Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Tatyana I. Igumenova"'
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists
Autor:
Sachin S. Katti, Inna V. Krieger, Jihyae Ann, Jeewoo Lee, James C. Sacchettini, Tatyana I. Igumenova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Protein kinase Cs (PKCs) define a central DAG-sensing node in intracellular phosphoinositide signaling pathways that regulate cell growth, differentiation, apoptosis, and motility. The structures of PKC C1 domain complexes with DAG and 4 agonists rev
Externí odkaz:
https://doaj.org/article/dfea0e544920424691cbd214fa44cc3d
Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy
Autor:
Taylor R. Cole, Tatyana I. Igumenova
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Conserved homology 1 (C1) domains are peripheral zinc finger domains that are responsible for recruiting their host signaling proteins, including Protein Kinase C (PKC) isoenzymes, to diacylglycerol-containing lipid membranes. In this work, we invest
Externí odkaz:
https://doaj.org/article/2b876b3316f14cc489101842f4eff94b
Autor:
Xiao-Ru Chen, Karuna Dixit, Yuan Yang, Mark I McDermott, Hasan Tanvir Imam, Vytas A Bankaitis, Tatyana I Igumenova
Publikováno v:
eLife, Vol 13 (2024)
Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P3 defines a major eukaryotic pathway for translation of extracellular cues to intracellular signaling circuits. Members of the
Externí odkaz:
https://doaj.org/article/0e0b2fd28a2a439ba2de545a4c16999f
Autor:
Xiao-Ru Chen, Tatyana I. Igumenova
Publikováno v:
Advances in biological regulation.
The peptidyl-prolyl isomerase Pin1 cooperates with proline-directed kinases and phosphatases to regulate multiple oncogenic pathways. Pin1 specifically recognizes phosphorylated Ser/Thr-Pro motifs in proteins and catalyzes their cis-trans isomerizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5590261ee99958472ea137ded41b94eb
https://pubmed.ncbi.nlm.nih.gov/36496344
https://pubmed.ncbi.nlm.nih.gov/36496344
Autor:
Xiao-Ru Chen, Lokendra Poudel, Zebin Hong, Philipp Johnen, Sachin S. Katti, Ashutosh Tripathi, Aaron H. Nile, Savana M. Green, Gabriel Schaaf, Fulvia Bono, Vytas A. Bankaitis, Tatyana I. Igumenova
Phosphatidylinositol transfer proteins (PITPs) promote phosphoinositide signaling by enhancing phosphatidylinositol (PtdIns) 4-OH kinase activities in producing signaling pools of PtdIns-4-phosphate. As such, PITPs are key regulators of lipid signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f31aa5de828fedec2a0eafc549cec3d
https://doi.org/10.1101/2022.08.01.502361
https://doi.org/10.1101/2022.08.01.502361
Autor:
Xiao‐Ru Chen, Tatyana I. Igumenova
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0434658a13c7cec32bd80c0296839b88
https://doi.org/10.1096/fasebj.2022.36.s1.l7818
https://doi.org/10.1096/fasebj.2022.36.s1.l7818
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd8b4411bb13227f0a6e23d7daa78c9
https://doi.org/10.1096/fasebj.2022.36.s1.l8086
https://doi.org/10.1096/fasebj.2022.36.s1.l8086
Autor:
Tatyana I. Igumenova, Sachin Katti
Publikováno v:
Metallomics. 12:164-172
Pb2+is a xenobiotic metal ion that competes for Ca2+-binding sites in proteins. Using the peripheral Ca2+-sensing domains of Syt1, we show that the chelating pH buffer Bis-Tris enables identification and functional characterization of high-affinity P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e63b1e2d8c09b1aa8c356939276ce8b
https://doi.org/10.1039/d0mt00002g
https://doi.org/10.1039/d0mt00002g
Autor:
Xiao-Ru Chen, Lokendra Poudel, Zebin Hong, Philipp Johnen, Sachin Katti, Ashutosh Tripathi, Aaron H. Nile, Savana M. Green, Danish Khan, Gabriel Schaaf, Fulvia Bono, Vytas A. Bankaitis, Tatyana I. Igumenova
Publikováno v:
Journal of Biological Chemistry. 299:102861
Phosphatidylinositol (PtdIns) transfer proteins (PITPs) enhance the activities of PtdIns 4-OH kinases that generate signaling pools of PtdIns-4-phosphate. In that capacity, PITPs serve as key regulators of lipid signaling in eukaryotic cells. Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1926bffdddf9ecd076069ca4d80be7e6
https://doi.org/10.1016/j.jbc.2022.102861
https://doi.org/10.1016/j.jbc.2022.102861
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists
Autor:
Sachin S. Katti, Inna V. Krieger, Jihyae Ann, Jeewoo Lee, James C. Sacchettini, Tatyana I. Igumenova
Publikováno v:
Nature communications. 13(1)
Diacylglycerol (DAG) is a versatile lipid whose 1,2-sn-stereoisomer serves both as second messenger in signal transduction pathways that control vital cellular processes, and as metabolic precursor for downstream signaling lipids such as phosphatidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e958663113ccdbd4b5a6a22bf26be91f
https://pubmed.ncbi.nlm.nih.gov/35577811
https://pubmed.ncbi.nlm.nih.gov/35577811