Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Tatsuya Kin"'
Autor:
Alessandro Parente, MD, PhD, Kevin Verhoeff, MD, PhD, Tatsuya Kin, MD, PhD, Joshua Hefler, MD, PhD, Braulio A. Marfil-Garza, MD, PhD, Norberto Sanchez-Fernandez, MD, Anna Lam, MD, MSc, James Lyon, MD, PhD, Doug O’Gorman, BSc, Khaled Z. Dajani, MD, Blaire L. Anderson, MD, David L. Bigam, MD, MSc, Patrick E. MacDonald, MD, PhD, A. M. James Shapiro, MD, PhD, FRCS (Eng), FRCSC, MSM
Publikováno v:
Transplantation Direct, Vol 10, Iss 7, p e1667 (2024)
Background. Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors. Me
Externí odkaz:
https://doaj.org/article/71afa965af904b5c8fc2cf5045e23fbe
Autor:
Junko Nishida, Takahiro Tsuno, Shigeharu G. Yabe, Tatsuya Kin, Satsuki Fukuda, Fujie Takeda, Jun Shirakawa, Hitoshi Okochi
Publikováno v:
Endocrine Journal, Vol 71, Iss 3, Pp 253-264 (2023)
Maintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distri
Externí odkaz:
https://doaj.org/article/17d1b3ba3e4c4e2ebeddff52c66c992b
Autor:
Shareen Forbes, Anne Halpin, Anna Lam, Don Grynoch, Richard Parker, Luis Hidalgo, David Bigam, Blaire Anderson, Khaled Dajani, Tatsuya Kin, Doug O'Gorman, Peter A. Senior, Patricia Campbell, A.M. James Shapiro
Publikováno v:
EClinicalMedicine, Vol 67, Iss , Pp 102333- (2024)
Summary: Background: In solid organ transplantation, HLA matching between donor and recipient is associated with superior outcomes. In islet transplantation, an intervention for Type 1 diabetes, HLA matching between donor and recipient is not perform
Externí odkaz:
https://doaj.org/article/0b2972dd9f5648268b9c64e922467b66
Autor:
Alexander U. Ernst, Long-Hai Wang, Scott C. Worland, Braulio A. Marfil-Garza, Xi Wang, Wanjun Liu, Alan Chiu, Tatsuya Kin, Doug O’Gorman, Scott Steinschneider, Ashim K. Datta, Klearchos K. Papas, A. M. James Shapiro, Minglin Ma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Transplanting encapsulated insulin-producing cells may achieve a functional cure for type 1 diabetes, but efficacy is constrained by mass transfer limits. Here, the authors report a dynamic computational platform to investigate the therapeutic potenc
Externí odkaz:
https://doaj.org/article/1a9adbcc80c7442e8935f64bbb94e3f8
Autor:
Jun Shirakawa, Yu Togashi, Giorgio Basile, Tomoko Okuyama, Ryota Inoue, Megan Fernandez, Mayu Kyohara, Dario F. De Jesus, Nozomi Goto, Wei Zhang, Takahiro Tsuno, Tatsuya Kin, Hui Pan, Jonathan M. Dreyfuss, A.M. James Shapiro, Peng Yi, Yasuo Terauchi, Rohit N. Kulkarni
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111436- (2022)
Summary: Prevention or amelioration of declining β cell mass is a potential strategy to cure diabetes. Here, we report the pathways utilized by β cells to robustly replicate in response to acute insulin resistance induced by S961, a pharmacological
Externí odkaz:
https://doaj.org/article/3143a9f198114e48a593ab4fa7acda69
Autor:
Caterina Iorio, Jillian L. Rourke, Lisa Wells, Jun-Ichi Sakamaki, Emily Moon, Queenie Hu, Tatsuya Kin, Robert A. Screaton
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Caterina Iorio et al. use a high-throughput RNAi screen to identify the GPR3-SIK2-CDKN1B axis as key players involved in regulating pancreatic beta cell proliferation. These results suggest that GPR3 and SIK2 are both potential targets to stimulate r
Externí odkaz:
https://doaj.org/article/dec25cc1168a4f9bbbd67253be002483
Autor:
Ryota Inoue, Takahiro Tsuno, Yu Togashi, Tomoko Okuyama, Aoi Sato, Kuniyuki Nishiyama, Mayu Kyohara, Jinghe Li, Setsuko Fukushima, Tatsuya Kin, Daisuke Miyashita, Yusuke Shiba, Yoshitoshi Atobe, Hiroshi Kiyonari, Kana Bando, A.M. James Shapiro, Kengo Funakoshi, Rohit N. Kulkarni, Yasuo Terauchi, Jun Shirakawa
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104603- (2022)
Summary: Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear. In this stu
Externí odkaz:
https://doaj.org/article/749f21feddc94cc29bd880275707990e
Autor:
Ami Watanabe, Anna Tanaka, Chizuko Koga, Masahito Matsumoto, Yasushi Okazaki, Tatsuya Kin, Atsushi Miyajima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Generation of pancreatic β cells from pluripotent stem cells is a key technology to develop cell therapy for insulin-dependent diabetes and considerable efforts have been made to produce β cells. However, due to multiple and lengthy differ
Externí odkaz:
https://doaj.org/article/0045ce09fa434bfe9dd473e76af13f0e
Publikováno v:
EBioMedicine, Vol 50, Iss , Pp 306-316 (2019)
Background: The understanding of the regulation of glucagon secretion by pancreatic islet α-cells remains elusive. We aimed to develop an in vitro model for investigating the function of human α-cells under direct influence of glucose and other pot
Externí odkaz:
https://doaj.org/article/ecd348bbb2ea4988b0fe368a3ceedade
Autor:
Hirofumi Noguchi, Chika Miyagi-Shiohira, Yoshiki Nakashima, Takao Kinjo, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, A. M. James Shapiro, Tatsuya Kin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 243-252 (2019)
We recently demonstrated the generation of mouse induced tissue-specific stem (iTS) cells through transient overexpression of reprogramming factors combined with tissue-specific selection. Here we induced expandable tissue-specific progenitor (iTP) c
Externí odkaz:
https://doaj.org/article/5767112959d040c5ae59cd02073c1b98