Výsledky vyhledávání - "Taylor, Merry"

A novel phosphotyrosine mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (cpp): exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain

Autor: Shelia Violette, Noriyuki Kawahata, Catherine Bartlett, Tomi K. Sawyer, Regine S. Bohacek, Wei Guan, William C. Shakespeare, Xiaode Lu, Michael G. Yang, Yihan Wang, Jeremy Smith, Taylor Merry, Raji Sundaramoorthi, Charles J. Eyermann, George P. Luke, Daniel Johnson, Marcos Hatada, David C. Dalgarno

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2319-2323

The novel phosphotyrosine (pTyr) mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide inhibitors of the SH2 domain of pp60 c-Src (Src) tyrosine kinase. A 2.2 A X-ray crystal st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af601780cedf13e8fb805c0fb106afb3
https://doi.org/10.1016/s0960-894x(01)00446-2

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Structure-activity relationships of a novel class of Src SH2 inhibitors

Autor: Kara A. Loiacono, Ian A. MacNeil, Berkley A. Lynch, Taylor Merry, Chi B. Vu, Ukti Mani, Vaibhav Varkhedkar, John L. Buchanan, Dennis A. Holt, Selvaluxmi G. Pradeepan, Hilary R. Plake, Michael Yang, Evelyn G. Corpuz, Choi Lai Tiong

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:2359-2364

The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e24c3271625ce90015f47df8c67738d
https://doi.org/10.1016/s0960-894x(99)00389-3

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Novel phosphate ester-linked resins: The solid-phase generation of phenyl phosphate-containing compounds for SH2 inhibition

Autor: Taylor Merry, Selvi Pradeepan, Raji Sundaramoorthi, Virginia A. Jacobsen, Mayumi Uesugi, Vaibhav Varkhedkar, Chi B. Vu, Chester A. Metcalf, Jeremy Green, Dennis A. Holt, Edgardo Laborde, Karina J. Macek, Yinka Green

Publikováno v: Tetrahedron Letters. 39:3435-3438

An efficient method for the preparation of protected phosphate ester-linked resins in high yield and purity is presented. Variation in tether length/functionality and substitution pattern of the phenol precursors, as well as mild deprotection conditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa37765070d233783f49b9f5cf51fb75
https://doi.org/10.1016/s0040-4039(98)00586-3

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Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain:phosphotyrosine mimetics exploiting multifunctional group replacement chemistry

Autor: Chester A. Metcalf, Taylor Merry, Regine S. Bohacek, Charles J. Eyermann, Noriyuki Kawahata, Tomi K. Sawyer, Yihan Wang, Raji Sundaramoorthi, David C. Dalgarno, Michael G. Yang, Surinder S. Narula, William C. Shakespeare

Publikováno v: Biopolymers. 71(6)

A series of novel nonpeptide inhibitors of the pp60c-Src (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate moiety of phosphotyrosine (pTyr). Relative to an x-ray structure of citrate complexed to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d407f768ac4e3c70f92d7dfb5c4b5b
https://pubmed.ncbi.nlm.nih.gov/14991680

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Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70

Autor: Selvi Pradeepan, Chi B. Vu, Tomi K. Sawyer, Shelia Violette, van Schravendijk Mr, Ian A. MacNeil, Catherine Bartlett, Mary K. Ram, Botfield Mc, Charles J. Eyermann, Berkley A. Lynch, Taylor Merry, Evelyn G. Corpuz, Regine S. Bohacek

Publikováno v: Journal of medicinal chemistry. 42(20)

A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target for immune suppression. These compounds typically are 200-400-fold more potent than the nati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d84c5760ebfcd16429d81250044b98
https://pubmed.ncbi.nlm.nih.gov/10514279

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