Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tatyana Ivanova-Nikolova"'
Autor:
Yacob Gomez-Llorente, José L. Chávez, Edgar Leal-Pinto, Qiong-Yao Tang, Iban Ubarretxena-Belandia, Rahul Mahajan, Zhe Zhang, Diomedes E. Logothetis, Lia Baki, Shobana Sundaram, Tatyana Ivanova-Nikolova
Publikováno v:
Journal of Biological Chemistry. 285:39790-39800
Kir3 channels control heart rate and neuronal excitability through GTP-binding (G) protein and phosphoinositide signaling pathways. These channels were the first characterized effectors of the βγ subunits of G proteins. Because we currently lack st
Autor:
Iban Ubarretxena-Belandia, Zhe Zhang, Rahul Mahajan, Qiong-Yao Tang, Shobana Sundaram, José L. Chávez, Edgar Leal-Pinto, Lia Baki, Yacob Gomez-Llorente, Tatyana Ivanova-Nikolova, Diomedes E. Logothetis
Publikováno v:
Biophysical Journal. 100:430a
Functional reconstitution of the purified chimeric Kir3.1 channel constituting the cytosolic domain of mammalian Kir3.1 and the transmembrane region of a prokaryotic KirBac1.3 was achieved in lipid bilayers by addition of PIP2 from the intracellular
Publikováno v:
Biophysical Journal. 96:463a
G-protein-gated inwardly rectifying K+ (GIRK) channels play a key role in the regulation of beat to beat variability of the heart (Wickman et al., 1998), yet the mechanisms that control this variability are not well understood. We hypothesized that d