Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model

Autor: Hongchang Gao, Liangcai Zhao, Qingqing Xu, Junjie Yan, Yafei Zheng, Hangying Xu, Chen Li, Qiaoying Jiang, Hong Zheng

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 2063-2074 (2020)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • Sex-specific metabolic differences occur in all brain regions of mice. • The hippocampal metabolism is more susceptible to T1D. • Metabolic disorders start at the cortex and hippocampus in female T1D mice. �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f4f182a76ce782a14533b123602dc5
http://www.sciencedirect.com/science/article/pii/S2001037020303512

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes

Autor: Shanlin Fu, Luke Carroll, Clare L. Hawkins, David I. Pattison, Michael J. Davies, Carl H. Schiesser

Publikováno v: Redox Biology, Vol 12, Iss, Pp 872-882 (2017)
Carroll, L, Pattison, D I, Fu, S, Schiesser, C H, Davies, M J & Hawkins, C L 2017, ' Catalytic oxidant scavenging by selenium-containing compounds : Reduction of selenoxides and N-chloramines by thiols and redox enzymes ', Redox Biology, vol. 12, pp. 872-882 . https://doi.org/10.1016/j.redox.2017.04.023
Redox Biology

Myeloperoxidase produces strong oxidants during the immune response to destroy invading pathogens. However, these oxidants can also cause tissue damage, which contributes to the development of numerous inflammatory diseases. Selenium containing compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5e5218fd8874c2ffff8165ab4d70e2
http://www.sciencedirect.com/science/article/pii/S2213231717302136

Abnormal brain oxygen homeostasis in an animal model of liver disease.

Autor: Hadjihambi A; UCL Institute for Liver and Digestive Health, Division of Medicine, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, UK.; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.; The Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK., Cudalbu C; CIBM Center for Biomedical Imaging, Lausanne, Switzerland.; Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Pierzchala K; CIBM Center for Biomedical Imaging, Lausanne, Switzerland.; Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.; Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Simicic D; CIBM Center for Biomedical Imaging, Lausanne, Switzerland.; Animal Imaging and Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Donnelly C; Institute of Sports Science and Department of Physiology, University of Lausanne, Lausanne, Switzerland., Konstantinou C; The Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, UK.; Faculty of Life Sciences and Medicine, King's College London, London, UK., Davies N; UCL Institute for Liver and Digestive Health, Division of Medicine, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, UK., Habtesion A; UCL Institute for Liver and Digestive Health, Division of Medicine, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, UK., Gourine AV; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK., Jalan R; UCL Institute for Liver and Digestive Health, Division of Medicine, UCL Medical School, Royal Free Hospital, Rowland Hill Street, London, UK.; European Foundation for the Study of Chronic Liver Failure., Hosford PS; Centre for Cardiovascular and Metabolic Neuroscience, Neuroscience, Physiology and Pharmacology, University College London, London, UK.; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, London, UK.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2022 May 24; Vol. 4 (8), pp. 100509. Date of Electronic Publication: 2022 May 24 (Print Publication: 2022).

Obstructive sleep apnea is associated with altered midbrain chemical concentrations.

Autor: Macey PM; School of Nursing, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States; Brain Research Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States. Electronic address: pmacey@ucla.edu., Sarma MK; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States., Prasad JP; School of Nursing, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States., Ogren JA; Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States., Aysola R; Department of Medicine (Division of Pulmonary and Critical Care), David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States., Harper RM; Brain Research Institute, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States; Department of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States., Thomas MA; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, United States.

Publikováno v: Neuroscience [Neuroscience] 2017 Nov 05; Vol. 363, pp. 76-86. Date of Electronic Publication: 2017 Sep 08.