Zobrazeno 1 - 10
of 566
pro vyhledávání: '"Tatsuya, Higashi"'
Autor:
Mitsuhiro Shinada, Masashi Takahashi, Chika Igarashi, Hiroki Matsumoto, Fukiko Hihara, Tomoko Tachibana, Masakazu Oikawa, Hisashi Suzuki, Ming-Rong Zhang, Tatsuya Higashi, Hiroaki Kurihara, Yukie Yoshii, Yoshihiro Doi
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 820 (2024)
Copper (Cu) is a critical element for cancer cell proliferation and considerably accumulates in the nucleus. 64Cu2+ is an anticancer radiopharmaceutical that targets the copper requirement of cancer cells. However, intravenously injected 64Cu2+ ions
Externí odkaz:
https://doaj.org/article/2ec27f9bcaab4665b5ade683d11324ac
Autor:
Koichiro Sumi, Kana Yamazaki, Ryuichi Nishii, Misato Sakuda, Kentaro Nakamura, Kinya Ashida, Kentaro Tamura, Tatsuya Higashi
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0305620 (2024)
Although the standard method to evaluate skeletal muscle protein synthesis (MPS) is muscle biopsy, the method is invasive and problematic for multisite use. We conducted a small pilot study in volunteers to investigate changes in MPS according to ske
Externí odkaz:
https://doaj.org/article/8e855bee0a21442c947d221c37795119
Publikováno v:
Cancer Reports, Vol 6, Iss 12, Pp n/a-n/a (2023)
Abstract Background Osteoblastic skeletal metastasis is frequently observed in prostate cancer. An effective therapy has not been developed due to the unclear molecular mechanism. The Wnt family is involved in various biological phenomena including b
Externí odkaz:
https://doaj.org/article/cc4525e0e13946b1a33f735ae22e8d39
Autor:
Tomoko Tachibana, Tomoko Gowa Oyama, Yukie Yoshii, Fukiko Hihara, Chika Igarashi, Mitsuhiro Shinada, Hiroki Matsumoto, Tatsuya Higashi, Toshihiko Kishimoto, Mitsumasa Taguchi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17234 (2023)
Managing metastasis at the early stage and detecting and treating submillimeter tumors at early metastasis are crucial for improving cancer prognosis. Angiogenesis is a critical target for developing drugs to detect and inhibit submillimeter tumor gr
Externí odkaz:
https://doaj.org/article/11c3e5dfcac2430f9f99d0cd36bfbfbb
Autor:
Mitsuhiro Shinada, Hisashi Suzuki, Masayuki Hanyu, Chika Igarashi, Hiroki Matsumoto, Masashi Takahashi, Fukiko Hihara, Tomoko Tachibana, Chizuru Sogawa, Ming-Rong Zhang, Tatsuya Higashi, Hidemitsu Sato, Hiroaki Kurihara, Yukie Yoshii, Yoshihiro Doi
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 10 (2023)
[64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM) is a radioactive hypoxia-targeting therapeutic agent being investigated in clinical trials for malignant brain tumors. For the quality management of [64Cu]Cu-ATSM, understanding trace
Externí odkaz:
https://doaj.org/article/c8bb42d4b1ee4732af26836bf81048f1
Autor:
Yukie Yoshii, Hiroki Matsumoto, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Mitsuhiro Shinada, Atsuo Waki, Sei Yoshida, Kenichiro Naito, Kimiteru Ito, Tatsuya Higashi, Hiroaki Kurihara, Makoto Ueno
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1341 (2023)
Understanding the physicochemical properties of antibody–drug conjugates is critical to assess their quality at manufacturing and monitor them during subsequent storage. For radiometal–antibody complexes, it is important to control the properties
Externí odkaz:
https://doaj.org/article/7b2fb5433caf4e8faa8f63f71d8cb5a2
Autor:
Tetsuya Sakashita, Shojiro Matsumoto, Shigeki Watanabe, Hirofumi Hanaoka, Yasuhiro Ohshima, Yoko Ikoma, Naoyuki Ukon, Ichiro Sasaki, Tatsuya Higashi, Tetsuya Higuchi, Yoshito Tsushima, Noriko S. Ishioka
Publikováno v:
EJNMMI Physics, Vol 8, Iss 1, Pp 1-15 (2021)
Abstract Background We recently reported a new absorbed dose conversion method, RAP (RAtio of Pharmacokinetics), for 211At-meta-astatobenzylguanidine (211At-MABG) using a single biodistribution measurement, the percent injected dose/g. However, there
Externí odkaz:
https://doaj.org/article/8fb5e853cf504cbdb67b00c25c6997b4
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102397- (2022)
Externí odkaz:
https://doaj.org/article/1f036ad967244d10b78c53f19daebc58
Autor:
Aya Sugyo, Atsushi B Tsuji, Hitomi Sudo, Yoshinori Narita, Kenji Taniguchi, Takayuki Nemoto, Fumihisa Isomura, Norihiro Awaya, Mika Kamata-Sakurai, Tatsuya Higashi
Publikováno v:
Translational Oncology, Vol 23, Iss , Pp 101481- (2022)
CD137 is an attractive target for cancer immunotherapy, but its expression in normal tissues induces some adverse effects in patients receiving CD137-targeted therapy. To overcome this issue, we developed a switch antibody, STA551, that binds to CD13
Externí odkaz:
https://doaj.org/article/b5115d709b7a4524881493bb33ed8f18
Autor:
Rumiana Bakalova, Dessislava Lazarova, Akira Sumiyoshi, Sayaka Shibata, Zhivko Zhelev, Biliana Nikolova, Severina Semkova, Tatyana Vlaykova, Ichio Aoki, Tatsuya Higashi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8435 (2023)
Our study proposes a pharmacological strategy to target cancerous mitochondria via redox-cycling “mitocans” such as quinone/ascorbate (Q/A) redox-pairs, which makes cancer cells fragile and sensitive without adverse effects on normal cells and ti
Externí odkaz:
https://doaj.org/article/3e9d8696110a45c9bdab1ccb30c31713