Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tatsuya Kibe"'
Autor:
Francisca Lottersberger, Daniel Durocher, Tatsuya Kibe, Kaori K. Takai, Titia de Lange, Hiroyuki Takai, Alessandro Bianchi, Michal Zimmermann, Zachary Mirman, Yi Gong
Publikováno v:
Nature
In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair—which requires a 3′ overhang—and classical non-homologous end joining, which can join unresected ends1,2. BRCA1-mutant cancers show minima
Publikováno v:
Molecular cell. 66(2)
The regulation of 5' end resection at DSBs and telomeres prevents genome instability. DSB resection is positively and negatively regulated by ATM signaling through CtIP/MRN and 53BP1-bound Rif1, respectively. Similarly, telomeres lacking TRF2 undergo
Publikováno v:
Genes & Development. 28:2477-2491
The semiconservative replication of telomeres is facilitated by the shelterin component TRF1. Without TRF1, replication forks stall in the telomeric repeats, leading to ATR kinase signaling upon S-phase progression, fragile metaphase telomeres that r
Publikováno v:
Molecular Cell. 44(4):647-659
To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclusion. However, comparison of the DNA binding affinitie
Publikováno v:
Molecular and Cellular Biology. 30:1059-1066
Mammalian telomeres are protected by the shelterin complex, which contains single-stranded telomeric DNA binding proteins (POT1a and POT1b in rodents, POT1 in other mammals). Mouse POT1a prevents the activation of the ATR kinase and contributes to th
Autor:
Yeon-Soo Seo, Masaru Ueno, Takashi Ushimaru, Kazunori Tomita, Masahiro Uritani, Hoyoung Kang, Tatsuya Kibe
Publikováno v:
Molecular and cellular biology. 24:9557-9567
It has been suggested that the Schizosaccharomyces pombe Rad50 (Rad50-Rad32-Nbs1) complex is required for the resection of the C-rich strand at telomere ends in taz1-d cells. However, the nuclease-deficient Rad32-D25A mutant can still resect the C-ri
Autor:
Masashi Yukawa, Tatsuya Kibe, Norihiko Nakazawa, Masaru Ueno, Genki Tanaka, Katsunori Takahashi, Eiko Tsuchiya, Taisuke Hiromoto, Ryota Imano, Hiroyuki Seimiya, Yuka Koizumi, Yoshitake Matsumoto, Naoki Kawabata, Mitsuhiro Yanagida, Yukiko Muramatsu
Pot1 is a single-stranded telomere-binding protein that is conserved from fission yeast to mammals. Deletion of Schizosaccharomyces pombe pot1(+) causes immediate telomere loss. S. pombe Rqh1 is a homolog of the human RecQ helicase WRN, which plays e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb993f8eb845b4b1e07bc1734f919da
http://ir.lib.hiroshima-u.ac.jp/00033044
http://ir.lib.hiroshima-u.ac.jp/00033044
Autor:
Masaru Ueno, Koichiro Sato, Asako J. Nakamura, Tatsuya Kibe, Yuka Kobayashi, Masashi Yukawa, Hiroyuki Seimiya, Eiko Tsuchiya
Publikováno v:
Bioscience, biotechnology, and biochemistry. 74(2)
Replication protein A (RPA) binds to single-stranded DNA generated during DNA replication and other processes. The roles of RPA in telomere maintenance have been demonstrated in yeasts, but not in telomerase-positive human cells. In this study, we fo
Publikováno v:
Molecular and cellular biology. 29(2)
The single-stranded telomeric DNA binding protein POT1 protects mammalian chromosome ends from the ATR-dependent DNA damage response, regulates telomerase-mediated telomere extension, and limits 5'-end resection at telomere termini. Whereas most mamm
Autor:
Akira Matsuura, Daisuke Izawa, Takashi Ushimaru, Masaru Ueno, Kazunori Tomita, Masahiro Uritani, Tatsuya Kibe, Tsutomu Kodaira
Publikováno v:
Nucleic acids research. 31(17)
The Schizosaccharomyces pombe Ku70-Ku80 heterodimer is required for telomere length regulation. Lack of pku70+ results in telomere shortening and striking rearrangements of telomere-associated sequences. We found that the rearrangements of telomere-a