Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Tatsuya Horio"'
Autor:
Hiroki Hayase, Shinsaku Itou, Tatsuya Horio, Tomohiro Hamasaki, Toshihiko Inoue, Tomoko Niwa, Tetsuo Asaki, Haruna Naito, Tatsushi Wakayama
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2712-2717
To investigate why 3-substituted benzamide derivatives show dual inhibition of Abl and Lyn protein tyrosine kinases, we determined their inhibitory activities against Abl and Lyn, carried out molecular modeling, and conducted a structure-activity rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8f869f000a245e129f7d5f0cea388e
https://doi.org/10.1016/j.bmcl.2007.03.002
https://doi.org/10.1016/j.bmcl.2007.03.002
Autor:
Yoshinori Kaminishi, Susumu Katsuma, Junichi Yano, Teruo Tanaka, Kazuchika Takagaki, Tadaaki Ohgi, Tatsuya Horio
Publikováno v:
Genes to Cells. 10:97-106
Human chronic myelogenous leukemia K562 cells are relatively resistant to the anti-metabolite cytosine arabinoside (Ara-C) and, when treated with Ara-C, they differentiate into erythrocytes without undergoing apoptosis. In this study we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79571b8481a5b8c44df1a58459ef8daa
https://doi.org/10.1111/j.1365-2443.2005.00821.x
https://doi.org/10.1111/j.1365-2443.2005.00821.x
Autor:
Junichi Yano, Yuko Hada, Kazuchika Takagaki, Teruo Tanaka, Susumu Katsuma, Tatsuya Horio, Yoshinori Kaminishi, Tadaaki Ohgi
Publikováno v:
Biochemical and Biophysical Research Communications. 309:351-358
The acute lymphoblastic leukemia cell line CCRF-CEM is sensitive to Ara-C and undergoes apoptosis. In contrast, the chronic myelogenous leukemia (CML) cell line K562 is highly resistant to Ara-C, which causes the cells to differentiate into erythrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272701672b1b30ce19f32a2ba67b75f2
https://doi.org/10.1016/j.bbrc.2003.08.009
https://doi.org/10.1016/j.bbrc.2003.08.009
Publikováno v:
The XIX International Conference on Electrical Machines - ICEM 2010.
Optical scanners are applicable to various devices, for example, a distribution system and a handy terminal (potable instrument). Potable instruments are expected to work precisely and efficiently. They must be miniaturized and thinned. The authors m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff7e9384acd56303b2108c65ac937a7
https://doi.org/10.1109/icelmach.2010.5608199
https://doi.org/10.1109/icelmach.2010.5608199
Autor:
Kazuchika, Takagaki, Susumu, Katsuma, Yoshinori, Kaminishi, Tatsuya, Horio, Teruo, Tanaka, Tadaaki, Ohgi, Junichi, Yano
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 10(2)
Human chronic myelogenous leukemia K562 cells are relatively resistant to the anti-metabolite cytosine arabinoside (Ara-C) and, when treated with Ara-C, they differentiate into erythrocytes without undergoing apoptosis. In this study we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe9b56a133b2b9048f3d1faf1756a17d
https://pubmed.ncbi.nlm.nih.gov/15676021
https://pubmed.ncbi.nlm.nih.gov/15676021
Autor:
Tatsuya Horio, Teruo Tanaka, Shinichiro Nakagawa, Tadaaki Ohgi, Junichi Yano, Susumu Katsuma, Kazuchika Takagaki, Yoshinori Kaminishi
Publikováno v:
Journal of biochemistry. 136(5)
We have investigated the mechanism of resistance of leukemia cells to Ara-C using an in-house cDNA microarray designed for the analysis of leukemia cells. We produced Ara-C-resistant cells from the CCRF-CEM (acute lymphoblastic leukemia) cell line an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bf801a5fe38a3042c1163af32bfca7
https://pubmed.ncbi.nlm.nih.gov/15632314
https://pubmed.ncbi.nlm.nih.gov/15632314
Publikováno v:
Blood Cancer Journal
A single somatic mutation, V617F, in Janus kinase 2 (JAK2) is one of the causes of myeloproliferative neoplasms (MPNs), including primary myelofibrosis, and the JAK2V617F mutant kinase is a therapeutic target in MPN. However, inhibition of wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb76d61017b408bc5c9eceff6de90d24
http://europepmc.org/articles/PMC3913942
http://europepmc.org/articles/PMC3913942
Publikováno v:
Biochemistry. 40(37)
Escherichia coli ferredoxin (Fdx) is an adrenodoxin-type [2Fe-2S] ferredoxin. Recent genetic analyses show that it has an essential role in the maturation of various iron-sulfur (Fe-S) proteins. Fdx probably functions as a component of the complex ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b54bcc0817cde5e715da012966d12c1
https://pubmed.ncbi.nlm.nih.gov/11551196
https://pubmed.ncbi.nlm.nih.gov/11551196
Autor:
Kotaro Shide, Jun Miyake, Tatsuya Horio, Haruna Naito, Kazuya Shimoda, Tomoko Niwa, Yohei Nakaya
Publikováno v:
Blood. 122:3847-3847
A single somatic mutation, V617F, in Janus kinase 2 (JAK2) is one of the causes of myeloproliferative neoplasms (MPN), including primary myelofibrosis, and the mutant kinase JAK2V617F is a therapeutic target in MPN. However, inhibition of wild-type J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22fdbf54d23670f08e103e1dc736952
https://doi.org/10.1182/blood.v122.21.3847.3847
https://doi.org/10.1182/blood.v122.21.3847.3847
Autor:
Kazuya Kuramoto, Junko Homan, Hiroshi Shibayama, Seishi Sugahara, Takashi Kotera, Kazuya Shimoda, Koichi Hori, Tomoko Niwa, Tatsuya Horio, Haruna Naito, Kotaro Shide, Yohei Nakaya
Publikováno v:
Blood Cancer Journal
Aberrant activation of Janus kinase 2 (JAK2) caused by somatic mutation of JAK2 (JAK2V617F) or the thrombopoietin receptor (MPLW515L) plays an essential role in the pathogenesis of myeloproliferative neoplasms (MPNs), suggesting that inhibition of ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475450bdbd26d44344fe6f6199af4397
https://doi.org/10.1038/bcj.2011.29
https://doi.org/10.1038/bcj.2011.29