d5f
https://doi.org/10.1016/j.bbrc.2007.04.079
https://doi.org/10.1016/j.bbrc.2007.04.079