Výsledky vyhledávání - "Tavina Claiborne"

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Autor: Margaret R. Pancost, Yanyi Zhu, Andrew McRiner, Jonathan E. Grob, Peter Atadja, Lewis Whitehead, Tommasi Ruben A, Travis Stams, Markus Dobler, Ping Wang, Wenlin Shao, Branko Radetich, Brian Edward Vash, Ritesh Bhanudasji Tichkule, Anup Patnaik, Michael Shultz, Tavina Claiborne

Publikováno v: Bioorganicmedicinal chemistry. 19(15)

Herein we report the discovery of a family of novel yet simple, amino-acid derived class I HDAC inhibitors that demonstrate isoform selectivity via access to the internal acetate release channel. Isoform selectivity criteria is discussed on the basis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226f867c89420283d21bf81c6617c3dc
https://pubmed.ncbi.nlm.nih.gov/21723733

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