Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Tatsuya Dokoshi"'
Autor:
Tatsuya Dokoshi, Yang Chen, Kellen J. Cavagnero, Gibraan Rahman, Daniel Hakim, Samantha Brinton, Hana Schwarz, Elizabeth A. Brown, Alan O’Neill, Yoshiyuki Nakamura, Fengwu Li, Nita H. Salzman, Rob Knight, Richard L. Gallo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The composition of the microbial community in the intestine may influence the functions of distant organs such as the brain, lung, and skin. These microbes can promote disease or have beneficial functions, leading to the hypothesis that micr
Externí odkaz:
https://doaj.org/article/4267502e50f84cdea19b99fb89c67bd3
Autor:
Teruaki Nakatsuji, Samantha L. Brinton, Kellen J. Cavagnero, Alan M. O’Neill, Yang Chen, Tatsuya Dokoshi, Anna M. Butcher, Olive C. Osuoji, Faiza Shafiq, Josh L. Espinoza, Christopher L. Dupont, Tissa R. Hata, Richard L. Gallo
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112494- (2023)
Summary: During inflammation, the skin deploys antimicrobial peptides (AMPs) yet during allergic inflammation it becomes more susceptible to Staphylococcus aureus. To understand this contradiction, single-cell sequencing of Il4ra−/− mice combined
Externí odkaz:
https://doaj.org/article/c523e643008445ddb28c15744b1f3886
Autor:
Tatsuya Dokoshi, Ling-juan Zhang, Fengwu Li, Teruaki Nakatsuji, Anna Butcher, Hiroyuki Yoshida, Masayuki Shimoda, Yasunori Okada, Richard L. Gallo
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 61-68.e4 (2020)
Summary: Staphylococcus aureus is a major human bacterial pathogen responsible for deep tissue skin infections. Recent observations have suggested that rapid, localized digestion of hyaluronic acid in the extracellular matrix (ECM) of the dermis may
Externí odkaz:
https://doaj.org/article/b922211d152b4f5bace3d29f889d40fd
Autor:
Yue Zhang, Bharathi, Vanthana, Tatsuya Dokoshi, de Anda, Jaime, Ursery, Lauryn Tumey, Kulkarni, Nikhil N., Yoshiyuki Nakamura, Chen, Jonathan, Luo, Elizabeth W. C., Lamei Wang, Hua Xu, Coady, Alison, Zurich, Raymond, Lee, Michelle W., Tsutomu Matsui, HongKyu Lee, Chan, Liana C., Schepmoes, Athena A., Lipton, Mary S., Rui Zhao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/6/2024, Vol. 121 Issue 6, p1-12, 22p
Autor:
Alan M. O’Neill, Marc C. Liggins, Jason S. Seidman, Tran H. Do, Fengwu Li, Kellen J. Cavagnero, Tatsuya Dokoshi, Joyce Y. Cheng, Faiza Shafiq, Tissa R. Hata, Johann E. Gudjonsson, Robert L. Modlin, Richard L. Gallo
Publikováno v:
Sci Transl Med
Science translational medicine, vol 14, iss 632
Science translational medicine, vol 14, iss 632
Innate immune defense against deep tissue infection by Staphylococcus aureus is orchestrated by fibroblasts that become antimicrobial when triggered to differentiate into adipocytes. However, the role of this process in noninfectious human diseases i
Autor:
Takuya Iwama, Katsuyoshi Ando, Hiroaki Konishi, Tatsuya Dokoshi, Shin Kashima, Aki Sakatani, Hiroki Tanaka, Mikihiro Fujiya, Nobuhiro Ueno, Toshikatsu Okumura, Kentaro Moriichi
Publikováno v:
Cell Death and Disease, Vol 11, Iss 4, Pp 1-16 (2020)
Cell Death & Disease
Cell Death & Disease
RNA regulation mediating RNA-binding proteins (RBPs) have been shown to be related to the maintenance of homeostasis as well as cancer progression. However, the tumor-associated functions as well as the detailed mechanisms underlying the anti-tumor e
Autor:
Marc C. Liggins, Nita H. Salzman, Richard L. Gallo, Jocelyn G. Olvera, John T. Chang, Bryn C. Taylor, Jason S Seidman, Tatsuya Dokoshi, Kellen J. Cavagnero, Rob Knight, Fengwu Li
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 131, iss 21
The Journal of clinical investigation, vol 131, iss 21
Inflammatory disorders of the skin are frequently associated with inflammatory bowel diseases (IBDs). To explore mechanisms by which these organs communicate, we performed single-cell RNA-Seq analysis on fibroblasts from humans and mice with IBD. Thi
Autor:
Richard L. Gallo, Tatsuya Dokoshi, Alan M. O’Neill, Elizabeth Wei Chia Luo, Nikhil Nitin Kulkarni, Gerard C. L. Wong
Publikováno v:
The Journal of Biological Chemistry
The Journal of biological chemistry, vol 297, iss 1
The Journal of biological chemistry, vol 297, iss 1
Cathelicidins such as the human 37-amino acid peptide (LL-37) are peptides that not only potently kill microbes but also trigger inflammation by enabling immune recognition of endogenous nucleic acids. Here, a detailed structure-function analysis of
Autor:
Richard L. Gallo, Marc C. Liggins, Tatsuya Dokoshi, George L. Sen, Teruaki Nakatsuji, Yu Sawada, Nikhil Nitin Kulkarni
Publikováno v:
Science immunology, vol 6, iss 59
Sci Immunol
Sci Immunol
The skin typically tolerates exposure to various microbes and chemicals in the environment. Here, we investigated how the epidermis maintains this innate immune tolerance to stimuli that are recognized by Toll-like receptors (TLRs). Loss of tolerance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d149e8175df57a15b8d0016b8ea81ccc
https://escholarship.org/uc/item/5db3p8h5
https://escholarship.org/uc/item/5db3p8h5
Publikováno v:
J Immunol
A subset of dermal fibroblasts undergo rapid differentiation into adipocytes in response to infection and acutely produce the cathelicidin antimicrobial peptide gene Camp. Vitamin A and other retinoids inhibit adipogenesis yet can show benefit to ski