Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tatyana M, Svitkina"'
Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity
Autor:
Eoin McEvoy, Tal Sneh, Emad Moeendarbary, Yousef Javanmardi, Nadia Efimova, Changsong Yang, Gloria E. Marino-Bravante, Xingyu Chen, Jorge Escribano, Fabian Spill, José Manuel Garcia-Aznar, Ashani T. Weeraratna, Tatyana M. Svitkina, Roger D. Kamm, Vivek B. Shenoy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown,
Externí odkaz:
https://doaj.org/article/671f9aee7e3c4eecaf25244cfd1b1fc2
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury
Autor:
Barbara Calabrese, Steven L. Jones, Yoko Shiraishi-Yamaguchi, Michael Lingelbach, Uri Manor, Tatyana M. Svitkina, Henry N. Higgs, Andy Y. Shih, Shelley Halpain
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Post injury cytoskeletal modifications in neurons are not fully understood. Here the authors describe a pro-survival actin cytoskeletal reorganization in neurons triggered during a model of ischemic stroke.
Externí odkaz:
https://doaj.org/article/e90bdbb4354e4126b7538ddf3eccdbce
Autor:
Aleksandra S. Chikina, Anna O. Zholudeva, Maria E. Lomakina, Igor I. Kireev, Alexander A. Dayal, Alexander A. Minin, Mathieu Maurin, Tatyana M. Svitkina, Antonina Y. Alexandrova
Publikováno v:
Cells, Vol 13, Iss 1, p 105 (2024)
The formation of specific cellular protrusions, plasma membrane blebs, underlies the amoeboid mode of cell motility, which is characteristic for free-living amoebae and leukocytes, and can also be adopted by stem and tumor cells to bypass unfavorable
Externí odkaz:
https://doaj.org/article/b5bc7033d81c4f7792df5472e0b5a111
Autor:
Lei Guan, Bin Wu, Ting Li, Lynn A. Beer, Gaurav Sharma, Mingyue Li, Chin Nien Lee, Shujing Liu, Changsong Yang, Lili Huang, Dennie T. Frederick, Genevieve M. Boland, Guangcan Shao, Tatyana M. Svitkina, Kathy Q. Cai, Fangping Chen, Meng-Qiu Dong, Gordon B. Mills, Lynn M. Schuchter, Giorgos C. Karakousis, Tara C. Mitchell, Keith T. Flaherty, David W. Speicher, Youhai H. Chen, Meenhard Herlyn, Ravi K. Amaravadi, Xiaowei Xu, Wei Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Lack of CD8+ T-cell infiltration into solid tumors is associated with poor responsiveness to immune checkpoint therapy (ICT). Here, the authors show that blocking the phosphorylation of HRS to reduce the induction of immunosuppressive exosomes promot
Externí odkaz:
https://doaj.org/article/718e304323ab40bb82fc54fc7895e125
Autor:
Xingyuan Fang, Tatyana M. Svitkina
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 3, Pp 151228- (2022)
Adenomatous Polyposis Coli (APC) protein is mostly known as a tumor suppressor that regulates Wnt signaling, but is also an important cytoskeletal protein. Mutations in the APC gene are linked to colorectal cancer and various neurological disorders a
Externí odkaz:
https://doaj.org/article/4169a48eae85457782c9d2ae31cff330
Autor:
Damien Garbett, Anjali Bisaria, Changsong Yang, Dannielle G. McCarthy, Arnold Hayer, W. E. Moerner, Tatyana M. Svitkina, Tobias Meyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extra
Externí odkaz:
https://doaj.org/article/59bc2c586f4e4738a09ac0f4b0640fca
Autor:
Sohaib Khalid Hashmi, Vasia Barka, Changsong Yang, Sabine Schneider, Tatyana M. Svitkina, Robert O. Heuckeroth
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
Actin γ 2, smooth muscle (ACTG2) R257C mutation is the most common genetic cause of visceral myopathy. Individuals with ACTG2 mutations endure prolonged hospitalizations and surgical interventions, become dependent on intravenous nutrition and bladd
Externí odkaz:
https://doaj.org/article/7c379ba04e0a48558f216012eb89e19e
Autor:
Tatyana M. Svitkina
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29654115d28a2248a486ace79cb05862
https://doi.org/10.1016/b978-0-12-821618-7.00087-0
https://doi.org/10.1016/b978-0-12-821618-7.00087-0
Autor:
Konstantinos Nakos, Md Noor A. Alam, Megan R. Radler, Ilona A. Kesisova, Changsong Yang, Joshua Okletey, Meagan R. Tomasso, Shae B. Padrick, Tatyana M. Svitkina, Elias T. Spiliotis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(50)
Cellular morphogenesis and processes such as cell division and migration require the coordination of the microtubule and actin cytoskeletons. Microtubule–actin crosstalk is poorly understood and largely regarded as the capture and regulation of mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ace4b386dbad307ec006893f45a2ca0
https://pubmed.ncbi.nlm.nih.gov/36475946
https://pubmed.ncbi.nlm.nih.gov/36475946
Autor:
Steven L. Jones, Tatyana M. Svitkina
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
The axon initial segment (AIS) is a specialized structure in neurons that resides in between axonal and somatodendritic domains. The localization of the AIS in neurons is ideal for its two major functions: it serves as the site of action potential fi
Externí odkaz:
https://doaj.org/article/e5181c02da9145ffa96ddf4b6bf0f65c