Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Tatsuya Toma"'
Autor:
Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, Michael J. Lenaeus, Matthew M. Logan, Tatsuya Toma, Justin Du Bois, Ning Zheng, William A. Catterall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The poison dart toxin batrachotoxin is exceptional for its high potency and toxicity, and for its multifaceted modification of the function of voltage-gated sodium channels. By using cryogenic electron microscopy, we identify two homologous,
Externí odkaz:
https://doaj.org/article/0cd0beb8ab5c4f2796f93d647ea54c87
Publikováno v:
Synlett. 33:391-395
A synthetic approach toward (–)-tetrodotoxin (TTX) is described. Our approach features a stereoselective construction of the TTX core structure using the bicyclo[2.2.2]octane skeleton which was constructed via intramolecular Diels–Alder reaction
Autor:
Nagayasu Nakajima, Eiji Yoshida, Tatsuya Toma, Yoshitake Nishiyama, Masayuki Inoue, Tohru Fukuyama, Satoshi Yokoshima
Publikováno v:
Organic letters. 24(44)
A synthetic route to ecteinascidin 743 has been established via an intramolecular cascade Heck reaction to construct the diazabicyclo[3.3.1]nonane skeleton while controlling the two contiguous stereogenic centers. The strategically formed five-member
Publikováno v:
Angewandte Chemie International Edition. 60(17):9666-9671
The total synthesis of haliclonin A was accomplished. Starting from 3,5-dimethoxybenzoic acid, a functionalized cyclohexanone fused to a 17-membered ring was prepared through a Birch reduction/alkylation sequence, ring-closing metathesis, intramolecu
Publikováno v:
Chemical and Pharmaceutical Bulletin. 69:278-280
We disclose our studies on a copper-mediated reaction of alkynes with trimethylsilyl azide to afford nitriles, and proposed a reaction mechanism, which involves an iodoalkyne and an iodotriazole as intermediates.
Publikováno v:
Synlett. 31(03):290-294
We disclose our synthetic studies on bilobalide, which features a Diels–Alder reaction of a cyclic anhydride to form two contiguous quaternary carbon centers, desymmetrization of a symmetric diol, and construction of a cyclic acetal under acidic co
Publikováno v:
Angewandte Chemie (International ed. in English). 59(15)
A total synthesis of tetrodotoxin was accomplished. A Diels–Alder reaction between a known enone and a siloxy diene gave a tricyclic product, the steric bias of which was used to construct the remaining stereogenic centers. A nitrogen atom was intr
Autor:
Logan, Matthew M.1,2, Tatsuya Toma1,3, Thomas-Tran, Rhiannon1,4, Du Bois, J.1 jdubois@stanford.edu
Publikováno v:
Science. 11/18/2016, Vol. 354 Issue 6314, p865-869. 5p. 3 Diagrams, 1 Graph.
Publikováno v:
ACS Chemical Neuroscience. 7:1463-1468
A novel family of small molecule inhibitors of voltage-gated sodium channels (Navs) based on the structure of batrachotoxin (BTX) – a well-known channel agonist – is described. Protein mutagenesis and electrophysiology experiments reveal the bind
Publikováno v:
Angewandte Chemie (International ed. in English). 56(6)
The enantioselective total synthesis of (−)-tetrodotoxin [(−)-TTX] and 4,9-anhydrotetrodotoxin, which are selective blockers of voltage-gated sodium channels, was accomplished from the commercially available p-benzoquinone. This synthesis was bas