Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Taufiq Rahman"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Poly ADP-ribose polymerase 1 (PARP1) is an attractive therapeutic target for cancer treatment. Machine-learning scoring functions constitute a promising approach to discovering novel PARP1 inhibitors. Cutting-edge PARP1-specific machine-lear
Externí odkaz:
https://doaj.org/article/a02fc69f5f844477a791bb844350e043
Publikováno v:
ACS Omega, Vol 9, Iss 2, Pp 2250-2262 (2023)
Externí odkaz:
https://doaj.org/article/836a7ff49f1048288d319bbc61a1e2fb
Publikováno v:
Jurnal HAM, Vol 14, Iss 2, Pp 155-168 (2023)
This article focuses on the enjoyment of the right to work for workers with disabilities. This focus is driven by the fact that there are still many discriminatory practices for workers with disabilities in the workplace. This study identifies, for i
Externí odkaz:
https://doaj.org/article/d177cfad5bc04bdb9eef3d797b2ec0d9
Autor:
Venkat M. K. Vadlamani, Kavinda K. J. Gunasinghe, Xavier W. Chee, Taufiq Rahman, Matthew T. Harper
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD1) metabolizes extracellular ATP and ADP to AMP. AMP is subsequently metabolized by CD79 to adenosine. CD39 activity is therefore a key regulator of purinergic signalling in cancer
Externí odkaz:
https://doaj.org/article/0581af87244d40ae89108dfbb7344a87
Publikováno v:
Platelets, Vol 33, Iss 7, Pp 1090-1095 (2022)
Thrombin is a potent platelet activator, acting through proteinase-activated receptors −1 and −4 (PAR1 and PAR4). Of these, PAR-1 is activated more rapidly and by lower thrombin concentrations. Consequently, PAR-1 has been extensively investigate
Externí odkaz:
https://doaj.org/article/28e019c8c241410d81c7994c80d91efb
Publikováno v:
Jurnal Elkomika, Vol 11, Iss 3 (2023)
ABSTRAK Untuk memastikan bahwa kebutuhan masyarakat yang berkembang terpenuhi dan tingkat ketergantungan sistem cukup, sangat penting untuk mengelola dan memelihara sistem distribusi daya yang andal. Karena jarak transmisi yang jauh, tidak mungkin u
Externí odkaz:
https://doaj.org/article/1461fa8120cc47fa8ea41cedd08d1a69
Autor:
Yu Yuan, Dawid Jaślan, Taufiq Rahman, Stephen R. Bolsover, Vikas Arige, Larry E. Wagner, Carla Abrahamian, Rachel Tang, Marco Keller, Jonas Hartmann, Anna S. Rosato, Eva-Maria Weiden, Franz Bracher, David I. Yule, Christian Grimm, Sandip Patel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
TPC2 is a lysosomal ion channel permeable to both calcium and sodium ions. Here, the authors show that TPC2 can selectively increase its calcium permeability when simultaneously challenged by both its natural activators- NAADP and PI(3,5)P2.
Externí odkaz:
https://doaj.org/article/db6d7bc0a8014e758a1eca79b88380fb
Autor:
Zhu-Hong Li, Thayer P. King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A. Vella, Isabelle Coppens, Sandip Patel, Silvia N. J. Moreno
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Two-pore channels (TPCs) are cation channels that localize to acidic organelles to regulate Ca2+ dependent events. Here, Li et al. characterize a TPC from Toxoplasma gondii(TgTPC) that localizes to the apicoplast, is critical for maintaining its inte
Externí odkaz:
https://doaj.org/article/40af680df6674080819ee06c0c3a8c98
Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
Autor:
Rameen Shakur, Juan Pablo Ochoa, Alan J. Robinson, Abhishek Niroula, Aneesh Chandran, Taufiq Rahman, Mauno Vihinen, Lorenzo Monserrat
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden cardiac death
Externí odkaz:
https://doaj.org/article/d83b655e70d2430db526ecf35be2769f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7360 (2023)
Protein kinase p38γ is an attractive target against cancer because it plays a pivotal role in cancer cell proliferation by phosphorylating the retinoblastoma tumour suppressor protein. Therefore, inhibition of p38γ with active small molecules repre
Externí odkaz:
https://doaj.org/article/624cfb1db50147afa7ee4ab8974aa92e