Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Tau Proteins/cerebrospinal fluid"'
Autor:
Anna-Lena Haas, Pauline Olm, Janine Utz, Eva-Maria Siegmann, Philipp Spitzer, Anna Florvaag, Manuel Alexander Schmidt, Arnd Doerfler, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler, Timo Jan Oberstein, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease (AD) is indicated by a decrease in amyloid beta 42 (Aβ42) level or the Aβ42/Aβ40 ratio, and by increased levels of Tau with phosphorylated threonine at position 181 (pTau181) in cerebrospinal fluid (CSF) years bef
Externí odkaz:
https://doaj.org/article/a0515777f9ec40f49d049a47a82ea07a
Autor:
Pocevičiūtė, Dovilė, Nuñez-Diaz, Cristina, Roth, Bodil, Janelidze, Shorena, Giannisis, Andreas, Hansson, Oskar, Wennström, Malin
Publikováno v:
Alzheimer's Research & Therapy, 14(1). BioMed Central
Background Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that peripheral inflammation m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef7c6cecafd46218690474660fdcf38
https://pure.knaw.nl/portal/en/publications/88552aa0-acd0-4d49-be93-9829850b842b
https://pure.knaw.nl/portal/en/publications/88552aa0-acd0-4d49-be93-9829850b842b
Autor:
Visser, Pieter Jelle, Reus, Lianne M., Gobom, Johan, Jansen, Iris E, Dicks, Ellen, van der Lee, Sven J., Tsolaki, Magda, Verhey, Frans R. J., Popp, Julius, Martinez-Lage, Pablo, Vandenberghe, Rik, Lleó, Alberto, Molinuevo, José Luís, Engelborghs, Sebastiaan, Freund-Levi, Yvonne, Froelich, Lutz, Sleegers, Kristel, Dobricic, Valerija, Lovestone, Simon, Streffer, Johannes, Vos, Stephanie J. B., Bos, Isabelle, Smit, August B., Blennow, Kaj, Scheltens, Philip, Teunissen, Charlotte E., Bertram, Lars, Zetterberg, Henrik, Tijms, Betty M., Universitat Autònoma de Barcelona
Publikováno v:
Molecular Neurodegeneration, 17(1):27. BioMed Central Ltd
ADNI 2022, ' Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease ', MOLECULAR NEURODEGENERATION, vol. 17, no. 1, 27, pp. 27 . https://doi.org/10.1186/s13024-022-00521-3
MOLECULAR NEURODEGENERATION, 17(1):27. BioMed Central
ADNI 2022, ' Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease ', Molecular Neurodegeneration, vol. 17, 27, pp. 1-16 . https://doi.org/10.1186/s13024-022-00521-3
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Neurodegeneration
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Molecular neurodegeneration
Molecular Neurodegeneration, 17:27, 1-16. BioMed Central Ltd.
ADNI 2022, ' Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease ', MOLECULAR NEURODEGENERATION, vol. 17, no. 1, 27, pp. 27 . https://doi.org/10.1186/s13024-022-00521-3
MOLECULAR NEURODEGENERATION, 17(1):27. BioMed Central
ADNI 2022, ' Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease ', Molecular Neurodegeneration, vol. 17, 27, pp. 1-16 . https://doi.org/10.1186/s13024-022-00521-3
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Neurodegeneration
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Molecular neurodegeneration
Molecular Neurodegeneration, 17:27, 1-16. BioMed Central Ltd.
Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be increased in very early disease stages, when n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67617b1877d53b5a013b85b7161592f
https://cris.maastrichtuniversity.nl/en/publications/047fa75c-b8d1-4081-b0d5-e5c9ea34b556
https://cris.maastrichtuniversity.nl/en/publications/047fa75c-b8d1-4081-b0d5-e5c9ea34b556
Akademický článek
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Akademický článek
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Autor:
Vermunt, L., Sikkes, S. A. M., van den Hout, A., Handels, R., Bos, I., van der Flier, W. M., Kern, S., Ousset, P. -J., Maruff, P., Skoog, I., Verhey, F. R. J., Freund-Levi, Y., Tsolaki, M., Wallin, A. K., Olde Rikkert, M., Soininen, H., Spiru, L., Zetterberg, H., Blennow, K., Scheltens, P., Muniz-Terrera, G., Visser, P. J., Vellas, B., Reynish, E., Ousset, P. J., Andrieu, S., Burns, A., Pasquier, F., Frisoni, G., Salmon, E., Michel, J. P., Zekry, D. S., Boada, M., Dartigues, J. F., Olde-Rikkert, M. G. M., Rigaud, A. S., Winblad, B., Malick, A., Sinclair, A., Frolich, L., Ribera, C., Touchon, J., Robert, P., Salva, A., Waldemar, G., Bullock, R., Rodriguez, G., Jones, R. W., Stiens, G., Stoppe, G., Eriksdotter Jonhagen, M., Cherubini, A., Lage, P. M., Gomez-Isla, T., Camus, V., Aguera-Morales, E., Lopez, F., Savy, S., Cantet, C., Coley, N.
Publikováno v:
Alzheimer Disease Neuroimaging Initiative, AIBL Research Group & ICTUS/DSA study groups 2019, ' Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype ', Alzheimer's and Dementia, vol. 15, no. 7, pp. 888-898 . https://doi.org/10.1016/j.jalz.2019.04.001
Alzheimer's & Dementia, 15(7), 888-898. Elsevier Science
Alzheimer's & Dementia, 15, 7, pp. 888-898
Alzheimer's & Dementia, 15, 888-898
Alzheimer's and Dementia, 15(7), 888-898. Elsevier
Alzheimer's and Dementia, 15(7), 888-898. Elsevier Inc.
Vermunt, L, Sikkes, S A M, van den Hout, A, Handels, R, Bos, I, van der Flier, W M, Kern, S, Ousset, P-J, Maruff, P, Skoog, I, Verhey, F R J, Freund-Levi, Y, Tsolaki, M, Wallin, Å K, Olde Rikkert, M, Soininen, H, Spiru, L, Zetterberg, H, Blennow, K, Scheltens, P, Muniz-Terrera, G, Visser, P J, AIBL Research Group & Alzheimer Disease Neuroimaging Initiative 2019, ' Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype ', Alzheimer's and Dementia, vol. 15, no. 7, pp. 888-898 . https://doi.org/10.1016/j.jalz.2019.04.001
Alzheimer's & Dementia, Vol. 15, No 7 (2019) pp. 888-898
Alzheimer's & Dementia, 15(7), 888-898. Elsevier Science
Alzheimer's & Dementia, 15, 7, pp. 888-898
Alzheimer's & Dementia, 15, 888-898
Alzheimer's and Dementia, 15(7), 888-898. Elsevier
Alzheimer's and Dementia, 15(7), 888-898. Elsevier Inc.
Vermunt, L, Sikkes, S A M, van den Hout, A, Handels, R, Bos, I, van der Flier, W M, Kern, S, Ousset, P-J, Maruff, P, Skoog, I, Verhey, F R J, Freund-Levi, Y, Tsolaki, M, Wallin, Å K, Olde Rikkert, M, Soininen, H, Spiru, L, Zetterberg, H, Blennow, K, Scheltens, P, Muniz-Terrera, G, Visser, P J, AIBL Research Group & Alzheimer Disease Neuroimaging Initiative 2019, ' Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype ', Alzheimer's and Dementia, vol. 15, no. 7, pp. 888-898 . https://doi.org/10.1016/j.jalz.2019.04.001
Alzheimer's & Dementia, Vol. 15, No 7 (2019) pp. 888-898
Introduction: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration.M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03928efd25674f60e863f36648f9fe0
https://doi.org/10.1016/j.jalz.2019.04.001
https://doi.org/10.1016/j.jalz.2019.04.001
Publikováno v:
Saunders, T S, Jenkins, N, Blennow, K, Ritchie, C & Muniz-Terrera, G 2022, ' Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS) ', EBioMedicine, vol. 83, 104241 . https://doi.org/10.1016/j.ebiom.2022.104241
BACKGROUND: Alzheimer's Disease, the leading cause of dementia, is over-represented in females. The apolipoprotein E (APOE)ε4 allele is the strongest genetic risk factor for late-onset AD and is associated with aberrant cerebrospinal fluid levels (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a02117831259a9608c3c6b23734dcfb
https://doi.org/10.1016/j.ebiom.2022.104241
https://doi.org/10.1016/j.ebiom.2022.104241
Autor:
Frans R.J. Verhey, Lieke L. Smits, Huiberdina L. Koek, Wiesje M. van der Flier, Peter Paul De Deyn, Geert Jan Biessels, Pauline Aalten, Janne M. Papma, Inez H.G.B. Ramakers, Coen D.A. Stehouwer, Marcel Olde-Rikkert, Stefan L.C. Geijselaers, Annemieke C. Heijboer, Charlotte E. Teunissen, Fransje E. Reesink
Publikováno v:
Journal of Alzheimer's Disease, 61, 1, pp. 309-320
Journal of Alzheimers Disease, 61(1), 309-320. IOS Press BV
Journal of Alzheimer’s Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease
Geijselaers, S L C, Aalten, P, Ramakers, I H G B, De Deyn, P P, Heijboer, A C, Koek, H L, Olderikkert, M G M, Papma, J M, Reesink, F E, Smits, L L, Stehouwer, C D A, Teunissen, C E, Verhey, F R J, Van Der Flier, W M & Biessels, G J 2017, ' Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 309-320 . https://doi.org/10.3233/JAD-170522
Journal of Alzheimer's Disease, 61(1), 309. IOS Press
Journal of Alzheimer's Disease, 61, 309-320
Journal of Alzheimers Disease, 61(1), 309-320. IOS Press BV
Journal of Alzheimer’s Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease
Geijselaers, S L C, Aalten, P, Ramakers, I H G B, De Deyn, P P, Heijboer, A C, Koek, H L, Olderikkert, M G M, Papma, J M, Reesink, F E, Smits, L L, Stehouwer, C D A, Teunissen, C E, Verhey, F R J, Van Der Flier, W M & Biessels, G J 2017, ' Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 309-320 . https://doi.org/10.3233/JAD-170522
Journal of Alzheimer's Disease, 61(1), 309. IOS Press
Journal of Alzheimer's Disease, 61, 309-320
BACKGROUND: Abnormal insulin signaling in the brain has been linked to Alzheimer's disease (AD).OBJECTIVE: To evaluate whether cerebrospinal fluid (CSF) insulin levels are associated with cognitive performance and CSF amyloid-β and Tau. Additionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c053091c515e8ab1432707f2b80688e
https://doi.org/10.3233/jad-170522
https://doi.org/10.3233/jad-170522
Autor:
Aikaterini Oikonomidi, John Corthésy, Jérôme Wojcik, Gene L. Bowman, Hugues Henry, Antonio Núñez Galindo, Loïc Dayon, Ornella Cominetti, Julius Popp, Eugenia Migliavacca
Publikováno v:
Journal of Alzheimer's Disease, Vol. 60, No 4 (2017) pp. 1641-1652
Journal of Alzheimer's disease, vol. 60, no. 4, pp. 1641-1652
Journal of Alzheimer's disease, vol. 60, no. 4, pp. 1641-1652
Cerebrospinal fluid (CSF) biomarkers of the beta-amyloid and microtubule associated protein tau metabolism have proven the capacity to improve classification of subjects developing Alzheimer's disease (AD). The blood plasma proteome was characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a966e22661d220d7dba459211a2c04
https://doi.org/10.3233/jad-170426
https://doi.org/10.3233/jad-170426
Publikováno v:
Journal of psychiatric research
Journal of Psychiatric Research, Vol. 90 (2017) pp. 12-20
Journal of psychiatric research, vol. 90, pp. 12-20
Journal of Psychiatric Research, Vol. 90 (2017) pp. 12-20
Journal of psychiatric research, vol. 90, pp. 12-20
Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab99e507b7fb0f90d86f4bce899907
https://doi.org/10.1016/j.jpsychires.2016.12.024
https://doi.org/10.1016/j.jpsychires.2016.12.024