Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Taylor, Merry"'
Autor:
Singer, Adam J., Taylor, Merry, LeBlanc, Deborah, Meyers, Kristen, Perez, Karol, Thode, Henry C., Jr., Pines, Jesse M.
Publikováno v:
In Journal of Emergency Medicine August 2018 55(2):172-178
Autor:
Selvi Pradeepan, Taylor Merry, Shelia Violette, Surinder S. Narula, Noriyuki Kawahata, Yihan Wang, Tomi K. Sawyer, David C. Dalgarno, Susan Adams, George P. Luke, Terence P. Keenan, Regine S. Bohacek, Wei Guan, Marie Rose van Schravendijk, Raji Sundaramoorthi, Jeffrey A. Keats, Mary K. Ram, Evelyn G. Corpuz, Chi B. Vu, Manfred Weigele, Chester A. Metcalf, Shuenn Liou, William C. Shakespeare
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3071-3074
The design of bone-targeted pyrido[2,3-d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using structure-based methods, we were able to rapidly incorporate bone binding components, which mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557b75ac7c90bb0fb12e38e1f0a1e1cc
https://doi.org/10.1016/s0960-894x(03)00649-8
https://doi.org/10.1016/s0960-894x(03)00649-8
Autor:
Shelia Violette, Noriyuki Kawahata, Catherine Bartlett, Tomi K. Sawyer, Regine S. Bohacek, Wei Guan, William C. Shakespeare, Xiaode Lu, Michael G. Yang, Yihan Wang, Jeremy Smith, Taylor Merry, Raji Sundaramoorthi, Charles J. Eyermann, George P. Luke, Daniel Johnson, Marcos Hatada, David C. Dalgarno
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2319-2323
The novel phosphotyrosine (pTyr) mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60 c-Src (Src) tyrosine kinase. A 2.2 A X-ray crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af601780cedf13e8fb805c0fb106afb3
https://doi.org/10.1016/s0960-894x(01)00446-2
https://doi.org/10.1016/s0960-894x(01)00446-2
Autor:
Regine S. Bohacek, Karina J. Macek, Manfred Weigele, Marcos Hatada, Tomi K. Sawyer, William C. Shakespeare, Chester A. Metcalf, David C. Dalgarno, Berkley A. Lynch, Surinder S. Narula, Taylor Merry, Shelia Violette, Virginia A. Jacobsen
Publikováno v:
Journal of Medicinal Chemistry. 44:660-663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b98587a3d11d3c4fde1d366bbe4bc3c
https://doi.org/10.1021/jm0002681
https://doi.org/10.1021/jm0002681
Autor:
Kara A. Loiacono, Ian A. MacNeil, Berkley A. Lynch, Taylor Merry, Chi B. Vu, Ukti Mani, Vaibhav Varkhedkar, John L. Buchanan, Dennis A. Holt, Selvaluxmi G. Pradeepan, Hilary R. Plake, Michael Yang, Evelyn G. Corpuz, Choi Lai Tiong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2359-2364
The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e24c3271625ce90015f47df8c67738d
https://doi.org/10.1016/s0960-894x(99)00389-3
https://doi.org/10.1016/s0960-894x(99)00389-3
Autor:
Taylor Merry, Selvi Pradeepan, Raji Sundaramoorthi, Virginia A. Jacobsen, Mayumi Uesugi, Vaibhav Varkhedkar, Chi B. Vu, Chester A. Metcalf, Jeremy Green, Dennis A. Holt, Edgardo Laborde, Karina J. Macek, Yinka Green
Publikováno v:
Tetrahedron Letters. 39:3435-3438
An efficient method for the preparation of protected phosphate ester-linked resins in high yield and purity is presented. Variation in tether length/functionality and substitution pattern of the phenol precursors, as well as mild deprotection conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa37765070d233783f49b9f5cf51fb75
https://doi.org/10.1016/s0040-4039(98)00586-3
https://doi.org/10.1016/s0040-4039(98)00586-3
Autor:
Daniel Johnson, Regine S. Bohacek, Michael Yang, Wei Guan, Charles J. Eyermann, Noriyuki Kawahata, Shelia Violette, George P. Luke, Tomi K. Sawyer, Raji Sundaramoorthi, Marcos Hatada, David C. Dalgarno, Yihan Wang, Catherine Bartlett, Taylor Merry, Xiaode Lu, Jeremy Smith, William C. Shakespeare
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcc85d365104665653d5568c376f78e0
https://doi.org/10.1007/0-306-46881-6_221
https://doi.org/10.1007/0-306-46881-6_221
Autor:
Chester A. Metcalf, Taylor Merry, Regine S. Bohacek, Charles J. Eyermann, Noriyuki Kawahata, Tomi K. Sawyer, Yihan Wang, Raji Sundaramoorthi, David C. Dalgarno, Michael G. Yang, Surinder S. Narula, William C. Shakespeare
Publikováno v:
Biopolymers. 71(6)
A series of novel nonpeptide inhibitors of the pp60c-Src (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x-ray structure of citrate complexed to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d407f768ac4e3c70f92d7dfb5c4b5b
https://pubmed.ncbi.nlm.nih.gov/14991680
https://pubmed.ncbi.nlm.nih.gov/14991680
Autor:
Chad Haraldson, Taylor Merry, Tomi K. Sawyer, Karin Stebbins, Marcos Hatada, Franklin Cerasoli, Surinder S. Narula, David C. Dalgarno, William C. Shakespeare, Marie Rose van Schravendijk, Jay Herson, Selvi Pradeepan, John Iuliucci, Manfred Weigele, Raji Sundaramoorthi, Xiaode Lu, Jeremy Smith, Mihai Azimioara, Susan Adams, Chester A. Metcalf, Shelia Violette, Chi B. Vu, Regine S. Bohacek, Michael Yang, Wei Guan, Catherine Bartlett
Targeted disruption of the pp60 src (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Herein we describe the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c5b835f12945cdcdbb7f6a31d14980
https://europepmc.org/articles/PMC16871/
https://europepmc.org/articles/PMC16871/
Autor:
Selvi Pradeepan, Chi B. Vu, Tomi K. Sawyer, Shelia Violette, van Schravendijk Mr, Ian A. MacNeil, Catherine Bartlett, Mary K. Ram, Botfield Mc, Charles J. Eyermann, Berkley A. Lynch, Taylor Merry, Evelyn G. Corpuz, Regine S. Bohacek
Publikováno v:
Journal of medicinal chemistry. 42(20)
A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target for immune suppression. These compounds typically are 200-400-fold more potent than the nati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d84c5760ebfcd16429d81250044b98
https://pubmed.ncbi.nlm.nih.gov/10514279
https://pubmed.ncbi.nlm.nih.gov/10514279