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Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
Autor:
Mack Sobhany, Gonzalo Riadi, Janine H. Santos, Oswaldo A. Lozoya, Douglas Ganini da Silva, Taylor C. Wolfgang, Tianyuan Wang, Navdeep S. Chandel, Dagoberto Grenet, Richard P. Woychik
Publikováno v:
Life Science Alliance
This study shows that genetic or pharmacological manipulation of the TCA cycle, when mitochondria are dysfunctional, can modulate histone acetylation and gene expression in the nucleus with physiological outcomes.
The impact of mitochondrial dys
The impact of mitochondrial dys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3771e28caf3af5e52e3d20941dd6d55f
https://pubmed.ncbi.nlm.nih.gov/30737248
https://pubmed.ncbi.nlm.nih.gov/30737248
