Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tavis D. Steenbeke"'
Autor:
Sergei Radaev, Prateeti Khazanie, Anthony S. Fauci, Domenico Mavilio, Peter Schuck, Shyam Kottilil, Claudia Cicala, Donald Van Ryk, James Arthos, Marybeth Daucher, Ronald L. Rabin, Peter D. Sun, Eva Chung, Neil Gupta, Nina Censoplano, Catherine C. Cruz, Tavis D. Steenbeke, Margery A. Chaikin
Publikováno v:
Virology. 332:491-497
Natural killer (NK) cells play an important role in both innate and adaptive antiviral immune responses. The adaptive response typically requires that virus-specific antibodies decorate infected cells which then direct NK cell lysis through a CD16 me
Autor:
Joseph Sodroski, Tavis D. Steenbeke, Claudia Cicala, Shahzad Majeed, Wayne A. Hendrickson, Paul W. I. H. Parren, Peter D. Kwong, Dennis R. Burton, Michael Fung, James E. Robinson, Richard T. Wyatt, Miro Venturi, Michael L. Doyle, Stephanie A. Leavitt, Hermann Katinger, James Arthos, Ernesto Freire, Irwin Chaiken, Liping Wang, Donald Van Ryk, David J. Casper
Publikováno v:
Nature. 420:678-682
The ability of human immunodeficiency virus (HIV-1) to persist and cause AIDS is dependent on its avoidance of antibody-mediated neutralization. The virus elicits abundant, envelope-directed antibodies that have little neutralization capacity. This l
Autor:
Judith Manola, Daniela Rhone, Michael K. Axthelm, Joseph Sodroski, Tavis D. Steenbeke, Bijan Etemad-Moghadam, Paul Racz, Norman L. Letvin, John W. Fanton, Ying Sun, Rebecca Gelman, Klara Tenner-Racz
Publikováno v:
Vaccine. 20:1934-1937
The efficacy of candidate AIDS vaccines to mediate protection against viral infection and pathogenesis is evaluated, at a preclinical stage, in animal models. One model that is favored because the infecting virus is closely related to HIV-1 and becau
Autor:
Charles S. Dela Cruz, Daniel Nam, Margery A. Chaikin, Tae-Wook Chun, James Arthos, Peter Schuck, Tavis D. Steenbeke, Sara Selig, Anthony S. Fauci, Claudia Cicala, Prateeti Khazanie, Douglas B. Hanback, Donald Van Ryk
Publikováno v:
Journal of Biological Chemistry. 277:11456-11464
Drug toxicities associated with HAART lend urgency to the development of new anti-HIV therapies. Inhibition of viral replication at the entry stage of the viral life cycle is an attractive strategy because it prevents de novo infection. Soluble CD4 (
Autor:
Claudia Cicala, Anthony S. Fauci, James Arthos, Sara Selig, Prateeti Khazanie, Ronald L. Rabin, Elizabeth Machado, Hanumanth M. Ravindranath, Andrew A. White, Douglas B. Hanback, Donald Van Ryk, Meredith S. Hanback, Tavis D. Steenbeke
Publikováno v:
Virology. 292:98-106
We examined the role of CD4, CXCR4, and CCR5 in HIV envelope-mediated apoptosis by measuring the response of activated PBMCs to recombinant envelope proteins derived from CXCR4- and CCR5-utilizing viruses. Apoptosis of T cells was assessed by annexin
Autor:
Kristin Beaudry, Keith A. Reimann, Abie Craiu, Tavis D. Steenbeke, Michelle A. Lifton, Dan H. Barouch, Julie D. Frost, Norman L. Letvin, Marcelo J. Kuroda, Terry B. Strom, Christy E. Nickerson, Joern E. Schmitz, Xin Xiao Zheng
Publikováno v:
AIDS Research and Human Retroviruses. 17:873-886
The T cell-stimulatory cytokine interleukin 2 (IL-2) is being evaluated as a therapeutic in the clinical settings of HIV infection and cancer. However, the clinical utility of IL-2 may be mitigated by its short in vivo half-life, toxic effects, and h
Autor:
Terry B. Strom, Gwendolyn J. Heidecker, John W. Shiver, Christine E. Nickerson, Helen C. Perry, Sampa Santra, Hong Xie, Michelle A. Lifton, Xin Xiao Zheng, Carroll L. Crabbs, Dan H. Barouch, Georgia R. Krivulka, Carol I. Lord, Tavis D. Steenbeke, Julie D. Frost, David C. Montefiori, Marcelo J. Kuroda, Mary-Ellen Davies, Mark G. Lewis, Abie Craiu, Jörn E. Schmitz, Norman L. Letvin
Publikováno v:
Proceedings of the National Academy of Sciences. 97:4192-4197
The potential utility of plasmid DNA as an HIV-1 vaccination modality currently is an area of active investigation. However, recent studies have raised doubts as to whether plasmid DNA alone will elicit immune responses of sufficient magnitude to pro
Autor:
Carol I. Lord, Tavis D. Steenbeke, Andrew Watson, Keith A. Reimann, Gunilla B. Karlsson, Peter J. Dailey, Wenyu Lin, Robert A. Parker, Michael K. Axthelm
Publikováno v:
Virology. 256:15-21
To determine the role of viral burden in simian–human immunodeficiency virus (SHIV)-induced disease, cellular provirus and plasma viral RNA levels were measured after inoculation of rhesus monkeys with four different SHIVs. These SHIVs included SHI
Autor:
Dan H. Barouch, Sampa Santra, Tavis D. Steenbeke, Xin X. Zheng, Helen C. Perry, Mary-Ellen Davies, Daniel C. Freed, Abie Craiu, Terry B. Strom, John W. Shiver, Norman L. Letvin
Publikováno v:
The Journal of Immunology. 161:1875-1882
The use of cytokines has shown promise as an approach for amplifying vaccine-elicited immune responses, but the application of these immunomodulatory molecules in this setting has not been systematically explored. In this report we investigate the us
Autor:
James, Arthos, Claudia, Cicala, Tavis D, Steenbeke, Tae-Wook, Chun, Charles, Dela Cruz, Douglas B, Hanback, Prateeti, Khazanie, Daniel, Nam, Peter, Schuck, Sara M, Selig, Donald, Van Ryk, Margery A, Chaikin, Anthony S, Fauci
Publikováno v:
The Journal of biological chemistry. 277(13)
Drug toxicities associated with HAART lend urgency to the development of new anti-HIV therapies. Inhibition of viral replication at the entry stage of the viral life cycle is an attractive strategy because it prevents de novo infection. Soluble CD4 (