Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress.

Autor: Melis N; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Rubera I; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Giraud S; INSERM U1313, IRMETIST, Université de Poitiers et CHU de Poitiers, 86000 Poitiers, France., Cougnon M; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Duranton C; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Poet M; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Jarretou G; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Thuillier R; INSERM U1313, IRMETIST, Université de Poitiers et CHU de Poitiers, 86000 Poitiers, France., Counillon L; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Hauet T; INSERM U1313, IRMETIST, Université de Poitiers et CHU de Poitiers, 86000 Poitiers, France., Pellerin L; INSERM U1313, IRMETIST, Université de Poitiers et CHU de Poitiers, 86000 Poitiers, France., Tauc M; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France., Pisani DF; Université Côte d'Azur, CNRS, LP2M, 06108 Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, 06103 Nice, France.

Publikováno v: Cells [Cells] 2023 Jan 25; Vol. 12 (3). Date of Electronic Publication: 2023 Jan 25.

Extracellular pH alkalinization by Cl^-/HCO^-3 exchanger is crucial for TASK2 activation by hypotonic shock in proximal cell lines from mouse kidney.

Autor: L'Hoste, S., Barriere, H., Belfodil, R., Rubera, I., Duranton, C., Tauc, M., Poujeol, C., Barhanin, J., Poujeol, P.

Publikováno v: American Journal of Physiology: Renal Physiology; Feb2007, Vol. 292, pF628-F638, 11p, 1 Diagram, 2 Charts, 9 Graphs

The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles.

Autor: Tauc M; LP2M, CNRS, Université Côte d'Azur, Nice, France. michel.tauc@univ-cotedazur.fr.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France. michel.tauc@univ-cotedazur.fr.; Laboratoire de Physiomédecine Moléculaire, UMR7370, Faculté de Médecine, CNRS, Université Côte d'Azur, 28 Avenue de Valombrose, 06107, Nice Cedex, France. michel.tauc@univ-cotedazur.fr., Cougnon M; LP2M, CNRS, Université Côte d'Azur, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France., Carcy R; Service de Réanimation Polyvalente et Service de Réanimation des Urgences Vitales, CHU Nice, Hôpital Pasteur 2, Nice, France., Melis N; Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892, USA., Hauet T; INSERM, IRTOMIT, CHU de Poitiers, Université de Poitiers, La Milétrie, Poitiers, France., Pellerin L; INSERM, IRTOMIT, CHU de Poitiers, Université de Poitiers, La Milétrie, Poitiers, France., Blondeau N; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France.; IPMC, CNRS, Université Côte d'Azur, Valbonne, France., Pisani DF; LP2M, CNRS, Université Côte d'Azur, Nice, France.; Laboratories of Excellence Ion Channel Science and Therapeutics, Nice, France.

Publikováno v: Cell & bioscience [Cell Biosci] 2021 Dec 24; Vol. 11 (1), pp. 219. Date of Electronic Publication: 2021 Dec 24.

Preventive GC7 reduces brain death-induce renal injuries in a preclinical porcine model

Autor: Giraud, S., Kerforne, T., Couturier, Philippine, Inal, S., Hannaert, P., Tauc, M., Hauet, T.

Publikováno v: Abstracts of the 16th Annual Congress of the French Speaking Society of Transplantation
16. Annual Congress of the French Speaking Society of Transplantation
16. Annual Congress of the French Speaking Society of Transplantation, Dec 2016, Liège, Belgium, Belgium. 29 p., ⟨10.1111/tri.12885⟩
Abstracts of the 16th Annual Congress of the French Speaking Society of Transplantation. Issue Supplement S1 (30), 2017; 16. Annual Congress of the French Speaking Society of Transplantation, Liège, Belgium, BEL, 2016-12-06-2016-12-09, 9-9

N1-guanyl-1,7-diaminoheptane (GC7), an inhibitor of eIF5A, exhibits anti-inflammatory features and promotes anoxic/ischemic tolerance. Thus, GC7 pretreatment could be useful in order to protect organs submitted to ischemia before transplantation in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8a9cc38b00c09c51fc5a5fc4197f4674
https://hal.archives-ouvertes.fr/hal-01603786

Targeted deletion of nicotinamide adenine dinucleotide phosphate oxidase 4 from proximal tubules is dispensable for diabetic kidney disease development.

Autor: Thallas-Bonke V; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia., Tan SM; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Lindblom RS; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Snelson M; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Granata C; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.; Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia., Jha JC; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Sourris KC; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Laskowski A; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Watson A; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Tauc M; Laboratoire de Physiomédecine Moléculaire, LP2M, UMR-CNRS 7370, Université Côte d'Azur, Nice, France., Rubera I; Laboratoire de Physiomédecine Moléculaire, LP2M, UMR-CNRS 7370, Université Côte d'Azur, Nice, France., Zheng G; Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Shah AM; King's College London British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine and Sciences, London, UK., Harris DCH; Centre for Transplantation and Renal Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia., Elbatreek MH; Department of Pharmacology and Personalised Medicine, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Kantharidis P; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Cooper ME; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia., Jandeleit-Dahm K; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.; German Diabetes Centre, Leibniz Centre for Diabetes Research, Heinrich Heine University, Duesseldorf, Germany., Coughlan MT; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.; Department of Diabetes, Central Clinical School, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia.

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2021 May 27; Vol. 36 (6), pp. 988-997.