Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Tatsuya Ohyama"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Ligands that recognise specific i-motif DNAs are helpful in cancer diagnostics and therapeutics, as i-motif formation can cause cancer. Although the loop regions of i-motifs are promising targets for ligands, the interaction between a ligand
Externí odkaz:
https://doaj.org/article/965bb7cdba39409e935bae8f8433317d
Autor:
Kikuo Ikarashi, Hayato Shimomura, Jumpei Yasunaga, Takuya Ueki, Junichiro Ono, Tatsuya Ohyama
Publikováno v:
Japan Architectural Review, Vol 3, Iss 4, Pp 481-495 (2020)
Abstract Numerous studies have addressed the influence of the surrounding frame members on the in‐plane properties of steel shear walls with stiffeners. However, the effect of the out‐of‐plane stiffness on the buckling strength of stiffening pl
Externí odkaz:
https://doaj.org/article/5d1856b7864f48269f5f697a9c02230d
Autor:
Hisae Tateishi-Karimata, Tatsuya Ohyama, Takahiro Muraoka, Shigenori Tanaka, Kazushi Kinbara, Naoki Sugimoto
Publikováno v:
Molecules, Vol 25, Iss 3, p 705 (2020)
Methods for stabilizing G-quadruplex formation is a promising therapeutic approach for cancer treatment and other biomedical applications because stable G-quadruplexes efficiently inhibit biological reactions. Oligo and polyethylene glycols are promi
Externí odkaz:
https://doaj.org/article/f0bc9c3d319c4320a9d22e46476ccb04
Publikováno v:
Molecules, Vol 25, Iss 2, p 387 (2020)
The properties of non-canonical DNA structures, like G-quadruplexes and triplexes, change under cell-mimicking molecular crowding conditions relative to dilute aqueous solutions. The analysis of environmental effects on their stability is crucial sin
Externí odkaz:
https://doaj.org/article/5a4d77c20fc14307b0cf1a3acb298ce3
Autor:
Chiduru Watanabe, Shigenori Tanaka, Yoshio Okiyama, Hitomi Yuki, Tatsuya Ohyama, Kikuko Kamisaka, Daisuke Takaya, Kaori Fukuzawa, Teruki Honma
Publikováno v:
The Journal of Physical Chemistry Letters. 14:3609-3620
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e86000f3cea4708bfbd4e2054b629b
https://doi.org/10.1021/acs.jpclett.2c03768
https://doi.org/10.1021/acs.jpclett.2c03768
Autor:
Saptarshi Ghosh, Shuntaro Takahashi, Dipanwita Banerjee, Tatsuya Ohyama, Tamaki Endoh, Hisae Tateishi-Karimata, Naoki Sugimoto
Publikováno v:
Nucleic Acids Research. 51:4101-4111
RNA performs various spatiotemporal functions in living cells. As the solution environments significantly affect the stability of RNA duplexes, a stability prediction of the RNA duplexes in diverse crowded conditions is required to understand and mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b1cca5e598cb6276a7dd1f1888ced06
https://doi.org/10.1093/nar/gkad020
https://doi.org/10.1093/nar/gkad020
Publikováno v:
Analytical Chemistry. 94:7400-7407
Hydration around nucleic acids, such as DNA and RNA, is an important factor not only for the stability of nucleic acids but also for their interaction with binding molecules. Thus, it is necessary to quantitatively elucidate the hydration properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a41231f7c8fb86ac9c74a3d8127506
https://doi.org/10.1021/acs.analchem.2c01075
https://doi.org/10.1021/acs.analchem.2c01075
Autor:
Minori Nakata, Natsuki Kinoshita, Hisae Tateishi-Karimata, Takahito Nishikata, Tatsuya Ohyama, Keiko Kawauchi, Wataru Sugimoto, Daisuke Miyoshi, Naoki Sugimoto
Publikováno v:
Chemical Communications. 58:48-51
We identified cytosine-rich regions adjacent to guanine-rich regions in protease genes. A typical GC-rich sequence derived from the TMPRSS2 gene showed structural competition between a G-quadruplex and a hairpin loop, and this competition significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f11e4c0b1d2bad5e8911984cfb00dfba
https://doi.org/10.1039/d1cc05523b
https://doi.org/10.1039/d1cc05523b
Autor:
Chiduru Watanabe, Shigenori Tanaka, Yoshio Okiyama, Hitomi Yuki, Tatsuya Ohyama, Kikuko Kamisaka, Daisuke Takaya, Kaori Fukuzawa, Teruki Honma
A non-covalent oral drug targeting severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) main protease (Mpro), ensitrelvir (brand name Xocova), has been developed by Unoh et al. (J. Med. Chem. 2022, 65, 9, 6499–6512) using structure-based dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1092026b76b6be8c6f7183c157da27a3
https://doi.org/10.26434/chemrxiv-2022-drwc0
https://doi.org/10.26434/chemrxiv-2022-drwc0
Autor:
Shuntaro Takahashi, Tamaki Endoh, Hisae Tateishi-Karimata, Saptarshi Ghosh, Dipanwita Banerjee, Naoki Sugimoto, Tatsuya Ohyama
Publikováno v:
Nucleic Acids Research. 49:10796-10799
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb067ab2b65c74c89f74207750ff7708
https://doi.org/10.1093/nar/gkab780
https://doi.org/10.1093/nar/gkab780