Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Tatyana A. Kurgina"'
1
Akademický článek
Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
Autor: Tatyana A. Kurgina, Nina A. Moor, Mikhail M. Kutuzov, Konstantin N. Naumenko, Alexander A. Ukraintsev, Olga I. Lavrik
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Kurgina et al. conduct in vitro characterization of the effect of HPF1 on the catalytic output of PARP1 and PARP2 under several experimental conditions. The authors report that the DNAdependent and DNA-independent autoPARylation of PARP1 and PARP2, a
Externí odkaz: https://doaj.org/article/e4c35787c23446cd93c6e3d3eff5af73
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2
Akademický článek
The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity
Autor: Konstantin N. Naumenko, Mariya V. Sukhanova, Loic Hamon, Tatyana A. Kurgina, Rashid O. Anarbaev, Aswin Mangerich, David Pastré, Olga I. Lavrik
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in the regulation of gene expression. Recent studies showed that in addition to its role in the RNA and DNA metabolism, YB-1 is involved in the regulation of PARP1 activity, which c
Externí odkaz: https://doaj.org/article/ba6af2193ffa4c1da6f06ac54d2a91b9
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3
Akademický článek
Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1
Autor: Konstantin N. Naumenko, Mariya V. Sukhanova, Loic Hamon, Tatyana A. Kurgina, Elizaveta E. Alemasova, Mikhail M. Kutuzov, David Pastré, Olga I. Lavrik
Publikováno v: Biomolecules, Vol 10, Iss 9, p 1325 (2020)
Y-box-binding protein 1 (YB-1) is a multifunctional positively charged protein that interacts with DNA or RNA and poly(ADP-ribose) (PAR). YB-1 is poly(ADP-ribosyl)ated and stimulates poly(ADP-ribose) polymerase 1 (PARP1) activity. Here, we studied th
Externí odkaz: https://doaj.org/article/2ccb3ea8872a487e8a10a3dbcc006a74
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4
Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly(ADP-Ribose) Polymerase 1
Autor: Tatyana A. Kurgina, Stanislav I. Shram, Mikhail M. Kutuzov, Tatyana V. Abramova, Tatyana A. Shcherbakova, Ekaterina A. Maltseva, Vladimir V. Poroikov, Olga I. Lavrik, Vytas K. Švedas, Dmitry K. Nilov
Publikováno v: Biochemistry. Biokhimiia. 87(8)
Previously, we have found that a nucleic acid metabolite, 7-methylguanine (7mGua), produced in the body can have an inhibitory effect on the poly(ADP-ribose) polymerase 1 (PARP1) enzyme, an important pharmacological target in anticancer therapy. In t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd583df87f40b7b425803f5d0dc4645
https://pubmed.ncbi.nlm.nih.gov/36171646
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5
The HPF1-dependent histone PARylation catalyzed by PARP2 is specifically stimulated by an incised AP site-containing BER DNA intermediate
Autor: Tatyana A. Kurgina, Nina A. Moor, Mikhail M. Kutuzov, Olga I. Lavrik
Publikováno v: DNA repair. 120
Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are DNA-dependent poly(ADP-ribose)transferases localized in nucleus. They have a significant homology in the C-terminal catalytic domain structure but differ in their N-terminal DNA-binding parts. The s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd67e29750ceaa7f51c0f67b10d95949
https://pubmed.ncbi.nlm.nih.gov/36356486
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6
The C-Terminal Domain of Y-Box Binding Protein 1 Exhibits Structure-Specific Binding to Poly(ADP-Ribose), Which Regulates PARP1 Activity
Autor: Konstantin N. Naumenko, Mariya V. Sukhanova, Loic Hamon, Tatyana A. Kurgina, Rashid O. Anarbaev, Aswin Mangerich, David Pastré, Olga I. Lavrik
Publikováno v: Frontiers in cell and developmental biology. 10
Y-box-binding protein 1 (YB-1) is a multifunctional protein involved in the regulation of gene expression. Recent studies showed that in addition to its role in the RNA and DNA metabolism, YB-1 is involved in the regulation of PARP1 activity, which c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0880d59e84bad21a03c5e766065168
https://pubmed.ncbi.nlm.nih.gov/35800891
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7
Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine
Autor: Tatyana A. Kurgina, N. S. Gerasimova, Mikhail A. Kutuzov, N. V. Maluchenko, Vasily M. Studitsky, Alexandra Lys, Olga I. Lavrik, Sergey Pushkarev, Alexey V. Feofanov, Vytas K. Švedas, D. K. Nilov
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2159 (2020)
International Journal of Molecular Sciences; Volume 21; Issue 6; Pages: 2159
7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can be considered as a potential anticancer drug candidate. Here we describe a study of 7-MG inhibition mechanism using molecular dynam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102d4cbfca40e6c213d01cb2b4d384af
https://pubmed.ncbi.nlm.nih.gov/32245127
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9
The multifunctional protein YB-1 potentiates PARP1 activity and decreases the efficiency of PARP1 inhibitors
Autor: Olga I. Lavrik, Tatyana A. Kurgina, Elizaveta E. Alemasova, Rashid O. Anarbaev, Konstantin N. Naumenko
Publikováno v: Oncotarget
Y-box-binding protein 1 (YB-1) is a multifunctional cellular factor overexpressed in tumors resistant to chemotherapy. An intrinsically disordered structure together with a high positive charge peculiar to YB-1 allows this protein to function in almo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dd7fe88644dc7aa3edb51aab3bdfbe
https://doi.org/10.18632/oncotarget.25158
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10
Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1
Autor: Loic Hamon, M. M. Kutuzov, Olga I. Lavrik, David Pastré, Tatyana A. Kurgina, Mariya V. Sukhanova, Konstantin N. Naumenko, Elizaveta E. Alemasova
Publikováno v: Biomolecules
Volume 10
Issue 9
Biomolecules, MDPI, 2020, 10 (9), pp.1325. ⟨10.3390/biom10091325⟩
Biomolecules, 2020, 10 (9), pp.1325. ⟨10.3390/biom10091325⟩
Biomolecules, Vol 10, Iss 1325, p 1325 (2020)
Y-box-binding protein 1 (YB-1) is a multifunctional positively charged protein that interacts with DNA or RNA and poly(ADP-ribose) (PAR). YB-1 is poly(ADP-ribosyl)ated and stimulates poly(ADP-ribose) polymerase 1 (PARP1) activity. Here, we studied th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7546cb543cded4e52a46afecfdf856
https://doi.org/10.3390/biom10091325
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