Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Taylor A Cole"'
Publikováno v:
Biophysical Reports, Vol 3, Iss 1, Pp 100098- (2023)
The thermodynamics of molecular recognition by proteins is a central determinant of complex biochemistry. For over a half-century, detailed cryogenic structures have provided deep insight into the energetic contributions to ligand binding by proteins
Externí odkaz:
https://doaj.org/article/69eae41ec89b401abf3ade8765988f6c
Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy
Autor:
Taylor R. Cole, Tatyana I. Igumenova
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Conserved homology 1 (C1) domains are peripheral zinc finger domains that are responsible for recruiting their host signaling proteins, including Protein Kinase C (PKC) isoenzymes, to diacylglycerol-containing lipid membranes. In this work, we invest
Externí odkaz:
https://doaj.org/article/2b876b3316f14cc489101842f4eff94b
Autor:
Azure B. Erskine, Janyla A. Seltzer, Jamilah A. Perkins, Arjun D Saini, Ginette A. Okoye, Marcus R Andrews, Taylor A Cole, Cassandra I F Collins, Chidubem A V Okeke, Faith C. Simmonds, Jessica D. Perry, John Kwagyan, Angel S. Byrd, William D. Shipman, Jane Otado
Publikováno v:
Dermatology. 238:180-184
Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy
Autor:
Tatyana I. Igumenova, Taylor R. Cole
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
Conserved homology 1 (C1) domains are peripheral zinc finger domains that are responsible for recruiting their host signaling proteins, including Protein Kinase C (PKC) isoenzymes, to diacylglycerol-containing lipid membranes. In this work, we invest
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote
Autor:
Samuel G. Erickson, Taylor R. Cole, Andreas Holzenburg, MinWoo Sung, Krystal A. Morales, Tatyana I. Igumenova
Publikováno v:
Biochemistry
Cd(2+) and Pb(2+) are xenobiotic heavy metal ions that use ionic mimicry to interfere with the cellular function of biomacromolecules. Using a combination of SAXS, electron microscopy, FRET, and solution NMR spectroscopy, we demonstrate that treatmen
Publikováno v:
The FASEB Journal. 34:1-1
Ca2+-dependent conserved-region 2 (C2) domains target their host signaling proteins to anionic membranes. The Ca2+-binding event is a prerequisite for membrane association. Here, we investigate multiscale metal-ion-dependent dynamics of the C2 domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b13e70c1d079e8eeabeeb0db7e72d5d
https://europepmc.org/articles/PMC5071625/
https://europepmc.org/articles/PMC5071625/
Publikováno v:
Biophysical Journal. 112:489a-490a
Protein Kinase C (PKC) isoenzymes are a family of kinases that control cell proliferation, migration, and apoptosis. The hallmark of PKC activation is their translocation to lipid membranes that occurs in response to Ca2+ and diacylglycerol. Previous
Autor:
Samuel G. Erickson, Andreas Holzenburg, Sachin Katti, P. John Hart, Min Woo Sung, Krystal A. Morales, David S. Cafiso, Tatyana I. Igumenova, Taylor R. Cole, Alexander B. Taylor, Sarah B. Nyenhuis
Publikováno v:
Biophysical Journal. 114:33a