Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Taylor Broda"'
Autor:
Loryn Holokai, Jayati Chakrabarti, Taylor Broda, Julie Chang, Jennifer A Hawkins, Nambirajan Sundaram, Lydia E Wroblewski, Richard M Peek, Jiang Wang, Michael Helmrath, James M Wells, Yana Zavros
Publikováno v:
PLoS Pathogens, Vol 15, Iss 1, p e1007468 (2019)
Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H.
Externí odkaz:
https://doaj.org/article/0ccabb3aad4a496e83ca473aeab518db
Autor:
Timothy C. Wang, Misty Troutt, W. Clark Bacon, Michael A. Helmrath, Joyce C. Niland, Magdalena Kasendra, Taylor Broda
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Recent advances in intestinal organoid research, along with encouraging preclinical proof-of-concept studies, have revealed significant therapeutic potential for induced pluripotent stem cell (iPSC)-derived organoids in the healing and replacement of
Autor:
Suengwon Lee, James M. Wells, Jennifer Hawkins, Krithika R Subramanian, Andrew E. Rosselot, Gang Wu, John B. Hogenesch, Nathan Salomonis, Michael A. Helmrath, Nambirajan Sundaram, Danilo E. F. L. Flôres, Sean R. Moore, Christian I. Hong, Toru Matsu-ura, Miri Park, Heather A. McCauley, Kashish Chetal, Noah F. Shroyer, Taylor Broda
Publikováno v:
The EMBO Journal
Circadian rhythms regulate diverse aspects of gastrointestinal physiology ranging from the composition of microbiota to motility. However, development of the intestinal circadian clock and detailed mechanisms regulating circadian physiology of the in
Autor:
Mansa Krishnamurthy, Daniel O. Kechele, Taylor Broda, Xinghao Zhang, Jacob R. Enriquez, Heather A. McCauley, J. Guillermo Sanchez, Kyle McCracken, Joseph Palermo, Anas Bernieh, Margaret H. Collins, Inas H. Thomas, Haley C. Neef, Amer Heider, Andrew Dauber, James M. Wells
Publikováno v:
Gastroenterology. 163:1053-1063.e7
Two patients with homozygous mutations in PDX1 presented with pancreatic agenesis, chronic diarrhea, and poor weight gain, the causes of which were not identified through routine clinical testing. We aimed to perform a deep analysis of the stomach an
Publikováno v:
Nat Protoc
The human stomach contains two primary domains: the corpus, which contains the fundic epithelium, and the antrum. Each of these domains has distinct cell types and functions, and therefore each presents with unique disease pathologies. Here, we detai
Autor:
James M. Wells, Mansa Krishnamurthy, Margaret H. Collins, Haley C Neef, Heather A. McCauley, Joseph J. Palermo, Inas H. Thomas, Xinghao Zhang, Jacob R. Enriquez, Amer Heider, J. Guillermo Sanchez, Taylor Broda, Daniel O Kechele, Andrew Dauber
SummaryTwo patients with mutations in PDX1 presented with pancreatic agenesis, chronic diarrhea and poor weight gain, the causes of which were not identified through routine clinical testing. We generated patient derived organoids as a novel diagnost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8debc211658ceb83097dc073c0947558
https://doi.org/10.1101/2021.04.25.441341
https://doi.org/10.1101/2021.04.25.441341
Autor:
Taylor Broda, Alexandra Calor, Xiaowen Cheng, Mahmoud I. Elbadry, Ahmed El-Hashash, Adegbenro Omotuyi John Fakoya, Deming Jiang, Magdalena Kasendra, Jingwen Liu, Mahmoud Shaaban Mohamed, Cynthia Oghenekome Okaruefe, Adekunle Ebenezer Omole, Nihal Satyadev, Stefania Senger, Mirjam van Weissenbruch, Yiyi Yang, Chao-Ling Yao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3506a1d0030caa517b1c72740165be5
https://doi.org/10.1016/b978-0-12-821269-1.00016-3
https://doi.org/10.1016/b978-0-12-821269-1.00016-3
Organotypic intestinal cell culture as a new modality for intestinal function and cellular processes
Autor:
Magdalena Kasendra, Taylor Broda
In recent years the advent of organotypic intestinal culture systems has revolutionized studies of intestinal function and cellular processes. These self-organizing and self-renewing organ-like cultures are derived from primary human donor tissue or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec3693bfba72c42f71d21c78fe3e6cc
https://doi.org/10.1016/b978-0-12-821269-1.00004-7
https://doi.org/10.1016/b978-0-12-821269-1.00004-7
Autor:
Andrew E. Rosselot, Taylor Broda, James M. Wells, Christian I. Hong, Toru Matsu-ura, Kang Kug Paul Lee
Publikováno v:
Biomicrofluidics
Perfused three-dimensional (3D) cultures enable long-term in situ growth and monitoring of 3D organoids making them well-suited for investigating organoid development, growth, and function. One of the limitations of this long-term on-chip perfused 3D
Autor:
Christian I. Hong, James M. Wells, Taylor Broda, Kang Kug Lee, Matthew J. Kofron, Heather A. McCauley
Publikováno v:
Lab on a Chip. 18:3079-3085
Current in vitro approaches and animal models have critical limitations for modeling human gastrointestinal diseases because they may not properly represent multicellular human primary tissues. Therefore, there is a need for model platforms that reca