Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tatsuya Mizoroki"'
Autor:
Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattori
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 404-414 (2011)
Tauopathies differ in terms of the brain regions that are affected. In Alzheimer's disease, basal forebrain and hippocampus are mainly involved, while frontotemporal lobar degeneration affects the frontal and temporal lobes and subcortical nuclei inc
Externí odkaz:
https://doaj.org/article/787eb3407d0a4acfa2eab1ab91ddc2f6
Autor:
Tetsuya Kimura, Shunji Yamashita, Shinobu Nakao, Jung-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3540 (2008)
Activation of GSK-3beta is presumed to be involved in various neurodegenerative diseases, including Alzheimer's disease (AD), which is characterized by memory disturbances during early stages of the disease. The normal function of GSK-3beta in adult
Externí odkaz:
https://doaj.org/article/9434b8ac212e4c6abdb5e26a950cdab0
Autor:
Yuji Yoshiike, Tetsuya Kimura, Shunji Yamashita, Hiroyuki Furudate, Tatsuya Mizoroki, Miyuki Murayama, Akihiko Takashima
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e3029 (2008)
Advanced age and mutations in the genes encoding amyloid precursor protein (APP) and presenilin (PS1) are two serious risk factors for Alzheimer's disease (AD). Finding common pathogenic changes originating from these risks may lead to a new therapeu
Externí odkaz:
https://doaj.org/article/d14f293d5e5642e4a97669ff23a16901
Autor:
Shunji Yamashita, Tatsuya Mizoroki, Miyuki Murayama, Akihiko Takashima, Yoshiyuki Soeda, Tetsuya Kimura, Yuji Yoshiike, Sumihiro Maeda, Naruhiko Sahara
Publikováno v:
Aging Cell. 11:51-62
Oxidative stress is considered to promote aging and age-related disorders such as tauopathy. Although recent reports suggest that oxidative stress under certain conditions possesses anti-aging properties, no such conditions have been reported to amel
Autor:
Yoshikuni Mizuno, Ran Inoue, Shunji Yamashita, Hiroshi Mizuma, Nobuhiko Kojima, Taiki Kambe, Naruhiko Sahara, Kohei Shimada, Nobutaka Hattori, Tatsuya Mizoroki, Norihiro Tada, Hirotaka Onoe, Akihiko Takashima, Yumiko Motoi, Koichi Ishiguro, Tetsuya Kimura
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 404-414 (2011)
Tauopathies differ in terms of the brain regions that are affected. In Alzheimer's disease, basal forebrain and hippocampus are mainly involved, while frontotemporal lobar degeneration affects the frontal and temporal lobes and subcortical nuclei inc
Autor:
Yoshiro Saito, Tomohiro Miyasaka, Akira Kobayashi, Yasuo Ihara, Tomoko Morita, Noriko Noguchi, Fumiki Katsuoka, Makiko Ohtsuji, Akihiko Takashima, Akiyoshi Fukamizu, Yosuke Hirotsu, Tatsuya Mizoroki, Masayuki Yamamoto, Takako Tsukide
Publikováno v:
Genes to Cells. 16:692-703
Cap'n'Collar (CNC) proteins heterodimerize with small Maf proteins and regulate the transcription of various genes. Small Maf-deficient mice develop severe neurodegeneration, and it remains unclear whether CNC proteins are involved in this process. I
Autor:
Koji Iwanaga, Toshio Nagai, Hiroshi Akazawa, Issei Komuro, Sho Okada, Tohru Minamino, Tomokazu Sumida, Seitaro Nomura, Ichiro Shiojima, Naruhiko Sahara, Atsuhiko T. Naito, Akihiko Takashima, Tatsuya Mizoroki, Mei-Lan Liu
Publikováno v:
Circulation Research. 106:1692-1702
Rationale : The number of patients with coronary heart disease, including myocardial infarction, is increasing and novel therapeutic strategy is awaited. Tumor suppressor protein p53 accumulates in the myocardium after myocardial infarction, causes a
Autor:
Tetsuya Kimura, Yuji Yoshiike, Akihiko Takashima, Tatsuya Mizoroki, Shunji Yamashita, Miyuki Murayama, Jun-Mi Park, Tetsuya Fukuda, Naruhiko Sahara
Publikováno v:
The EMBO Journal. 26:5143-5152
To investigate how tau affects neuronal function during neurofibrillary tangle (NFT) formation, we examined the behavior, neural activity, and neuropathology of mice expressing wild-type human tau. Here, we demonstrate that aged (>20 months old) mice
Autor:
Sumihiro Maeda, Tatsuya Mizoroki, Naruhiko Sahara, Miyuki Murayama, Shunsuke Meshitsuka, Akihiko Takashima
Publikováno v:
Journal of Alzheimer's Disease. 11:419-427
Etiological studies suggest that aluminum (Al) intake might increase an individual's risk of developing Alzheimer's disease (AD). Biochemical analysis data on the effects of Al, however, are inconsistent. Hence, the pathological involvement of Al in
Autor:
Miyuki Murayama, Shigeo Murata, Akihiko Takashima, Keiji Tanaka, Ryosuke Takahashi, Tatsuya Mizoroki, Makoto Urushitani, Naruhiko Sahara, Yuzuru Imai
Publikováno v:
Journal of Neurochemistry. 94:1254-1263
The carboxyl terminus of heat-shock cognate (Hsc)70-interacting protein (CHIP) is a ubiquitin E3 ligase that can collaborate with molecular chaperones to facilitate protein folding and prevent protein aggregation. Previous studies showed that, togeth