Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tatyana S. Khlebnicova"'
Autor:
Veronica G. Zinovich, Tatyana S. Khlebnicova, Yu. A. Piven, Alexander V. Baranovsky, R. E. Trifonov, Fedor A. Lakhvich
Publikováno v:
Russian Journal of General Chemistry. 91:1438-1443
2-(Tetrazolylacetyl)cyclohexane-1,3-diones were synthesized via C-acylation of cyclohexane-1,3-diones with tetrazolylacetic acids in the presence of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N,N-dimethylaminopyridine in acetonit
Autor:
Tatyana S. Khlebnicova, I. V. Sorokina, Yuri A. Piven, Tatyana G. Tolstikova, Dmitry S. Baev, Fedor A. Lakhvich, Tatiana S. Frolova
Publikováno v:
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Background: Prevention and treatment of chronic inflammatory diseases require effective and low-toxic medicines. Molecular hybridization is an effective strategy to enhance the biological activity of new compounds. Triterpenoid scaffolds are in the f
Autor:
Alexander E. Sorochinsky, Yu. A. Piven, Igor I. Gerus, Fedor A. Lakhvich, Tatyana S. Khlebnicova
Publikováno v:
Doklady of the National Academy of Sciences of Belarus. 63:716-720
On the example of synthesis of 4-acetylamino-3-fluoroalkyl(aryl)-4,5,6,7-tetrahydro-1,2-benzisoxazoles, the effective approach to a synthesis of novel 4-acylamino-4,5,6,7-tetrahydro-1,2-benzisoxazoles is proposed. 3-Fluoroalkyl(aryl)- 6,7-dihydro-1,2
Autor:
Yuri A. Piven, Veronica G. Zinovich, Tatyana S. Khlebnicova, Margarita A. Yastrebova, Anton E. Matous, Danila V. Sorokin, Alexander M. Scherbakov, Yuri Yu. Shchegolev, Fedor A. Lakhvich
Publikováno v:
Organicbiomolecular chemistry. 19(47)
Effective method of synthesis of 8-aryl-4,5-dihydrothiazolo[4',5':3,4]benzo[1,2-c]isoxazol-2-amines was developed. The method includes α-keto bromination of 3-aryl-6,7-dihydrobenzo[c]isoxazol-4(5H)-ones followed by condensation of obtained bromo der
Autor:
Veronica G. Zinovich, Fedor A. Lakhvich, Tatyana S. Khlebnicova, Alexander V. Baranovsky, Victor V. Tatarskiy, Margarita A. Yastrebova, Alexander M. Scherbakov, Yuri A. Piven, Alvina I. Khamidullina, Julia A. Rusanova
Publikováno v:
Bioorganic & Medicinal Chemistry. 53:116521
Novel O-acylated (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-one oximes were designed as potential HSP90 inhibitors. A series of the compounds was synthesized by oximation of (E)-3-aryl-6,7-dihydrobenzisoxazol-4(5H)-ones followed by O-acylation with acy
Autor:
Veronica G. Isakova, Igor I. Gerus, Fedor A. Lakhvich, Alexander E. Sorochinsky, Tatyana S. Khlebnicova, Alexander V. Baranovsky, Yurii A. Piven
Publikováno v:
Journal of Heterocyclic Chemistry. 55:1791-1797
Autor:
Olga A. Balabon, Tatyana S. Khlebnicova, Elena N. Shaitanova, Igor I. Gerus, Antonina N. Rybakova, Fedor A. Lakhvich
Publikováno v:
Journal of Fluorine Chemistry. 252:109905
The synthesis of a series of polyfluoromethyl-substituted pyrimidines and pyrazoles bearing potential for further functionalization of the hydroxymethyl group prepared from the fluoroalkyl-containing enones with isothioureas, amidine and hydrazines,
Autor:
Fedor A. Lakhvich, Māris Turks, Irisa Rāviņa, Tatyana S. Khlebnicova, Viktors Kumpiņš, Inese Mieriņa, Svetlana V. Shishkina, Daina Zicāne, Alexander V. Baranovsky, Zenta Tetere, Inese Rijkure, Yuri A. Piven, Uldis Peipiņš
Publikováno v:
Steroids. 117:77-89
An efficient protocol for the synthesis of novel lupane triterpenoid-indazolone hybrids with oxime ester linkage has been developed from naturally accessible precursor betulin. For the first time a series of betulonic acid-indazolone hybrids have bee
Autor:
I. V. Sorokina, Fedor A. Lakhvich, Yuri A. Piven, Tatyana S. Khlebnicova, Tatyana G. Tolstikova, Alexander V. Baranovsky
Publikováno v:
Steroids. 147
A series of novel fluorine-containing lupane triterpenoid acid derivatives with fluoroaromatic amide moieties at the C-28 position (1–8) or with 2-(fluoroacyl)cyclopentane-1,3-dione fragments at the C-3 position (9–18) of lupane skeleton was synt
Autor:
Fedor A. Lakhvich, Māris Turks, Kirils Gorovojs, Inta Strakova, Sergey Belyakov, Tatyana S. Khlebnicova, Yuri A. Piven
Publikováno v:
Tetrahedron. 68:6131-6140
A new route toward 4-acylamino- and 4-amino-substituted tetrahydroindazoles is disclosed. The title compounds are obtained in good to excellent yields in the Ritter reaction between 4-hydroxy-tetrahydroindazoles and various nitriles. The reactivity o