Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tatsuya Kiso"'
Autor:
Takafumi Nagatomo, Yoko Hanaoka, Takao Kakita, Ikunobu Muramatsu, Tatsuya Kiso, Yoshikazu Ohtsubo, Maruf Ahmed
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:75-81
We evaluated six new compounds, SWR-0065HA ([4-[2-[3-[[(3,4-dihydro-4-oxo-[1,2,4]-triazino(4,5-a)indol)-lyl]oxy]-2-hydroxypropylamino]ethoxy]phenyl]acetic acid methyl ester hydrochloride), SWR-0098NA ((R*R*-UE)-(E)-[4-[3-[(2-phenyl-2-hydroxyethyl)ami
Autor:
Yoshikazu Ohtsubo, Hideki Kishine, Tatsuya Kiso, Yoshiharu Matsubara, Akiyoshi Sawabe, Toshie Minematsu, Masanori Morita, Tadashi Okamoto
Publikováno v:
Carbohydrate Research. 315:142-147
Three limonoid glycosides were isolated from Citrus unshiu peels, and their structures were determined based on MS and NMR spectroscopic data as nomilinic acid 17-O-beta-D-glucopyranoside (1), methyl nomilinate 17-O-beta-D-glucopyranoside (2), and ob
Autor:
Takao Kakita, Takeshi Shogaki, Hirofumi Kataoka, Takashi Isoi, Yoshikazu Ohtsubo, Ranjun Shinkawa, Tatsuya Kiso
Publikováno v:
YAKUGAKU ZASSHI. 116:783-791
The antagonism of histamine H2-receptor by SWR-104SA (1'-bromo-N-[3-[3-(1-piperidinylmethyl) phenoxy] propyl]-spiro [1,3-dioxolane-2,9'-pentacyclo-[4.3.0.0.(2,5)0.(3,8) 0.(4,7)]nonane]-4'-carboxamide monooxalate) was estimated using the isolated guin
Autor:
Yoshiharu Matsubara, Toshie Minematsu, Yoshikazu Ohtsubo, Hideki Kishine, Tadashi Okamoto, Masanori Morita, Akiyoshi Sawabe, Tatsuya Kiso
Publikováno v:
ChemInform. 30
Publikováno v:
Biologicalpharmaceutical bulletin. 27(5)
The pharmacological properties of SWR-0315NA, (E,Z)-[4[[1-[2-[(3-phenoxy-2-hydroxy propyl)]amino]ethyl]-1-propenyl]phenoxy]acetic acid sodium, were compared with those of (-)-isoproterenol. In the radioligand binding studies of [(125)I]iodocyanopindo
Autor:
Takao Kakita, Taku Nagao, Yoko Hanaoka, Tatsuya Kiso, Hitoshi Kurose, Takafumi Nagatomo, Maruf Ahmed
Publikováno v:
The Journal of pharmacy and pharmacology. 55(1)
β3-Adrenoceptor is the predominant β-adrenoceptor in adipocytes and has drawn much attention during the investigation for anti-obesity and antidiabetes therapeutics. Thirteen new compounds have been evaluated for their potencies and efficacies as
Autor:
Tatsuya Kiso, Seiji Ouchi, Yoshikazu Ohtsubo, Tadashi Okamoto, Masanori Morita, Hideki Kishine, Akiyoshi Sawabe
Publikováno v:
Journal of agricultural and food chemistry. 47(2)
New polyisoprenepolyols (hypsiziprenol AA and BA) were isolated from an edible mushroom (Hypsizigus marmoreus). These polyols occur as a mixture of homologous polyisoprene derivatives with 40-70 carbon atoms. Analyses by FAB/MS in the positive and ne
Autor:
Takeshi Shogaki, Takao Kakita, Tatsuya Kiso, Tomoko Namikawa, Yoshikazu Ohtsubo, Tetsuhiro Tokunaga, Kazuyuki Sawada
Publikováno v:
Biologicalpharmaceutical bulletin. 22(10)
We investigated the beta-adrenergic receptor (AR) agonistic activities in rats and humans, and the anti-obesity and anti-diabetic activities in KK-Ay mice, of a new beta3-AR agonist, SWR-0342SA ((S)-(Z)-[4-[[1-[2-[(2-hydroxy-3-phenoxypropyl)]amino]et
Publikováno v:
Biologicalpharmaceutical bulletin. 22(7)
To investigate the effects of vasoactive intestinal peptide (VIP) on Cl- transport across normal human bronchial epithelial (NHBE) cells grown in a monolayer, changes in short-circuit current (Isc) were measured in Ussing chamber systems. In the pres
Autor:
Ranjun Shinkawa, Yoshikazu Ohtsubo, Takeshi Shogaki, Chizu Tanaka, Takao Kakita, Hirohumi Kataoka, Masumi Furukawa, Tatsuya Kiso, Takashi Isoi
Publikováno v:
Biologicalpharmaceutical bulletin. 20(1)
We investigated the effects of a new antiulcer agent, SWR-215 ([[(1,2-dihydro-2-oxo-4-quinolinyl)methyl]thio]-N-[[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-Z-2-butenyl]acetamide), on histamine H 2 -receptors, gastric acid secretion and various acute