Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Tatsuya Saitoh"'
Autor:
Ayako Fukunaka, Mari Shimura, Takayuki Ichinose, Ofejiro B. Pereye, Yuko Nakagawa, Yasuko Tamura, Wakana Mizutani, Ryota Inoue, Takato Inoue, Yuto Tanaka, Takashi Sato, Tatsuya Saitoh, Toshiyuki Fukada, Yuya Nishida, Takeshi Miyatsuka, Jun Shirakawa, Hirotaka Watada, Satoshi Matsuyama, Yoshio Fujitani
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Metal homeostasis is tightly regulated in cells and organisms, and its disturbance is frequently observed in some diseases such as neurodegenerative diseases and metabolic disorders. Previous studies suggest that zinc and iron are necessary
Externí odkaz:
https://doaj.org/article/21486bd9e52b4f68b855c665217669b8
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Humans are constantly exposed to various industrial, environmental, and endogenous particulates that result in inflammatory diseases. After being engulfed by immune cells, viz. Macrophages, such particulates lead to phagolysosomal dysfunc
Externí odkaz:
https://doaj.org/article/b29cb63609474557b4ac4ad9728a1c3c
Autor:
Satoshi Omori, Misato Tsugita, Yasuto Hoshikawa, Masanobu Morita, Fumiya Ito, Shin-Ichiro Yamaguchi, Qilin Xie, Osamu Noyori, Tomoya Yamaguchi, Ayato Takada, Tatsuya Saitoh, Shinya Toyokuni, Hisaya Akiba, Shigekazu Nagata, Kengo Kinoshita, Masafumi Nakayama
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108734- (2021)
Summary: Macrophage recognition and phagocytosis of crystals is critical for the associated fibrosis and cancer. Of note, multi-walled carbon nanotubes (MWCNTs), the highly representative products of nanotechnology, induce macrophage NLRP3 inflammaso
Externí odkaz:
https://doaj.org/article/c7b014b102d843bda38a9296ef0a0636
Autor:
Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2944-2954 (2017)
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored. Here, we show the involvement of a small GTPase,
Externí odkaz:
https://doaj.org/article/b3dd010512394109932e81b2181c56f3
Autor:
Lindsay DeVorkin, Nils Pavey, Gillian Carleton, Alexandra Comber, Cally Ho, Junghyun Lim, Erin McNamara, Haochu Huang, Paul Kim, Lauren G. Zacharias, Noboru Mizushima, Tatsuya Saitoh, Shizuo Akira, Wayne Beckham, Alireza Lorzadeh, Michelle Moksa, Qi Cao, Aditya Murthy, Martin Hirst, Ralph J. DeBerardinis, Julian J. Lum
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 502-513.e5 (2019)
Summary: Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the
Externí odkaz:
https://doaj.org/article/8607e5d2337e4062a9dcd40a4ca840f3
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Apoptosis occurs in numerous developmental processes but a role for necrosis in development is unclear. Here, the authors develop a detecting system of necrosis in the developing mouse and find a form of necrosis that is dependent on the autophagy-re
Externí odkaz:
https://doaj.org/article/316c703746a4409ab2ce03a8f139d368
Autor:
Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira, Masahiro Yamamoto
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 223-233 (2015)
Also known as Sqstm1, p62 is a selective autophagy adaptor with a ubiquitin-binding domain. However, the role of p62 in the host defense against Toxoplasma gondii infection is unclear. Here, we show that interferon γ (IFN-γ) stimulates ubiquitin an
Externí odkaz:
https://doaj.org/article/f7c7545e1935400d89b4106e5ebafe38
Autor:
Tomonobu M Watanabe, Yoshikazu Tsukasaki, Hideaki Fujita, Taro Ichimura, Tatsuya Saitoh, Shizuo Akira, Toshio Yanagida
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44028 (2012)
Optical microscopy is one of the most contributive tools for cell biology in the past decades. Many microscopic techniques with various functions have been developed to date, i.e., phase contrast microscopy, differential interference contrast (DIC) m
Externí odkaz:
https://doaj.org/article/b3ffdac109634c939231ff1d6efb3e03
Autor:
Yudai Matsui, Naoki Takemura, Yoshitaka Shirasaki, Michihiro Takahama, Yoshihiko Noguchi, Kenta Ikoma, Yixi Pan, Shuhei Nishida, Manabu Taura, Akiyoshi Nakayama, Takashi Funatsu, Takuma Misawa, Yoshie Harada, Toshiaki Sunazuka, Tatsuya Saitoh
Publikováno v:
International Immunology. 34:505-518
Nod-like receptor family pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune receptor that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic and drug stresses. Upon activation, NLRP3 form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887f6e025f51078eb497cc40996cb129
https://doi.org/10.1093/intimm/dxac028
https://doi.org/10.1093/intimm/dxac028
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:599-604
The purine nucleotide ATP is a fundamental unit in cellular energy metabolism. Extracellular ATP and its metabolites are also ligands for a family of receptors, known as purinergic receptors, which are expressed ubiquitously in almost every cell type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e0e2bc6fc7fe865688b66176464c90
https://doi.org/10.1248/bpb.b20-00831
https://doi.org/10.1248/bpb.b20-00831