Enhanced production of taxadiene in Saccharomyces cerevisiae

Autor: Behnaz Nowrouzi, Rachel A. Li, Laura E. Walls, Leo d’Espaux, Koray Malcı, Lungang Liang, Nestor Jonguitud-Borrego, Albert I. Lerma-Escalera, Jose R. Morones-Ramirez, Jay D. Keasling, Leonardo Rios-Solis

Publikováno v: Microbial Cell Factories, Vol 19, Iss 1, Pp 1-12 (2020)

Abstract Background Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol®), remains limited despite growing global demands. Low yields of the critical taxadiene precursor remains a key bottleneck in microbial product

Externí odkaz: https://doaj.org/article/a87fb7aff08248b2a3922231dfcb72be

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Enhanced production of taxadiene in Saccharomyces cerevisiae

Autor: Lungang Liang, Behnaz Nowrouzi, Laura E. Walls, Albert Isaac Lerma-Escalera, Jay D. Keasling, Jose Ruben Morones-Ramirez, Nestor Jonguitud-Borrego, Rachel Li, Koray Malcı, Leo d'Espaux, Leonardo Rios-Solis

Publikováno v: Microbial Cell Factories, Vol 19, Iss 1, Pp 1-12 (2020)
Microbial Cell Factories
Microbial cell factories, vol 19, iss 1
Nowrouzi, B, Li, R A, Walls, L E, d 'Espaux, L, Malci, K, Liang, L, Jonguitud Borrego, N, Lerma-Escalera, A I, Morones-Ramirez, J R, Keasling, J D & Rios Solis, L 2020, ' Enhanced production of taxadiene in Saccharomyces cerevisiae ', Microbial Cell Factories, vol. 19, 200 . https://doi.org/10.1101/2020.06.08.139600, https://doi.org/10.1186/s12934-020-01458-2
Nowrouzi, B, Li, R A, Walls, L E, d’Espaux, L, Malcı, K, Liang, L, Jonguitud-Borrego, N, Lerma-Escalera, A I, Morones-Ramirez, J R, Keasling, J D & Rios-Solis, L 2020, ' Enhanced production of taxadiene in Saccharomyces cerevisiae ', Microbial Cell Factories, vol. 19, no. 1, 200 . https://doi.org/10.1186/s12934-020-01458-2

Background Cost-effective production of the highly effective anti-cancer drug, paclitaxel (Taxol®), remains limited despite growing global demands. Low yields of the critical taxadiene precursor remains a key bottleneck in microbial production. In t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2169e5b745cd0b854149be4c3d2912a6
http://link.springer.com/article/10.1186/s12934-020-01458-2

Purification and biochemical characterization of taxadiene synthase from bacillus koreensis and stenotrophomonas maltophilia

Autor: Mahmoud Sitohy, Yara Morsy, Ashraf S.A. El-Sayed, Ahmed A. Shindia, Maher Fathalla, Ashraf F. El-Baz, Amgad M. Rady, Basel Sitohy

Publikováno v: Scientia Pharmaceutica; Volume 89; Issue 4; Pages: 48
Scientia Pharmaceutica, Vol 89, Iss 48, p 48 (2021)

Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes the geranylgeranyl pyrophosphate into taxadiene. Attenuating Taxol productivity by fungi is the main challenge impeding its industrial application; it is possibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c47aa4dd775ea0f8d85a8df364c21b7
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190003

Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana

Autor: Kaibo Wang, Lei Yang, Yong Wang, Ishmael Mutanda, Jianhua Li, Jiawei Wang

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications

Production of the anticancer drug Taxol and its precursors in heterologous hosts is more sustainable than extraction from tissues of yew trees or chemical synthesis. Although attempts to engineer the Taxol pathway in microbes have made significant pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271389e2da66d2e99c0ee661793a67b0
https://doaj.org/article/8428c9211e514f2db08b62a0cc8920f5