Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata

Autor: Mark V. Horton, Chad J. Johnson, Robert Zarnowski, Brody D. Andes, Taylor J. Schoen, John F. Kernien, Douglas Lowman, Michael D. Kruppa, Zuchao Ma, David L. Williams, Anna Huttenlocher, Jeniel E. Nett

Publikováno v: mSphere, Vol 6, Iss 3 (2021)

The emerging fungal pathogen Candida auris

Externí odkaz: https://doaj.org/article/60c29a0578ed4e0d8df13d3f69f173c0

Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils

Autor: Emily C. Britt, Jorgo Lika, Morgan A. Giese, Taylor J. Schoen, Gretchen L. Seim, Zhengping Huang, Pui Y. Lee, Anna Huttenlocher, Jing Fan

Publikováno v: Nature Metabolism. 4:389-403

Neutrophils are cells at the frontline of innate immunity that can quickly activate effector functions to eliminate pathogens upon stimulation. However, little is known about the metabolic adaptations that power these functions. Here we show rapid me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a7dcf594f502c62902d5a035fb0a855
https://doi.org/10.1038/s42255-022-00550-8

Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model

Autor: Laurel E. Hind, Anna Huttenlocher, Morgan A Giese, Taylor J. Schoen, David J. Beebe, Nancy P. Keller

Publikováno v: Cellular and Molecular Bioengineering. 14:133-145

Neutrophils act as first responders during an infection, following signals from the pathogen as well as other host cells to migrate from blood vessels to the site of infection. This tightly regulated process is critical for pathogen clearance and, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb799794f14f4c567f60ce5e1b7d7a75
https://doi.org/10.1007/s12195-020-00655-8

Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata

Autor: Chad J. Johnson, Taylor J. Schoen, Robert Zarnowski, Michael Kruppa, Jeniel E. Nett, Anna Huttenlocher, John F. Kernien, Mark V. Horton, Zuchao Ma, David L. Williams, Brody D Andes, Douglas W. Lowman

Publikováno v: mSphere, Vol 6, Iss 3 (2021)
mSphere

Candida auris, a recently emergent fungal pathogen, has caused invasive infections in health care settings worldwide. Mortality rates approach 60% and hospital spread poses a public health threat. Compared to other Candida spp., C. auris avoids trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ce2abb235540c830b8aec58ad549cdd
https://doi.org/10.1128/msphere.00406-21

Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans

Autor: Gustavo H. Goldman, Ian D. Reid, Verônica Soares Brauer, Jacob L. Steenwyk, Laure Nicolas Annick Ries, Anna Huttenlocher, Clara Valero, Rafael Silva-Rocha, Fausto Almeida, Marina Marcet-Houben, Berl R. Oakley, Nancy P. Keller, Flávio V. Loures, Fernando Rodrigues, Katrien Lagrou, Abigail L. Lind, Adrian Tsang, Erin McDonnell, Lilian Pereira Silva, Agustin Resendiz-Sharpe, Toni Gabaldón, Taylor J. Schoen, Rafael Wesley Bastos, Antonis Rokas, Milton T. Drott

Publikováno v: mSphere
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
mSphere, Vol 5, Iss 2, p e00153-20 (2020)
mSphere, Vol 5, Iss 2 (2020)

Immunocompromised patients are susceptible to infections with opportunistic filamentous fungi from the genus Aspergillus. Although A. fumigatus is the main etiological agent of Aspergillus species-related infections, other species, such as A. nidulan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42eb96e6b80d0d9f06b1be955fbe8575
https://lirias.kuleuven.be/handle/123456789/653148