Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Tau Benned-Jensen"'
Autor:
Maja L. Hansen, Malene Ambjørn, Mikkel N. Harndahl, Tau Benned-Jensen, Karina Fog, Kaare Bjerregaard-Andersen, Florence Sotty
Publikováno v:
Cells, Vol 13, Iss 3, p 253 (2024)
Protein aggregation is a predominant feature of many neurodegenerative diseases, including synucleinopathies, which are characterized by cellular inclusions containing α-Synuclein (αSyn) phosphorylated at serine 129 (pSer129). In the present study,
Externí odkaz:
https://doaj.org/article/1f73d3d8dfcd4f2d93d98d8e2b676757
Autor:
Astrid S. Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjortø, Sara Rankin, Jon Våbenø, Mette M. Rosenkilde
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally p
Externí odkaz:
https://doaj.org/article/d920693ad8d842c78b29bd1b15141947
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing. While the
Externí odkaz:
https://doaj.org/article/c0b73440723e47138f8146c02754df1e
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24644 (2011)
BackgroundThe melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60
Externí odkaz:
https://doaj.org/article/dd39398976824e9baf73414537ea5c3f
Autor:
Viktoria M. S. Kjær, Viktorija Daugvilaite, Tomasz M. Stepniewski, Christian M. Madsen, Astrid S. Jørgensen, Kaustubh R. Bhuskute, Asuka Inoue, Trond Ulven, Tau Benned-Jensen, Siv A. Hjorth, Gertrud M. Hjortø, Ee Von Moo, Jana Selent, Mette M. Rosenkilde
Publikováno v:
Science Signaling. 16
The chemotactic G protein–coupled receptor GPR183 and its most potent endogenous oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) are important for immune cell positioning in secondary lymphoid tissues. This receptor-ligand pair is associa
Autor:
Sara M. Rankin, Viktorija Daugvilaite, Katia De Filippo, Goda Juzenaite, Astrid Sissel Jørgensen, Mette M. Rosenkilde, Maša Mavri, Christian Berg, Tau Benned-Jensen, Gertrud Malene Hjortø, Jon Våbenø
Publikováno v:
Communications Biology
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc85e58203949fdd2febe45ee002aba4
http://hdl.handle.net/10044/1/88841
http://hdl.handle.net/10044/1/88841
Autor:
Mario Rottländer, Morten Grupe, Vibeke Nielsen, Anette Graven Sams, Anne-Marie Jacobsen, Henrik Sindal Jensen, Morten Grunnet, Jesper F. Bastlund, Kristen Frederiksen, Tau Benned-Jensen, Lasse Skibsbye, Bo Hjorth Bentzen
Publikováno v:
European journal of pharmacology. 887
Activation of the voltage-gated Kv7 channels holds therapeutic promise in several neurological and psychiatric disorders, including epilepsy, schizophrenia, and depression. Here, we present a pharmacological characterization of Lu AA41178, a novel, p
Publikováno v:
Hefting, L L, D'Este, E, Arvedsen, E, Benned-Jensen, T & Rasmussen, H B 2020, ' Multiple Domains in the Kv7.3 C-Terminus Can Regulate Localization to the Axon Initial Segment ', Frontiers in Cellular Neuroscience, vol. 14, 10 . https://doi.org/10.3389/fncel.2020.00010
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 14 (2020)
The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a42b67e84ab1a0805af403523eb3f93
https://curis.ku.dk/portal/da/publications/multiple-domains-in-the-kv73-cterminus-can-regulate-localization-to-the-axon-initial-segment(5c76eed2-08c0-45e2-8ae7-55c0693c49cf).html
https://curis.ku.dk/portal/da/publications/multiple-domains-in-the-kv73-cterminus-can-regulate-localization-to-the-axon-initial-segment(5c76eed2-08c0-45e2-8ae7-55c0693c49cf).html
Autor:
Mette M. Rosenkilde, Clara Castello Echeverria, Andreas W. Sailer, Michael Lückmann, Viktorija Daugvilaite, Tau Benned-Jensen, Christian M. Madsen, Thomas M. Frimurer
Publikováno v:
British Journal of Pharmacology. 174:2031-2042
Background and Purpose The GPCR Epstein–Barr virus-induced gene 2 (EBI2, also known as GPR183) is activated by oxysterols and plays a pivotal role in the regulation of B cell migration during immune responses. While the molecular basis of agonist b
Autor:
Hongsheng Wang, Line Barington, Kristine Niss Arfelt, Allan Randrup Thomsen, Maria Rosaria Bassi, Mette M. Rosenkilde, Viktorija Daugvilaite, Thue W. Schwartz, Peter Johannes Holst, Alexander L. Kovalchuk, Tau Benned-Jensen, Kristoffer L. Egerod, Jan Pravsgaard Christensen, Katja Spiess, Herbert C. Morse, Valentina Kubale
Publikováno v:
Blood. 129:866-878
Human and mouse chronic lymphocytic leukemia (CLL) develops from CD5+ B cells that in mice and macaques are known to define the distinct B1a B-cell lineage. B1a cells are characterized by lack of germinal center (GC) development, and the B1a cell pop