Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tawnya E. Smith"'
Autor:
Victor V. Ozols, Murad Ali Khan, Michael P. Murphy, Jenny Beard, Sarah A. Sagi, Pritam Das, Sami L. Merit, Jason L. Eriksen, Rajashaker Kache, Abdul H. Fauq, Tawnya E. Smith, Thomas Kukar, Mark K. Dodson, Sascha Weggen, Todd E. Golde, Edward H. Koo, Thomas B. Ladd, Panos Z. Anastasiadis
Publikováno v:
Nature Medicine. 11:545-550
Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845ee8f1866fb3c2aad3d8734f299d7d
https://doi.org/10.1038/nm1235
https://doi.org/10.1038/nm1235
Autor:
Edward H. Koo, Sascha Weggen, Numa R. Marquez-Sterling, Claus U. Pietrzik, David E. Kang, Tawnya E. Smith, Rong Wang, Jason L. Eriksen, Michael P. Murphy, Kirk A. Findlay, Thomas Bulter, Pritam Das, Sarah A. Sagi, Todd E. Golde
Publikováno v:
Nature. 414:212-216
Epidemiological studies have documented a reduced prevalence of Alzheimer's disease among users of nonsteroidal anti-inflammatory drugs (NSAIDs). It has been proposed that NSAIDs exert their beneficial effects in part by reducing neurotoxic inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9285d228f7a4c57b3845a584b59a46
https://doi.org/10.1038/35102591
https://doi.org/10.1038/35102591
Autor:
Todd E. Golde, Michael P. Murphy, Tawnya E. Smith, Richard C. Wang, D C McLendon, Abdul H. Fauq, Kirk A. Findlay, Paul E. Fraser, H A Lookingbill, Patrick A. Lewis, Sacha N. Uljon
Publikováno v:
Journal of Biological Chemistry. 275:26277-26284
Presenilins (PSs) are polytopic membrane proteins that have been implicated as potential therapeutic targets in Alzheimer's disease because of their role in regulating the gamma-secretase cleavage that generates the amyloid beta protein (Abeta). It i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::301bd5a56eae036a30a2d3baddbf9416
https://doi.org/10.1074/jbc.m002812200
https://doi.org/10.1074/jbc.m002812200
Autor:
Jason L. Eriksen, Pritam Das, Edward H. Koo, Victor V. Ozols, Sascha Weggen, Daniel C. McLendon, Tawnya E. Smith, Kenton H. Zavitz, Kevin W. Jessing, Todd E. Golde, Sarah A. Sagi
Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer disease (AD). In this study, 20 commonly used NSAIDs, dapsone, and enantiomers of flurbiprofen were analyzed for their a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5350d1db7fbe82fac94d9a873974ae21
https://europepmc.org/articles/PMC166298/
https://europepmc.org/articles/PMC166298/
Autor:
Tawnya E. Smith, Abduli Fauq, Chewski Ziani-Cherif, Kirk A. Findlay, Daniel C. McLendon, Michael P. Murphy
Publikováno v:
Neurobiology of Aging. 21:180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d207e9db51b30b1f4c619e961ab1ea2
https://doi.org/10.1016/s0197-4580(00)82147-8
https://doi.org/10.1016/s0197-4580(00)82147-8