Design, Synthesis, and Preliminary Evaluation of [ ⁶⁸ Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer's Disease Mouse Model.

Autor: Taubel JC; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Nelson NR; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Bansal A; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Curran GL; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Wang L; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States., Wang Z; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States., Berg HM; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Vernon CJ; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Min HK; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Larson NB; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota 55905, United States., DeGrado TR; Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Kandimalla KK; Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States., Lowe VJ; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States., Pandey MK; Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minnesota 55905, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2022 May 18; Vol. 33 (5), pp. 892-906. Date of Electronic Publication: 2022 Apr 14.