Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tatyana E. Kornienko"'
Autor:
Oksana V. Salomatina, Tatyana E. Kornienko, Alexandra L. Zakharenko, Nina I. Komarova, Chigozie Achara, Jóhannes Reynisson, Nariman F. Salakhutdinov, Olga I. Lavrik, Konstantin P. Volcho
Publikováno v:
Molecules, Vol 29, Iss 3, p 581 (2024)
Deoxycholic acid derivatives containing various heterocyclic functional groups at C-3 on the steroid scaffold were designed and synthesized as promising dual tyrosyl-DNA phosphodiesterase 1 and 2 (TDP1 and TDP2) inhibitors, which are potential target
Externí odkaz:
https://doaj.org/article/f7a6940d786f428597863fdfcc30635e
Autor:
Irina A. Chernyshova, Aleksandra L. Zakharenko, Nikolay N. Kurochkin, Nadezhda S. Dyrkheeva, Tatyana E. Kornienko, Nelly A. Popova, Valeriy P. Nikolin, Ekaterina S. Ilina, Timofey D. Zharkov, Maxim S. Kupryushkin, Vladimir E. Oslovsky, Mikhail S. Drenichev, Olga I. Lavrik
Publikováno v:
Molecules, Vol 28, Iss 1, p 323 (2022)
The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), a DNA-repair enzyme, that may prevent the acti
Externí odkaz:
https://doaj.org/article/1bed77c2f7a94878b8b6b1122def7fc2
Autor:
Aldar A. Munkuev, Nadezhda S. Dyrkheeva, Tatyana E. Kornienko, Ekaterina S. Ilina, Dmitry I. Ivankin, Evgeniy V. Suslov, Dina V. Korchagina, Yuriy V. Gatilov, Alexandra L. Zakharenko, Anastasia A. Malakhova, Jóhannes Reynisson, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Publikováno v:
Molecules, Vol 27, Iss 11, p 3374 (2022)
Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase
Externí odkaz:
https://doaj.org/article/bdfb05a221174f19bd958009695dc82d
Autor:
Dmitry I. Ivankin, Tatyana E. Kornienko, Marina A. Mikhailova, Nadezhda S. Dyrkheeva, Alexandra L. Zakharenko, Chigozie Achara, Jóhannes Reynisson, Victor M. Golyshev, Olga A. Luzina, Konstantin P. Volcho, Nariman F. Salakhutdinov, Olga I. Lavrik
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3834
Volume 24
Issue 4
Pages: 3834
Tyrosyl-DNA-phosphodiesterase 1 (TDP1) is a promising target for antitumor therapy; the use of TDP1 inhibitors with a topoisomerase 1 poison such as topotecan is a potential combination therapy. In this work, a novel series of 3,5-disubstituted thiaz
Autor:
Dmitry A. Stetsenko, Kristina A. Orlova, Ekaterina S Ilina, Nadezhda S Dyrkheeva, Nariman F. Salakhutdinov, Alexandra L. Zakharenko, Rashid O. Anarbaev, Sergey P. Medvedev, A.A. Malakhova, Aleksandr Filimonov, Tatyana E. Kornienko, Kristina Klabenkova, Konstantin N. Naumenko, Suren M. Zakian, Olga A. Luzina, Olga I. Lavrik, Ekaterina A. Burakova, Irina A. Chernyshova
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 21; Pages: 11336
International Journal of Molecular Sciences, Vol 22, Iss 11336, p 11336 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 11336, p 11336 (2021)
International Journal of Molecular Sciences
Tyrosyl-DNA phosphodiesterase 1 (TDP1) catalyzes the cleavage of the phosphodiester bond between the tyrosine residue of topoisomerase 1 (TOP1) and the 3′ phosphate of DNA in the single-strand break generated by TOP1. TDP1 promotes the cleavage of