Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants

Autor: Miller, Justin B, Ward, Elizabeth, Staley, Lyndsay A, Stevens, Jeffrey, Teerlink, Craig C, Tavana, Justina P, Cloward, Matthew, Page, Madeline, Dayton, Louisa, Alzheimer's Disease Genetics Consortium, Cannon-Albright, Lisa A, Kauwe, John SK

BackgroundLongevity as a phenotype entails living longer than average and typically includes living without chronic age-related diseases. Recently, several common genetic components to longevity have been identified. This study aims to identify addit

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https://escholarship.org/uc/item/92s035b3

Analysis of high‐risk pedigrees identifies 11 candidate variants for Alzheimer's disease.

Autor: Teerlink, Craig C., Miller, Justin B., Vance, Elizabeth L., Staley, Lyndsay A., Stevens, Jeffrey, Tavana, Justina P., Cloward, Matthew E., Page, Madeline L., Dayton, Louisa, Cannon‐Albright, Lisa A., Kauwe, John S.K.

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Feb2022, Vol. 18 Issue 2, p307-317, 11p

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Analysis of high-risk pedigrees identifies 11 candidate variants for Alzheimer's disease.

Autor: Teerlink CC; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Miller JB; Department of Biomedical Informatics, University of Kentucky Sanders-Brown Center on Aging, Lexington, Kentucky, USA., Vance EL; Department of Biology, Brigham Young University, Provo, Utah, USA., Staley LA; Department of Biology, Brigham Young University, Provo, Utah, USA., Stevens J; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Tavana JP; Department of Biology, Brigham Young University, Provo, Utah, USA., Cloward ME; Department of Biology, Brigham Young University, Provo, Utah, USA., Page ML; Department of Biology, Brigham Young University, Provo, Utah, USA., Dayton L; Department of Biology, Brigham Young University, Provo, Utah, USA., Cannon-Albright LA; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.; George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah, USA.; Huntsman Cancer Institute, Salt Lake City, Utah, USA., Kauwe JSK; Department of Biology, Brigham Young University, Provo, Utah, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Feb; Vol. 18 (2), pp. 307-317. Date of Electronic Publication: 2021 Jun 20.