Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tatyana B. Kalynyak"'
Autor:
Jessica A Hill, Marta Szabat, Corinne A Hoesli, Blair K Gage, Yu Hsuan C Yang, David E Williams, Michael J Riedel, Dan S Luciani, Tatyana B Kalynyak, Kevin Tsai, Ziliang Ao, Raymond J Andersen, Garth L Warnock, James M Piret, Timothy J Kieffer, James D Johnson
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cell
Externí odkaz:
https://doaj.org/article/4597d03eed1c4485a31e9ca5441e029a
Autor:
Emilyn U. Alejandro, K. J. Jacob, Kamila S. Gwiazda, James D. Johnson, Farnaz Taghizadeh, Tatyana B. Kalynyak, Erin K. Rawstron
Publikováno v:
Endocrinology. 151:502-512
Insulin enhances the proliferation and survival of pancreatic beta-cells, but its mechanisms remain unclear. We hypothesized that Raf-1, a kinase upstream of both ERK and Bad, might be a critical target of insulin in beta-cells. To test this hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967df5f8bb8b91f24fc64e6d1ab2bfd1
https://doi.org/10.1210/en.2009-0678
https://doi.org/10.1210/en.2009-0678
Autor:
Kristin D. Jeffrey, Ting-Lin B. Yang, Tatyana B. Kalynyak, James D. Johnson, Matthew H.Z. Frey, Yaryna Bychkivska, Dan S. Luciani, Arthur V. Sampaio, Kamila S. Gwiazda, T. Michael Underhill
Publikováno v:
Diabetes
OBJECTIVE—Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diabetes, but the roles of specific ER Ca2+ release channels in the ER stress–associated apoptosis pathway remain unknown. Here, we examined the effects of sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10551f9afbea6582e846716ce8b2496
https://doi.org/10.2337/db07-1762
https://doi.org/10.2337/db07-1762
Publikováno v:
Diabetologia. 50:2504-2515
The pathogenesis of diabetes and the success of islet transplantation depend on the control of pancreatic beta cell fate. The Notch signalling pathway is essential for normal prenatal pancreatic development, but the presence and function of this gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770f270bc019f6a1c3dabd488c3e9829
https://doi.org/10.1007/s00125-007-0835-5
https://doi.org/10.1007/s00125-007-0835-5
Autor:
Emilyn U. Alejandro, Ernesto Bernal-Mizrachi, Garth L. Warnock, M. Alan Permutt, Zhiqiang Han, Kenneth S. Polonsky, Tatyana B. Kalynyak, Raymond R. Townsend, Julia Gross, Hong Li, Jennifer L. Beith, James D. Johnson
Publikováno v:
Proceedings of the National Academy of Sciences. 103:19575-19580
Insulin is both a hormone regulating energy metabolism and a growth factor. We and others have shown that physiological doses of insulin initiate complex signals in primary human and mouse β-cells, but the functional significance of insulin's effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2f5db929a4c765bb7e34f8077af532
https://doi.org/10.1073/pnas.0604208103
https://doi.org/10.1073/pnas.0604208103
Autor:
Björn Hamberger, Erin J. Gilchrist, Sarah P. Otto, Fariba Aboutorabi, Joerg Bohlmann, Brian E. Ellis, Quentin C. B. Cronk, Tatyana B. Kalynyak, Lee A. JohnsonL.A. Johnson, Jun Zhuang, Carl J. Douglas, Dorothy Cheung, Cheng C. Ying, George W. Haughn
Publikováno v:
Molecular Ecology. 15:1367-1378
Ecotilling was used as a simple nucleotide polymorphism (SNP) discovery tool to examine DNA variation in natural populations of the western black cottonwood, Populus trichocarpa , and was found to be more efficient than sequencing for large-scale stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ab1873e88292992834b3978fec8456c
https://doi.org/10.1111/j.1365-294x.2006.02885.x
https://doi.org/10.1111/j.1365-294x.2006.02885.x
Autor:
Dan S. Luciani, Timothy J. Kieffer, James D. Johnson, Michael J. Riedel, Kevin Tsai, Ziliang Ao, Corinne A. Hoesli, James M. Piret, Tatyana B. Kalynyak, Marta Szabat, David E. Williams, Yu Hsuan Carol Yang, Raymond J. Andersen, Garth L. Warnock, Blair K. Gage, Jessica A. Hill
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ff5d2d1a60c10857e76deb5873ee1d
https://pubmed.ncbi.nlm.nih.gov/20886041
https://pubmed.ncbi.nlm.nih.gov/20886041
Autor:
James D. Johnson, Hong Li, Emilyn U. Alejandro, Kenneth S. Polonsky, Kristin D. Jeffrey, Xiaoke Hu, Tatyana B. Kalynyak, Yalin Lin, Raymond R. Townsend, Dan S. Luciani
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to identify targets of palmitate in β-cell death. The most significantly altered protein in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7243da52f0d8950b60e38450cc5c25
https://europepmc.org/articles/PMC2448857/
https://europepmc.org/articles/PMC2448857/
Autor:
Tatyana B. Kalynyak, Kristin D. Jeffrey, Dan S. Luciani, May Tee, Matthew H.Z. Frey, James D. Johnson, Vy Nguyen, Yaryna Bychkivska, Vardit Dror
Publikováno v:
The Journal of biological chemistry. 283(15)
Pancreatic beta-cell death is a critical event in type 1 diabetes, type 2 diabetes, and clinical islet transplantation. We have previously shown that prolonged block of ryanodine receptor (RyR)-gated release from intracellular Ca(2+) stores activates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cccb0adae5d0fc33ac0865cd45998c1
https://pubmed.ncbi.nlm.nih.gov/18174159
https://pubmed.ncbi.nlm.nih.gov/18174159