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pro vyhledávání: '"Tayler F.L. Wishart"'
Autor:
Tayler F.L. Wishart, Frank J. Lovicu
Publikováno v:
Progress in Retinal and Eye Research. 93:101118
Heparan sulfate proteoglycans (HSPGs) reside in most cells; on their surface, in the pericellular milieu and/or extracellular matrix. In the eye, HSPGs can orchestrate the activity of key signalling molecules found in the ocular environment that prom
Autor:
Frank J. Lovicu, Tayler F.L. Wishart
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The arrangement of lens cells is regulated by ocular growth factors. Although the effects of these inductive molecules on lens cell behavior (proliferation, survival, and fiber differentiation) are well-characterized, the precise mechanisms u
Publikováno v:
Experimental eye research. 210
Lens homeostasis and transparency are dependent on the function and intercellular communication of its epithelia. While the lens epithelium is uniquely equipped with functional repair systems to withstand reactive oxygen species (ROS)-mediated oxidat
Autor:
Malin Lundmark, Frank J. Lovicu, Daisy Y. Shu, Juanita Chui, Kevin Ng, Tayler F.L. Wishart, Mary Flokis
Publikováno v:
Experimental eye research. 206
Transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling play opposing roles in epithelial-mesenchymal transition (EMT) of lens epithelial cells, a cellular process integral to the pathogenesis of fibrotic cataract. We p
Publikováno v:
Experimental Eye Research. 192:107918
The reactive oxygen species (ROS) producing enzyme, NADPH oxidase 4 (Nox4), is upregulated in response to TGFβ in lens epithelial cells in vitro, and its selective inhibition was shown to block aspects of TGFβ-induced epithelial-mesenchymal transit
Publikováno v:
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 38(4)
Application of medicated honey (MH) to peritoneal dialysis (PD) catheter exit sites has been found to be as effective as intra-nasal mupirocin for preventing PD catheter-related infections (CRIs), but was associated with increased risk for CRIs in di