Thermodynamic profile of mutual subunit control in a heteromeric receptor

Autor: Eckhard Schulz, Michele Bonus, Christian Sattler, Thomas Zimmer, Melanie Wiegand, Ralf Schmauder, Klaus Benndorf, Nisa Kosmalla, Holger Gohlke, Taulant Kukaj, Thomas Eick, Gunter Ehrlich, Tina Schwabe, Jan L. Münch, Jana Schirmeyer, Sabine Hummert

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 118(30), e2100469118 (2021). doi:10.1073/pnas.2100469118

Significance Membrane receptors control innumerous essential functions of living cells and are proven drug targets for pharmacological interventions. Many receptors are composed of a number of subunits and contain multiple binding sites for ligands,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958ee041afd71a562ab3c4251498b6ca
http://europepmc.org/articles/PMC8325370

Action potentials in Xenopus oocytes triggered by blue light

Autor: Shiqiang Gao, Thomas Zimmer, Christian Vom Dahl, Dominic Feind, Christoph Müller, Georg Nagel, Taulant Kukaj, Christian Sattler, Florian Walther

Publikováno v: The Journal of General Physiology

Channelrhodopsin-2 is the key ion channel in optogenetics. Walther et al. demonstrate that coupling channelrhodopsin-2 to the β1 subunit of voltage-gated sodium channels allows action potentials to be triggered by blue-light illumination of Xenopus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2022e9091ba5afcaae8812e226da10aa
https://doi.org/10.1085/jgp.201912489