Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Taylor J. Evers"'
Autor:
G. Prabhakar Reddy, Randy B. Howard, Richard F. Arrendale, David S. Menaldino, Sarah T. Pruett, Manohar Saindane, Dennis C. Liotta, Mark T. Baillie, Jason J. Holt, Deborah G. Culver, John A. Petros, Eric J. Miller, Michael G. Natchus, Taylor J. Evers, Suzanne G. Mays
Publikováno v:
ACS Medicinal Chemistry Letters. 7:537-542
The orally bioavailable 1-deoxy-sphingosine analog, Enigmol, has demonstrated anticancer activity in numerous in vivo settings. However, as no Enigmol analog with enhanced potency in vitro has been identified, a new strategy to improve efficacy in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f8cc417011a9fe835509db03dfa969
https://doi.org/10.1021/acsmedchemlett.6b00113
https://doi.org/10.1021/acsmedchemlett.6b00113
Autor:
David B. Guthrie, Richard F. Arrendale, Dennis C. Liotta, Fahim Atif, Randy B. Howard, Michael G. Natchus, Donald G. Stein, Deborah G. Culver, Jose R. Marengo, Mark A. Lockwood, G. Prabhakar Reddy, Iqbal Sayeed, Taylor J. Evers
Publikováno v:
ACS Medicinal Chemistry Letters. 3:362-366
After more than 30 years of research and 30 failed clinical trials with as many different treatments, progesterone is the first agent to demonstrate robust clinical efficacy as a treatment for traumatic brain injuries. It is currently being investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0189124b6b0aae85a83e76d1247dd58
https://doi.org/10.1021/ml200303r
https://doi.org/10.1021/ml200303r
Autor:
Jason J. Holt, John A. Petros, Anatoliy S. Bushnev, David S. Menaldino, Richard F. Arrendale, Lanny S. Liebeskind, Taylor J. Evers, Deborah G. Culver, G. Prabhakar Reddy, Suzanne G. Mays, Dennis C. Liotta, Mark T. Baillie, Randy B. Howard, Michael G. Natchus, Harsha Ramaraju, Ethel C. Garnier-Amblard
Publikováno v:
ACS Medicinal Chemistry Letters. 2:438-443
Enigmol is a synthetic, orally active 1-deoxysphingoid base analogue that has demonstrated promising activity against prostate cancer. In these studies, the pharmacologic roles of stereochemistry and N-methylation in the structure of enigmols were ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5ee2a7ea75912e9db3c96fd6717af
https://doi.org/10.1021/ml2000164
https://doi.org/10.1021/ml2000164
Autor:
Don VanDerveer, Benjamin E. Huck, Javier J. Concepcion, Daniel J. Williams, Mark S. Wilson, Lindsey M. Bloodworth, Kimberly A. Arrowood, Angela L. Carmack, Carol A. Brevett, Taylor J. Evers, Daniel Gulla
Publikováno v:
Journal of Chemical Crystallography. 39:581-584
A new compound, [Cd(mipit)4][PF6]2 has been synthesized and characterized via standard solid and solution state methods including single crystal X-ray crystallography (mipit = 1-methyl-3-(2-propyl)-2(3H)-imidazolethione). The title compound crystalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a456984fe2391ca75cec7c772dd8ecd9
https://doi.org/10.1007/s10870-009-9528-x
https://doi.org/10.1007/s10870-009-9528-x
Autor:
G. Prabhakar Reddy, Richard K. Plemper, Richard F. Arrendale, Elise S Hovingh, Veronika von Messling, Dan Yan, George R. Painter, Theresa Enkirch, Stefanie A. Krumm, Dennis C. Liotta, Manohar Saindane, Aiming Sun, Taylor J. Evers, Michael G. Natchus
Publikováno v:
Science Translational Medicine. 6
Measles virus is a highly infectious morbillivirus responsible for major morbidity and mortality in unvaccinated humans. The related, zoonotic canine distemper virus (CDV) induces morbillivirus disease in ferrets with 100% lethality. We report an ora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e072a76243ace6ff596c79cde5ac547e
https://doi.org/10.1126/scitranslmed.3008517
https://doi.org/10.1126/scitranslmed.3008517
Autor:
Richard F. Arrendale, Nao Morii, Randy B. Howard, James P. Snyder, Deborah G. Culver, Dong M. Shin, Aiming Sun, Shijun Zhu, Fadlo R. Khuri, Hongzheng Zhang, Gabriel Sica, Haian Fu, Taylor J. Evers, Mamoru Shoji, Prabhakar Reddy, Zhuo Georgia Chen, Terry W. Moore
Publikováno v:
Current cancer drug targets. 14(4)
The natural compound curcumin has been investigated as an anticancer agent in many cellular systems, in animal models and in the clinic. The overriding negative characteristics of curcumin are its low solubility, weak potency and poor bioavailability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4919f3db475222ad09bf7f7a6ace449
https://pubmed.ncbi.nlm.nih.gov/24628271
https://pubmed.ncbi.nlm.nih.gov/24628271
Autor:
John A. Petros, Mark Baillie, Jingjing Gao, Taylor J. Evers, Michael G. Natchus, Eric J. Miller, Deborah G. Culver, Richard F. Arrendale, Suzanne G. Mays, G. Prakabahr Reddy, Randy B. Howard, Sarah T. Pruett, Anatoliy S. Bushnev, Dennis C. Liotta
Publikováno v:
Journal of Urology. 189
INTRODUCTION AND OBJECTIVES: Retroviral replicating vectors (RRVs) represent a novel gene delivery platform that can achieve efficient transduction of solid tumors through virus propagation within actively dividing cancer cells. FDA has already appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313c4b791d36ef79789338f9b088802b
https://doi.org/10.1016/j.juro.2013.02.1715
https://doi.org/10.1016/j.juro.2013.02.1715
Autor:
Prabhakar Reddy, Aiming Sun, Xiaoqian Lin, Taylor J. Evers, Terry W. Moore, Dong M. Shin, Nao Morii, Hongzheng Zhang, Alessandra Mancini, Richard F. Arrendale, Zhuo Georgia Chen, Randy B. Howard, Mamoru Shoji, Fadlo R. Khuri, James P. Snyder, Shijun Zhu, Deborah G. Culver, Gabriel Sica, Haian Fu
Publikováno v:
Integrative biology : quantitative biosciences from nano to macro. 4(6)
Objectives are to examine the efficacy of new synthetic curcumin analogs EF31 in head and neck squamous cell carcinoma in vitro and in vivo, and study their pharmacokinetic and toxicologic effects in vivo. The synthesis of EF31 was described for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827d2defcb6248fc0b94681d9e97f238
https://pubmed.ncbi.nlm.nih.gov/22532032
https://pubmed.ncbi.nlm.nih.gov/22532032
Autor:
Dan Yan, Randy B. Howard, Stefanie A. Krumm, J. Maina Ndungu, Dennis C. Liotta, Michael G. Natchus, James P. Snyder, Taylor J. Evers, G. Prabhakar Reddy, Richard K. Plemper, Richard F. Arrendale, Manohar Saindane, Aiming Sun
The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide therapeutic treatments for improved measles management, we previously identified a small, non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9e20429b8594a164c3596212dafdda
https://europepmc.org/articles/PMC3701436/
https://europepmc.org/articles/PMC3701436/
Autor:
Jason J. Holt, Esmeralda V. S. Meyer, Deborah G. Culver, Mark T. Ballie, G. Prabhakar Reddy, Dennis C. Liotta, Kathryn R. Girard, David S. Menaldino, Randy B. Howard, Anatoliy S. Bushnev, Taylor J. Evers, Stacey A. Lapp, Mary R. Galinski, Richard F. Arrendale, Michael G. Natchus
Publikováno v:
ACS medicinal chemistry letters. 3(1)
Plasmodium-infected erythrocytes have been shown to employ sphingolipids from both endogenous metabolism as well as existing host pools. Therapeutic agents that limit these supplies have thus emerged as intriguing, mechanistically distinct putative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1384c7cb49dd55c2bb0f648ba72068
https://pubmed.ncbi.nlm.nih.gov/24900369
https://pubmed.ncbi.nlm.nih.gov/24900369