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Publikováno v:
Organic Letters. 23:6895-6899
Colibactin is a genotoxic hybrid polyketide-nonribosomal peptide that drives colorectal cancer initiation. While clinical data suggest colibactin genotoxicity in vivo is largely caused by the major DNA-cross-linking metabolite, the colibactin locus p
Autor:
Tayah Turocy, Jason M. Crawford
Publikováno v:
Cell Chemical Biology. 27:1329-1331
Chemotherapeutic treatments are frequently impeded by the development of multidrug resistance (MDR). In this issue of Cell Chemical Biology, Wang et al. (2020) identify the natural product verucopeptin as having therapeutic potential toward MDR cance