Výsledky vyhledávání - "Tatsuya Niimi"

Akademický článek

DLiP-PPI library: An integrated chemical database of small-to-medium-sized molecules targeting protein–protein interactions

Autor: Kazuyoshi Ikeda, Yuta Maezawa, Tomoki Yonezawa, Yugo Shimizu, Toshiyuki Tashiro, Satoru Kanai, Nobuyoshi Sugaya, Yoshiaki Masuda, Naoko Inoue, Tatsuya Niimi, Keiichi Masuya, Kenji Mizuguchi, Toshio Furuya, Masanori Osawa

Publikováno v: Frontiers in Chemistry, Vol 10 (2023)

Protein–protein interactions (PPIs) are recognized as important targets in drug discovery. The characteristics of molecules that inhibit PPIs differ from those of small-molecule compounds. We developed a novel chemical library database system (DLiP

Externí odkaz: https://doaj.org/article/42cbdb75873e4e278b556cd412d3723b

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Akademický článek

Running-in friction of hip joint replacements can be significantly reduced: The effect of surface-textured acetabular cup

Autor: David Nečas, Hatsuhiko Usami, Tatsuya Niimi, Yoshinori Sawae, Ivan Křupka, Martin Hartl

Publikováno v: Friction, Vol 8, Iss 6, Pp 1137-1152 (2020)

Abstract Hip joint replacements represent the most effective way of treatment for patients suffering from joint diseases. Despite the rapid improvement of implant materials over the last few decades, limited longevity associated with wear-related com

Externí odkaz: https://doaj.org/article/006342fccc794ba980096b7c8c346a60

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Akademický článek

In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease

Autor: Ryunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, Takashi Ishida, Daniel Ken Inaoka, Yasushi Amano, Yukihiro Tateishi, Kazuki Ohno, Ichiji Namatame, Tatsuya Niimi, Masaya Orita, Kiyoshi Kita, Yutaka Akiyama, Masakazu Sekijima

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Chagas disease results from infection by Trypanosoma cruzi and is a neglected tropical disease (NTD). Although some treatment drugs are available, their use is associated with severe problems, including adverse effects and limited effectiven

Externí odkaz: https://doaj.org/article/9864fe2ce67f43499bde2b3251ec52d6

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Data from Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non–Small Cell Lung Cancer

Autor: Tomoko Betsuyaku, Kenzo Soejima, Hideki Sakagami, Shinya Mimasu, Tatsuya Niimi, Katsuhiko Naoki, Ichiro Kawada, Keita Masuzawa, Shigenari Nukaga, Junko Hamamoto, Hiroyuki Yasuda, Toshiyuki Hirano

Multiple epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKI) have been developed to effectively inhibit EGFR-derived signals in non–small cell lung cancer (NSCLC). In this study, we assessed the efficacy of EGFR-TKIs, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f63728dc4a949b18cd18bfd9c4e456bd
https://doi.org/10.1158/1535-7163.c.6537946.v1

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Supplementary Tables S1-4 from Pharmacological and Structural Characterizations of Naquotinib, a Novel Third-Generation EGFR Tyrosine Kinase Inhibitor, in EGFR-Mutated Non–Small Cell Lung Cancer

Table S1:IC50 values of EGFR-TKIs for lung cancer cell lines. Table S2:IC50 values of EGFR-TKIs for Ba/F3 cells harboring EGFR exon 20 insertion mutations. Table S3:IC50 values of EGFR-TKIs for Ba/F3 cells harboring EGFR L858R or L858R+Y764_V765insHH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755b2f885ea3f1f1a3bdc8b940846f70
https://doi.org/10.1158/1535-7163.22505092

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Fundamental research on Japanese language education and career path connectivity in ASEAN countries

Autor: Tatsuya Niimi

Publikováno v: Impact. 2023:10-11

Although Japan is a major powerhouse, it is experiencing issues with a low birth rate and ageing population. The impact of these issues on the workforce could be significant. There are other ASEAN countries that are still considered developing nation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16b1a651494db801372b134e3a604f95
https://doi.org/10.21820/23987073.2023.1.10

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Discovering a hidden binding site of spermidine synthase inhibitors for Chagas disease by combining molecular simulations and X-ray crystallography

Autor: Daniel Ken Inaoka, Masakazu Sekijima, Takashi Ishida, Yutaka Akiyama, Masaya Orita, Kiyoshi Kita, Yukihiro Tateishi, Ryunosuke Yoshino, Tatsuya Niimi, Yohsuke Hagiwara, Kazuki Ohno, Ichiji Namatame, Yasushi Amano, Nobuaki Yasuo

Background Chagas disease is caused by the parasite Trypanosoma cruzi and is one of the neglected tropical diseases. Although two types of drugs are currently available, new drugs are still required because they have serious side effects. To develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cd2fda5448f2fe1c6d1d106de6a02a
https://doi.org/10.26434/chemrxiv-2021-qk2ns

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Running-in friction of hip joint replacements can be significantly reduced: The effect of surface-textured acetabular cup

Autor: Tatsuya Niimi, Hatsuhiko Usami, Yoshinori Sawae, Martin Hartl, Ivan Křupka, D. Nečas

Publikováno v: Friction. 2020, vol. 8, issue 6, p. 1137-1152.
Friction, Vol 8, Iss 6, Pp 1137-1152 (2020)

Hip joint replacements represent the most effective way of treatment for patients suffering from joint diseases. Despite the rapid improvement of implant materials over the last few decades, limited longevity associated with wear-related complication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07150d1017a652e2901a3c9dcc174101
https://hdl.handle.net/11012/194774

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