Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tatsuya Okuzumi"'
Autor:
Takuya Seki, Kei Yamada, Yuri Ooba, Tomohiro Fujii, Takahiro Narita, Akira Nakayama, Yoshiro Kitahara, Brian A. Mendelsohn, Yutaka Matsuda, Tatsuya Okuzumi
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 8, p 234 (2022)
Background: Trastuzumab-emtansine (T-DM1, commercial name: Kadcyla) is well-known antibody-drug conjugate (ADC) and was first approved for human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. This molecular format consis
Externí odkaz:
https://doaj.org/article/c38f812fbc994049940757f4232ddaa8
Publikováno v:
Antibodies, Vol 9, Iss 2, p 16 (2020)
In recent years, site-specific antibody drug conjugates (ADC)s have been in great demand because they have an expanded therapeutic index compared with conventional ADCs. AJICAP™ technology is a chemical conjugation platform to obtain site-specific
Externí odkaz:
https://doaj.org/article/542e194d94a84f7fb592589aeb0ab3c4
Autor:
Tomohiro Fujii, Yutaka Matsuda, Takuya Seki, Natsuki Shikida, Yusuke Iwai, Yuri Ooba, Kazutoshi Takahashi, Muneki Isokawa, Sayaka Kawaguchi, Noriko Hatada, Tomohiro Watanabe, Rika Takasugi, Akira Nakayama, Kazutaka Shimbo, Brian A. Mendelsohn, Tatsuya Okuzumi, Kei Yamada
Publikováno v:
Bioconjugate Chemistry.
The site-directed chemical conjugation of antibodies remains an area of great interest and active efforts within the antibody-drug conjugate (ADC) community. We previously reported a unique site modification using a class of immunoglobulin-G (IgG) Fc
Autor:
Sayaka Kawaguchi, Yuri Ooba, Akira Nakayama, Yutaka Matsuda, Tatsuya Okuzumi, Fujii Tomohiro, Brian A. Mendelsohn, Kazutoshi Takahashi, Kei Yamada, Takuya Seki, Takahiro Narita, Yoshiro Kitahara
Publikováno v:
Molecular Pharmaceutics. 18:4058-4066
To overcome a lack of selectivity during the chemical modification of native non-engineered antibodies, we have developed a technology platform termed "AJICAP" for the site-specific chemical conjugation of antibodies through the use of a class of IgG
AJICAP™: Development of a Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugates
Autor:
Kei Yamada, Tatsuya Okuzumi
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 78:495-502
Autor:
Tatsuya Okuzumi, Atis Chakrabarti, Kei Yamada, Kazutoshi Takahashi, Kunio Nakata, Brian A. Mendelsohn, Yutaka Matsuda
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1177
Commercially approved conventional antibody-drug conjugates (ADCs) are produced as heterogeneous mixtures containing a stochastic distribution of payloads decorating the antibody molecules resulting in decreased efficacy and thus lowering their thera
Autor:
Yutaka Matsuda, Takuya Seki, Kei Yamada, Yuri Ooba, Kazutoshi Takahashi, Tomohiro Fujii, Sayaka Kawaguchi, Takahiro Narita, Akira Nakayama, Yoshiro Kitahara, Mendelsohn, Brian A., Tatsuya Okuzumi
Publikováno v:
Molecular Pharmaceutics; 11/1/2021, Vol. 18 Issue 11, p4058-4066, 9p
Publikováno v:
Journal of Combinatorial Chemistry. 5:756-759
Publikováno v:
Tetrahedron. 59:5603-5608
We have developed a method for the solid-phase synthesis of quinazoline-2,4-diones with various substituents on the aromatic ring. Although there have been numerous reports of the solid-phase synthesis of quinazoline-2,4-diones, they were not applica
Publikováno v:
Tetrahedron Letters. 41:3623-3626
Biosynthesis of the side-chain of sitosterol in higher plants involves two methylation steps by attack of S-adenosylmethionine. The stereochemical features of the second methylation, namely, of the conversion from 24-methylenecholesterol to isofucost