Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tawfeeg A. O. Najjar"'
Cardioprotective Effects of Subcutaneous Ebselen against Daunorubicin-Induced Cardiomyopathy in Rats
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 99:412-417
Daunorubicin is an anthracycline antitumour agent that can cause severe cardiomyopathy leading to a frequently fatal congestive heart failure. Although the exact molecular mechanisms of cardiotoxicity are not well established, oxidative mechanisms in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524e1657aea4bc6cf969e04a15d81b6e
https://doi.org/10.1111/j.1742-7843.2006.pto_523.x
https://doi.org/10.1111/j.1742-7843.2006.pto_523.x
Autor:
Sherif Y. Saad, Tawfeeg A. O. Najjar
Publikováno v:
Archives of Toxicology. 79:493-499
The aim of this study was to analyze the effect of streptozotocin (STZ)-induced diabetic state and the insulin-like acting, vanadyl sulphate (VS) on cyclosporine A (CyA) related nephrotoxicity in rats. Male Wistar rats were divided into six groups, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def52a62736cacf0426a776236fbcb77
https://doi.org/10.1007/s00204-005-0663-7
https://doi.org/10.1007/s00204-005-0663-7
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 18:78-86
The higher incidence of cardiotoxicity of doxorubicin (DOX)/paclitaxel (PTX) combination compared with DOX alone remains to be a major obstacle against effective chemotherapeutic treatment. We investigated the effect of sequence and time interval bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd039827231cafd00857613099ca87d
https://doi.org/10.1002/jbt.20012
https://doi.org/10.1002/jbt.20012
Publikováno v:
Chemotherapy. 48:309-315
Background: Nitric oxide (NO) has been shown to play a role in maintaining normal renal function. However, the role of NO in cisplatin (CDDP)-induced nephrotoxicity is still unclear. The aim of the present work was to examine the effect of the NO syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f72d626d866d87c5a2ab44cd1a6c21f
https://doi.org/10.1159/000069714
https://doi.org/10.1159/000069714
Publikováno v:
Pharmacological Research. 43:193-198
The effects of gemcitabine (dFdC) on the lipid peroxidation and kidney histopathology in the nephrotoxicity of an antitumour drug cisplatin (CDDP) were studied in rats. dFdC was administered intraperitoneally (i.p.) at single doses of 90 mgkg(-1) whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1822d09b0421acf43dc5f9ffa676262f
https://doi.org/10.1006/phrs.2000.0764
https://doi.org/10.1006/phrs.2000.0764
Autor:
Sherif Y. Saad, Tawfeeg A. O. Najjar
Publikováno v:
Chemotherapy. 47:128-135
Background: This study was designed to investigate the relationship between the attenuation of cisplatin (CDDP)-induced nephrotoxicity in experimental diabetic rabbits and the plasma pharmacokinetics of the free ultrafilterable and total plasma plati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe7057472f5defae2503219495f543d
https://doi.org/10.1159/000048512
https://doi.org/10.1159/000048512
Autor:
Hisham S. Abou-Auda, Nasser F. Al-Fawzan, Nausha M. Ghilzai, Tawfeeg A. O. Najjar, Khalil I. Al-Khamis, Badraddin M.H. Al-Hadiya
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 22:241-249
A highly sensitive, selective and reproducible reversed-phase high-performance liquid chromatographic method has been developed for the determination of nifedipine in human plasma with minimum sample preparation. The method is sensitive to 3 ng/ml in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e01f4a0f9ecfa3e1065843eefc6599f
https://doi.org/10.1016/s0731-7085(99)00258-7
https://doi.org/10.1016/s0731-7085(99)00258-7
Autor:
Tawfeeg A. O. Najjar
Publikováno v:
International Journal of Pharmaceutics. 131:67-71
The effect of cefoperazone (CPZ) on the pharmacokinetics of methotrexate (MTX) was studied in 10 rabbits. MTX was administered as a bolus dose of 2 mg kg −1 , followed by a constant infusion of 50 μg kg −1 min −1 for 120 min. A group of 5 rabb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0404829f98dc39f8b3a11424ff82c641
https://doi.org/10.1016/0378-5173(95)04359-4
https://doi.org/10.1016/0378-5173(95)04359-4
Autor:
P. Stravoravdi, Ayşe Özder, Konstantinos Charalabopoulos, I.Y. Lubenko, K.B. Lai, R.S.M. Wong, I.L.K. Wong, Mohammed H. Daba, F.Y. Lau, C.H. Chui, G. Zafiriou, Ammar C. Al-Rikabi, S.N. Vostrov, Michael Illauer, Hüsniye Yüksel, Y.Z. Zhao, I.T.N. Teo, Konstantinos Natsis, Tawfeeg A. O. Najjar, T.W.T. Leung, Rainer Weissenbacher, Yury A. Portnoy, Emine Küçükateş, K.M.S. Tsang, Bekir Kocazeybek, Serdar Kucukoglu, Cornelia B. Landersdorfer, D.A. Guo, W.Q. Tan, L.M.C. Chow, G. Cheng, Stephen H. Zinner, Andreas Skott, Alexander A. Firsov, Annette Hofmann, W.H. Lam, George N. Karachalios, J.C.O. Tang, A.S.C. Chan, Rüstem Olga, Martina Kinzig-Schippers, Fritz Sörgel, Sherif Y. Saad, A. Grekou, A. Barich
Publikováno v:
Chemotherapy. 48:325-327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e0b532cfc76dd6a9e49dc843c4d6d6e
https://doi.org/10.1159/000070470
https://doi.org/10.1159/000070470
Publikováno v:
International Journal of Pharmaceutics. 98:51-55
The effect of theophylline on the elimination of flumazenil during constant infusion of l mg/kg per h over 240 min was investigated in 10 rabbits. Theophylline was introduced as a single intravenous (i.v.) dose of 5 mg/kg (5 rabbits) and 15 mg/kg (5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::668a581f8fb32cb15f4719402d4f070d
https://doi.org/10.1016/0378-5173(93)90040-m
https://doi.org/10.1016/0378-5173(93)90040-m