Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Taylor B. Engdahl"'
Autor:
Ivan V. Kuzmin, Ruben Soto Acosta, Layne Pruitt, Perry T. Wasdin, Kritika Kedarinath, Keziah R. Hernandez, Kristyn A. Gonzales, Kharighan Hill, Nicole G. Weidner, Chad Mire, Taylor B. Engdahl, Woohyun J. Moon, Vsevolod Popov, James E. Crowe, Ivelin S. Georgiev, Mariano A. Garcia-Blanco, Robert K. Abbott, Alexander Bukreyev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular uridine (U-mRNA) or N1-methylpseudouridine (m1Ψ-mRNA). Female mice immu
Externí odkaz:
https://doaj.org/article/b9d9f5258a8943afbcc90d9e051b9c63
Autor:
Nathaniel S. Chapman, Ruben J. G. Hulswit, Jonna L. B. Westover, Robert Stass, Guido C. Paesen, Elad Binshtein, Joseph X. Reidy, Taylor B. Engdahl, Laura S. Handal, Alejandra Flores, Brian B. Gowen, Thomas A. Bowden, James E. Crowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we describe a dual-mechanism human monoclonal antibody (mAb) combination against RVFV
Externí odkaz:
https://doaj.org/article/b9951ffe5c244d7b912906b85005d70b
Autor:
Alex W. Wessel, Michael P. Doyle, Taylor B. Engdahl, Jessica Rodriguez, James E. Crowe, Michael S. Diamond
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Therapeutic antibodies against flaviviruses often promote neutralization by targeting the envelope protein of the virion. However, this approach is hindered by a possible concern for antibody-dependent enhancement of infection and paradoxical worseni
Externí odkaz:
https://doaj.org/article/452803504505489b8c84cd953cbd6230
Autor:
Taylor B. Engdahl, Natalia A. Kuzmina, Adam J. Ronk, Chad E. Mire, Matthew A. Hyde, Nurgun Kose, Matthew D. Josleyn, Rachel E. Sutton, Apoorva Mehta, Rachael M. Wolters, Nicole M. Lloyd, Francisca R. Valdivieso, Thomas G. Ksiazek, Jay W. Hooper, Alexander Bukreyev, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109086- (2021)
Summary: New World hantaviruses (NWHs) are endemic in North and South America and cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40%. Knowledge of the natural humoral immune response to NWH infection is limited.
Externí odkaz:
https://doaj.org/article/6188275c140141ab92a3051681cc594b
Autor:
Taylor B. Engdahl, James E. Crowe
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Hantaviruses are zoonotic pathogens found in parts of Europe, Asia, South America, and North America, which can cause renal and respiratory failure with fatality rates up to 40%. There are currently no FDA-approved vaccines or therapeutics f
Externí odkaz:
https://doaj.org/article/f24b533fa7524db0a6a533a0318d4b8c
Autor:
Rebecca L Brocato, Elad Binshtein, Taylor B Engdahl, Natalia A Kuzmina, Lucia M Principe, Steven A Kwilas, Robert K Kim, Nathaniel S Chapman, Monique S Porter, Pablo Guardado-Calvo, Félix A Rey, Laura S Handal, Summer M Diaz, Irene A Zagol-Ikapitte, Minh H Tran, W Hayes McDonald, Jens Meiler, Joseph X Reidy, Andrew Trivette, Alexander Bukreyev, Jay W Hooper, James E Crowe
Publikováno v:
eLife
eLife, 2023, 12, ⟨10.7554/eLife.81743⟩
eLife, 2023, 12, ⟨10.7554/eLife.81743⟩
International audience; Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections in humans are relatively rare, mortality rates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5bfe7749db7fdcccc05740700dacd1
https://hal-pasteur.archives-ouvertes.fr/pasteur-04123202/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-04123202/document
Autor:
Rebecca L Brocato, Elad Binshtein, Taylor B Engdahl, Natalia A Kuzmina, Lucia M Principe, Steven A Kwilas, Robert K Kim, Nathaniel S Chapman, Monique S Porter, Pablo Guardado-Calvo, Félix A Rey, Laura S Handal, Summer M Diaz, Irene A Zagol-Ikapitte, Minh H Tran, W Hayes McDonald, Jens Meiler, Joseph X Reidy, Andrew Trivette, Alexander Bukreyev, Jay W Hooper, James E Crowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2898d4a7ab66a28e0fcccd03e45a64
https://doi.org/10.7554/elife.81743.sa2
https://doi.org/10.7554/elife.81743.sa2
Autor:
Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau, Fangqiang Zhu, Dante Ricci, Stephanie Cronin, Seth J. Zost, Elad Binshtein, Suzanne M. Scheaffer, Bernadeta Dadonaite, Brenden K. Petersen, Taylor B. Engdahl, Elaine Chen, Laura S. Handal, Lynn Hall, John W. Goforth, Denis Vashchenko, Sam Nguyen, Dina R. Weilhammer, Jacky Kai-Yin Lo, Bonnee Rubinfeld, Edwin A. Saada, Tracy Weisenberger, Tek-Hyung Lee, Bradley Whitener, James B. Case, Alexander Ladd, Mary S. Silva, Rebecca M. Haluska, Emilia A. Grzesiak, Christopher G. Earnhart, Svetlana Hopkins, Thomas W. Bates, Larissa B. Thackray, Brent W. Segelke, Antonietta Maria Lillo, Shivshankar Sundaram, Jesse Bloom, Michael S. Diamond, James E. Crowe, Robert H. Carnahan, Daniel M. Faissol
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs1–3, but also revealed how quickly viral escape can curtail effective options4, 5. With the emergence of the SARS-CoV-2 Omicron variant in
Autor:
Taylor B. Engdahl, Elad Binshtein, Rebecca L. Brocato, Natalia A. Kuzmina, Lucia M Principe, Steven A. Kwilas, Robert K. Kim, Nathaniel S. Chapman, Monique S. Porter, Pablo Guardado-Calvo, Felix A. Rey, Laura S. Handal, Summer M. Diaz, Irene A. Zagol-Ikapitte, Joseph X. Reidy, Andrew Trivette, Alexander Bukreyev, Jay W. Hooper, James. E. Crowe
Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person contact. While sporadic in North and South America, many infections occur in Europe and Asia, wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efaa40449c0d4e58e0565078a0cf06a3
https://doi.org/10.1101/2022.07.19.500579
https://doi.org/10.1101/2022.07.19.500579
Autor:
Taylor B. Engdahl, Michael P. Doyle, James E. Crowe, Jessica Rodriguez, Alex W. Wessel, Michael S. Diamond
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
Envelope protein-targeted vaccines for flaviviruses are limited by concerns of antibody-dependent enhancement (ADE) of infections. Nonstructural protein 1 (NS1) provides an alternative vaccine target that avoids this risk since this protein is absent