Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Taylor B. Cavazos"'
Autor:
Taylor B. Cavazos, Linda Kachuri, Rebecca E. Graff, Jovia L. Nierenberg, Khanh K. Thai, Stacey Alexeeff, Stephen Van Den Eeden, Douglas A. Corley, Lawrence H. Kushi, Regeneron Genetics Center, Thomas J. Hoffmann, Elad Ziv, Laurel A. Habel, Eric Jorgenson, Lori C. Sakoda, John S. Witte
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Up to one of every six individuals diagnosed with one cancer will be diagnosed with a second primary cancer in their lifetime. Genetic factors contributing to the development of multiple primary cancers, beyond known cancer syndro
Externí odkaz:
https://doaj.org/article/0d504290c7dd4cca98989c8be7a2c3c4
Autor:
Rebecca E. Graff, Taylor B. Cavazos, Khanh K. Thai, Linda Kachuri, Sara R. Rashkin, Joshua D. Hoffman, Stacey E. Alexeeff, Maruta Blatchins, Travis J. Meyers, Lancelote Leong, Caroline G. Tai, Nima C. Emami, Douglas A. Corley, Lawrence H. Kushi, Elad Ziv, Stephen K. Van Den Eeden, Eric Jorgenson, Thomas J. Hoffmann, Laurel A. Habel, John S. Witte, Lori C. Sakoda
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
While genetic loci shared between cancer types have been identified, cross-cancer relationships for polygenic risk scores have not been well studied. Here, the authors have developed polygenic risk scores for 16 cancers in two large cohorts and ident
Externí odkaz:
https://doaj.org/article/c8c7f06feddc43b4892e0628726c8ee8
Autor:
Linda Kachuri, Stephen S. Francis, Maike L. Morrison, George A. Wendt, Yohan Bossé, Taylor B. Cavazos, Sara R. Rashkin, Elad Ziv, John S. Witte
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-18 (2020)
Abstract Background Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the genetic mechanisms of immune response to viral infection provides insight into disease etiology and therapeutic o
Externí odkaz:
https://doaj.org/article/7936984e0ac04210a8fc9f30e8ea6ce0
Autor:
Sara R. Rashkin, Rebecca E. Graff, Linda Kachuri, Khanh K. Thai, Stacey E. Alexeeff, Maruta A. Blatchins, Taylor B. Cavazos, Douglas A. Corley, Nima C. Emami, Joshua D. Hoffman, Eric Jorgenson, Lawrence H. Kushi, Travis J. Meyers, Stephen K. Van Den Eeden, Elad Ziv, Laurel A. Habel, Thomas J. Hoffmann, Lori C. Sakoda, John S. Witte
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Pleiotropic loci and genome-wide genetic correlations have identified shared heritability across some types of cancers. Here, the authors perform genome-wide association studies and characterize pan-cancer heritability and pleiotropy in individuals o
Externí odkaz:
https://doaj.org/article/45eda6708b934235846a8a794af520d2
Autor:
Taylor B. Cavazos, John S. Witte
Publikováno v:
HGG Advances, Vol 2, Iss 1, Pp 100017- (2021)
Summary: The majority of polygenic risk scores (PRSs) have been developed and optimized in individuals of European ancestry and may have limited generalizability across other ancestral populations. Understanding aspects of PRSs that contribute to thi
Externí odkaz:
https://doaj.org/article/e370a3a2c4b94369853a6cbf8b2da28e
Autor:
Taylor B. Cavazos, Jeffrey Wang, Oluwadamilare I. Afolabi, Alice Huang, Dung Ngoc Lam, Seda Kilinc, Jieyang Wang, Lisa Fish, Xuan Zhao, Andy Pohl, Helen Li, Kimberly H. Chau, Patrick A. Arensdorf, Fereydoun Hormozdiari, Hani Goodarzi, Babak Alipanahi
Publikováno v:
Cancer Research. 83:P1-05
Background: Early detection of breast cancer is crucial for optimal patient outcomes but cannot always be accomplished based on symptoms or screening mammography. Biomarker-based screening could aid early detection of breast cancer by improving sensi
Autor:
John S. Witte, Stephen K. Van Den Eeden, Thomas J. Hoffmann, Neil Risch, Catherine Schaefer, Pui-Yan Kwok, Mark N. Kvale, Lori C. Sakoda, Eric Jorgenson, Nirupa R. Ghai, Chun R. Chao, Dilrini K. Ranatunga, Jun Shan, Laurel A. Habel, Joseph Presti, David Aaronson, Simon Wong, Eunice Wan, Linda Kachuri, Joel A. Mefford, Caroline G. Tai, Rebecca E. Graff, Clinton L. Cario, Sara R. Rashkin, Taylor B. Cavazos, Nima C. Emami
Figure S1-S6, Table S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3832c1cc5a2ef438ce0e17b1f933c0
https://doi.org/10.1158/0008-5472.22428541.v1
https://doi.org/10.1158/0008-5472.22428541.v1
Autor:
Wei Zheng, Rosalind A. Eeles, Christopher A. Haiman, John S. Witte, Zsofia Kote-Jarai, Matthew L. Freedman, Kathryn L. Penney, Bogdan Pasaniuc, Joshua A. Bauer, Xingyi Guo, Yingchang Lu, Xiao-Ou Shu, Jirong Long, Nima C. Emami, Taylor B. Cavazos, Qiuyin Cai, Jifeng Wang, Lang Wu
Genome-wide association study–identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain unknown. To discover novel pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b58ebf7b2e6dc29d053870e11671de2
https://doi.org/10.1158/0008-5472.c.6510960.v1
https://doi.org/10.1158/0008-5472.c.6510960.v1
Autor:
John S. Witte, Stephen K. Van Den Eeden, Thomas J. Hoffmann, Neil Risch, Catherine Schaefer, Pui-Yan Kwok, Mark N. Kvale, Lori C. Sakoda, Eric Jorgenson, Nirupa R. Ghai, Chun R. Chao, Dilrini K. Ranatunga, Jun Shan, Laurel A. Habel, Joseph Presti, David Aaronson, Simon Wong, Eunice Wan, Linda Kachuri, Joel A. Mefford, Caroline G. Tai, Rebecca E. Graff, Clinton L. Cario, Sara R. Rashkin, Taylor B. Cavazos, Nima C. Emami
To identify rare variants associated with prostate cancer susceptibility and better characterize the mechanisms and cumulative disease risk associated with common risk variants, we conducted an integrated study of prostate cancer genetic etiology in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39deb2175dd5fb54b8fc87beeb38bb7b
https://doi.org/10.1158/0008-5472.c.6513064
https://doi.org/10.1158/0008-5472.c.6513064
Abstract 5711: Blood-based early detection of non-small cell lung cancer using orphan noncoding RNAs
Autor:
Mehran Karimzadeh, Jeffrey Wang, Aiden Sababi, Oluwadamilare I. Afolabi, Dung Ngoc Lam, Alice Huang, Diana R. Corti, Kristle C. Garcia, Seda Kilinc, Xuan Zhao, Jieyang Wang, Taylor B. Cavazos, Patrick Arensdorf, Kimberly H. Chau, Helen Li, Hani Goodarzi, Lisa Fish, Fereydoun Hormozdiari, Babak Alipanahi
Publikováno v:
Cancer Research. 83:5711-5711
Background: Orphan non-coding RNAs (oncRNAs) are a novel category of small non-coding RNAs that are present in the tumor tissue and blood of people with cancer and largely absent in people without cancer. To examine the potential of using oncRNAs for